bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: May 15, 2022
Neuronal
population
activity
in
sensory
cortices
is
the
substrate
for
perceptual
decisions.
Yet,
we
still
do
not
understand
how
neuronal
information
content
relates
to
behavioral
reports.
To
reconcile
neurometric
and
psychometric
performance,
recorded
of
V1
neurons
mice
performing
a
Go/NoGo
orientation
discrimination
task.
We
found
that,
around
threshold,
does
represent
stimuli
as
canonically
expected.
Instead,
it
forms
categorical
representations
characterized
by
relocation
at
task-relevant
domains
representational
space.
The
relative
those
discrete
accurately
predicted
probabilities
animals’
Our
results
thus
suggest
that
integration
discretized
feature
from
explains
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Nov. 22, 2024
This
study
delves
into
the
claustrum's
role
in
modulating
spontaneous
and
sensory-evoked
network
activity
across
cortical
regions.
Using
mesoscale
calcium
imaging
Gi
Gq
DREADDs
anesthetized
mice,
we
show
that
decreasing
claustral
enhances
prefrontal
activity,
while
activation
reduces
activity.
claustrum
modulation
also
caused
changes
to
brain's
large-scale
functional
networks,
emphasizing
ability
influence
long-range
connectivity
cortex.
Claustrum
inhibition
increased
local
coupling
between
frontal
cortex
areas,
but
reduced
correlation
anterior
medial
regions
lateral/posterior
regions,
enhancing
responses
visual
These
findings
indicate
can
participate
orchestrating
neural
communication
through
of
insights
deepen
our
understanding
impact
on
connectivity,
dynamics,
sensory
processing,
positioning
as
a
key
node
dynamics.
Chemogenetic
claustro-cortical
neurons
alters
measured
by
fluorescence
mice.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 11, 2023
Abstract
In
recent
years,
there
has
been
a
growing
interest
in
understanding
the
function
of
claustrum.
The
claustrum
is
thin,
long,
subcortical
structure
with
dense
connections
to
cortex.
Despite
these
extensive
connections,
manner
which
influences
broader
cortical
activity
remains
unclear.
We
used
mesoscale
calcium
fluorescence
imaging
examine
resting
state
(1-5Hz)
and
sensory-evoked
responses
lightly
anesthetized
mice,
before
after
bi-directional
chemogenetic
modulation
claustrum-prefrontal
neurons.
Claustrum
inhibition
resulted
increased
anterior-medial
areas,
whereas
excitation
decreased
regions.
also
led
an
local
coupling
between
areas
frontal
cortex,
correlation
anterior
medial
regions-of-interest
(ROIs)
lateral
posterior
ROIs,
sensory
evoked
response
visual
These
results
are
consistent
finding
that
large
feed-forward
inhibitory
effect
on
PFC,
concept
specific
claustrocortical
pathways
may
modulate
recruit
synchronize
topographically
distinct
modules.
Together
show
neural
modulates
excitability
prefrontal
networks,
suggesting
potential
target
for
prefrontal-dependent
behaviors
such
as
learning,
attention,
stress
regulation.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 17, 2023
Prediction
mismatch
responses
in
cortex
seem
to
signal
the
difference
between
an
internal
model
of
animal
and
sensory
observations.
Often
these
are
interpreted
as
evidence
for
existence
error
neurons,
which
guide
inference
models
hierarchical
predictive
coding.
Here
we
show
that
prediction
also
arise
naturally
a
spiking
encoding
signals,
where
spikes
predict
future
signal.
In
this
model,
representation
has
be
corrected
when
mispredicted
stimulus
appears,
requires
additional
neural
activity.
This
adaptive
correction
could
explain
why
response
latency
can
vary
with
detection
difficulty,
network
gathers
before
committing
correction.
thus
might
not
reflect
computation
errors
per
se,
but
rather
reorganization
code
new
information
is
incorporated.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: May 15, 2022
Neuronal
population
activity
in
sensory
cortices
is
the
substrate
for
perceptual
decisions.
Yet,
we
still
do
not
understand
how
neuronal
information
content
relates
to
behavioral
reports.
To
reconcile
neurometric
and
psychometric
performance,
recorded
of
V1
neurons
mice
performing
a
Go/NoGo
orientation
discrimination
task.
We
found
that,
around
threshold,
does
represent
stimuli
as
canonically
expected.
Instead,
it
forms
categorical
representations
characterized
by
relocation
at
task-relevant
domains
representational
space.
The
relative
those
discrete
accurately
predicted
probabilities
animals’
Our
results
thus
suggest
that
integration
discretized
feature
from
explains
