Sepsis-induced cardiac dysfunction: mitochondria and energy metabolism DOI Creative Commons

Xueting Yu,

Jie Gao, Chunxiang Zhang

et al.

Intensive Care Medicine Experimental, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 18, 2025

Abstract Sepsis is a life-threatening multi-organ dysfunction syndrome caused by dysregulated host response to infection, posing significant global healthcare challenge. Sepsis-induced myocardial (SIMD) common complication of sepsis, significantly increasing mortality due its high energy demands and low compensatory reserves. The substantial mitochondrial damage rather than cell apoptosis in SIMD suggests disrupted cardiac metabolism as crucial pathophysiological mechanism. Therefore, we systematically reviewed the mechanisms underlying SIMD, including alterations substrates, excitation–contraction coupling processes, dysfunction, autophagy biogenesis, summarizing potential therapeutic targets within them.

Language: Английский

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation DOI Creative Commons
Dandan Liu,

Hewei Qin,

Yang Gao

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107258 - 107258

Published: June 21, 2024

Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.

Language: Английский

Citations

20
Recommendations for mitochondria transfer and transplantation nomenclature and characterization DOI Creative Commons
Jonathan R. Brestoff, Keshav K. Singh, Katia Aquilano

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

3
Dl-3-n-butylphthalide attenuates cerebral ischemia/reperfusion injury in mice through AMPK-mediated mitochondrial fusion DOI Creative Commons
Ting Zhu,

Shanshan Dong,

Na Qin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Introduction: NBP is a compound isolated from celery seeds, which was approved by the National Medical Products Administration in 2002 for clinical treatment of ischemic stroke. However, brain ischemia/reperfusion (I/R) injury, related research on mitochondrial dynamics and its mechanism action still need to be further studied. The aim this study assess cerebral pathology stroke vivo , with specific focus molecular mechanisms how promotes fusion. Methods: Male C57BL/6 mice were utilized subjected middle artery occlusion/reperfusion (MCAO/R). Pre-ischemia, administered through intraperitoneal (i.p.) injection 7 days. Results: Our findings demonstrated that effectively reduced infarct volume, improved neurological dysfunction, enhanced blood flow, promoted fusion MCAO/R. More importantly, pro-fusion effects found linked activation AMPK/Mfn1 pathway, function, partially eliminated inhibitors AMPK. Discussion: results revealed novel promoter protecting against AMPK-mediated Mfn1. These contribute understanding involved protection function following

Language: Английский

Citations

11
Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy DOI Creative Commons
Zdeněk Kejík, Jan Hajduch, Nikita Abramenko

et al.

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 13, 2024

Abstract Mitochondrial dysregulation plays a significant role in the carcinogenesis. On other hand, its destabilization strongly represses viability and metastatic potential of cancer cells. Photodynamic photothermal therapies (PDT PTT) target mitochondria effectively, providing innovative non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show enhancing PDT PTT. The limitations cyanine dyes for PTT are discussed, along their applications combination therapies, theranostic techniques, optimal delivery systems. Additionally, novel approaches sonodynamic therapy using photoactive presented, highlighting advances treatment.

Language: Английский

Citations

8
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome DOI
Ritsuko Nakai, Stella Varnum, Rachael L. Field

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

8
Mitochondrial quality control: Biochemical mechanism of cardiovascular disease DOI Creative Commons

Francesca Inferrera,

Ylenia Marino,

Tiziana Genovese

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119906 - 119906

Published: Jan. 19, 2025

Language: Английский

Citations

1
Nanoenzyme-Anchored Mitofactories Boost Mitochondrial Transplantation to Restore Locomotor Function after Paralysis Following Spinal Cord Injury DOI

Runxiu Wei,

Yongjun Chen, Qiang Yang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Mitochondrial transplantation is a significant therapeutic approach for addressing mitochondrial dysfunction in patients with spinal cord injury (SCI), yet it limited by rapid deactivation and low transfer efficiency. Here, high-quality mitochondria microfactories (HQ-Mitofactories) were constructed anchoring Prussian blue nanoenzymes onto mesenchymal stem cells effective to treat paralysis from SCI. Notably, the results demonstrated that HQ-Mitofactories could continuously produce vitality-boosting highly interconnected elongated network structures under oxidative stress scavenging excessive ROS. Furthermore, enabled efficient of injured neurons primarily via gap junctions, resulting restoration homeostasis thereby suppressing intracellular ROS burst facilitating neuronal repair. After i.v. administration, migrated cords SCI mice subsequently promoted regeneration remyelination. Consequently, HQ-Mitofactory-treated successfully recovered locomotor function within 4 weeks, 40% fully restoring walking after hindlimb paralysis. Conversely, untreated exhibited completely abolished movements. In light real-time generation even enabling targeted transfer, have promising potential context reduce SCI-related paralysis, more broadly impact field neuroregenerative medicine.

Language: Английский

Citations

1
Mitochondria Express Functional Signaling Ligand-Binding Receptors that Regulate their Biological Responses – the Novel Role of Mitochondria as Stress-Response Sentinels DOI Creative Commons
Katarzyna Brzeźniakiewicz‐Janus, Justyna Jarczak,

Adrian Konopko

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Evidence accumulated mitochondria, as the "powerplants of cell," express several functional receptors for external ligands that modify their function and regulate cell biology. This review sheds new light on role these organelles in sensing stimuli to facilitate energy production cellular needs. is possible because mitochondria some membranes are responsible autonomous responses. not surprising given widely accepted hypothesis intracellular originated from prokaryotic ancestors fused with eukaryotic cells during early evolution. It has been reported estrogen, androgen, glucocorticoid, 5-hydroxytryptamine, melatonin, cannabinoid receptors. What intriguing recent evidence showing could also be directly regulated by active mediators complement (complosome) intrinsic purinergic signaling. Accordingly, they cleavage fragments (C5a C3a) well adenosine triphosphate (ATP), which, besides its crucial transferring cells, an important signaling molecule interacting P2X7 receptor expressed only surface but membrane. Based this, complosome emerge cooperating regulators reactive oxygen species (ROS) release activators pattern recognition Nlrp3 inflammasome. activation within beneficial "hormetic zone response" regulates metabolism, proliferation, migration, adaptation surrounding challenges microenvironment a favorable way.

Language: Английский

Citations

1
Positively Charged Nanoplastics Destruct the Structure of the PCK1 Enzyme, Promote the Aerobic Gycolysis Pathway, and Induce Hepatic Tumor Risks DOI
Yudi Wang,

Jiaoyue Cong,

Xiaoyan Kong

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

The production and weathering processes of nanoparticles (NPs) introduce charged functional groups on their surface. Previous studies have found that the surface charge properties NPs play a critical role in toxic effects mechanisms are generally attributed to different accumulations transmembrane potentials. Currently, we still lack sufficient knowledge about effects, owing unique structures these polymers. In this study, positively (PS-NH2, 50 nm) at 0.05-0.5 μg mL-1 promoted proliferation hepatic tumors oncogenic KrasG12V zebrafish larvae they also increased viability human hepatocellular carcinoma cells, whereas negatively (PS-COOH, did not. We present evidence indicating potential carcinogenicity PS-NH2 is related special polymer-molecular interactions caused by its positive charge. affinity PS-COOH chains for peptides typically enhances enzyme stability upregulates expression. However, strongly competes with hydrogen bonds first rate-limiting PCK1 gluconeogenesis, thus downregulating expression promoting aerobic glycolysis pathway, which most tumor cells prefer. This study indicates positive-charge modified environment may bring additional carcinogenic risks.

Language: Английский

Citations

1
Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases DOI Creative Commons
Roberto Iorio, Sabrina Petricca, Vincenzo Mattei

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 24, 2024

Abstract Intercellular mitochondrial transfer (MT) is a newly discovered form of cell-to-cell signalling involving the active incorporation healthy mitochondria into stressed/injured recipient cells, contributing to restoration bioenergetic profile and cell viability, reduction inflammatory processes normalisation calcium dynamics. Recent evidence has shown that MT can occur through multiple cellular structures mechanisms: tunneling nanotubes (TNTs), via gap junctions (GJs), mediated by extracellular vesicles (EVs) other mechanisms (cell fusion, extrusion migrasome-mediated mitocytosis) in different contexts, such as under physiological (tissue homeostasis stemness maintenance) pathological conditions (hypoxia, inflammation cancer). As Mesenchimal Stromal/ Stem Cells (MSC)-mediated emerged critical regulatory restorative mechanism for tissue regeneration damage repair recent years, its potential stem therapy received increasing attention. In particular, therapeutic role MSCs been reported several articles, suggesting enhance after injury membrane vesicle release. For these reasons, this review, we will discuss MSCs-mediated effects on diseases neuronal, ischaemic, vascular pulmonary diseases. Therefore, understanding molecular demonstrating efficacy could be an important milestone lays foundation future clinical trials.

Language: Английский

Citations

8