The neural link between stimulus duration and spatial location in the human visual hierarchy DOI Creative Commons
Valeria Centanino, Gianfranco Fortunato, Domenica Bueti

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 27, 2024

Integrating spatial and temporal information is essential for our sensory experience. While psychophysical evidence suggests dependencies in duration perception, few studies have directly tested the neural link between processing. Using ultra-high-field functional MRI neuronal-based modeling, we investigated how where processing representation of a visual stimulus linked to that its location. Our results show transition coding: from monotonic spatially-dependent early cortex unimodal spatially-invariant frontal cortex. Along dorsal stream, particularly intraparietal sulcus (IPS), neuronal populations common selective responses both information. In IPS, topographic organizations are also linked, although maps smaller, less clustered, more variable across participants. These findings help identify mechanisms underlying human perception characterize time space processing, highlighting importance their interactions shaping brain responses. Common organizational principles not fully understood. This study shows coding brief events transforms along cortical hierarchy, interact through representations.

Language: Английский

Rats synchronize predictively to metronomes DOI Creative Commons
Vani G. Rajendran,

Yehonadav Tsdaka,

Tung Yee Keung

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111053 - 111053

Published: Sept. 27, 2024

Language: Английский

Citations

2
Multi-Stable Bimodal Perceptual Coding within the Ventral Premotor Cortex DOI Creative Commons

Bernardo Andrade-Ortega,

Héctor Luis Díaz,

Lucas Bayones

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Neurons of the primate ventral premotor cortex (VPC) respond to tactile or acoustic stimuli. But how VPC neurons process and integrate information from these two sensory modalities during perception remains unknown. To investigate this, we recorded activity in trained monkeys performing a bimodal detection task (BDT). In BDT, subjects reported presence absence an stimulus. Initial single-cell analyses revealed diverse range responses BDT: purely tactile, acoustic, others that exhibited sustained decision maintenance delay—between stimulus offset motor report. further explore VPC’s role applied dimensionality reduction techniques uncover low-dimensional latent dynamics neuronal population conducted parallel on recurrent neural network (RNN) model same task. Neural trajectories associated with diverged strongly those related responses. Conversely, stimulus-absent trials remained at rest. During delay, demonstrated pronounced rotational dynamic toward subspace orthogonal response space, supporting memory stable equilibria. This suggests can sustain distinct states corresponding three potential outcomes. Using modeling, propose universal dynamical mechanism underlying transition mnemonic processing, consistent our experimental computational observations. These findings show contains capable coding its competing maintain decisions throughout delay period, regardless modality.

Language: Английский

Citations

1
Probing beat perception with event-related potentials (ERPs) in human adults, newborns, and non-human primates DOI Open Access
Fleur L. Bouwer, Gábor P. Háden, Henkjan Honing

et al.

Published: Nov. 28, 2023

The aim of this chapter is to give an overview how the perception rhythmic temporal regularity such as a regular beat in music can be studied human adults, newborns, and non-human primates using event-related brain potentials (ERPs). First, we discuss different aspects structure general, musical rhythm particular, possible mechanisms underlying (e.g., beat) rhythm. Additionally, highlight importance dissociating from other types rhythm, predictable sequences intervals, ordinal structure, grouping. In second section chapter, start with discussion auditory ERPs elicited by infrequent frequent sounds: ERP responses violations, mismatch negativity (MMN), N2b, P3, well early sensory sounds, P1 N1, have been shown instrumental probing perception. Subsequently, probed comparing sounds irregular sequences, metrical positions on off or strong weak beats. Finally, will previous research that has used aforementioned paradigms study primates. doing so, consider pitfalls prospects technique, future perspectives.

Language: Английский

Citations

1
Stable sequential dynamics in prefrontal cortex represents subjective estimation of time DOI Creative Commons
Yiting Li,

Wenqu Yin,

Xin Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Abstract Time estimation is an essential prerequisite underlying various cognitive functions. Previous studies identified “sequential firing” and “activity ramps” as the primary neuron activity patterns in medial frontal cortex (mPFC) that could convey information regarding time. However, relationship between these timing behavior has not been fully understood. In this study, we utilized vivo calcium imaging of mPFC rats performing a task. We observed cells showed selective activation at trial start, end, or during interval. By aligning long-term time-lapse datasets, discovered sequential time coding were stable over weeks, while for start end constant dynamism. Furthermore, with novel design allowed animal to determine individual interval, able demonstrate real-time adjustment sequence procession speed closely tracked trial-to-trial interval variations. And errors rats’ can be primarily attributed premature ending sequence. Together, our data suggest maybe neural substrate thatrepresentstime under physiological conditions.Furthermore, results imply existence unique cell type participates time-related sequences. Future characterization provide important insights mechanism related

Language: Английский

Citations

0
The link between space and time along the human cortical hierarchy DOI Creative Commons
Valeria Centanino, Gianfranco Fortunato, Domenica Bueti

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Abstract In humans, very few studies have directly tested the link between neural coding of time and space. Here we combined ultra-high field functional magnetic resonance imaging with neuronal-based modeling to investigate how where processing representation a visual stimulus duration is linked that its spatial location. Results show transition in response duration: from monotonic spatially-dependent early cortex, unimodal spatially-invariant frontal cortex. This begins extrastriate areas V3AB, it fully displays intraparietal sulcus (IPS), both responses are present neuronal populations selective either space, or both. IPS, space topographies specific relationship, although along cortical hierarchy maps compared ones smaller size, less clustered more variable across participants. These results help identify mechanisms through which humans perceive object location precisely characterize processing, highlighting importance space-time interactions shaping brain responses.

Language: Английский

Citations

0
Sequential and dynamic coding of water-sucrose categorization in rat gustatory cortices DOI Creative Commons
Germán Mendoza, Esmeralda Fonseca, Hugo Merchant

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Summary The gustatory system enables our conscious perception of sweetness, allowing us to distinguish sweet solutions from water. However, the neural mechanisms underlying this categorization process in rats remain poorly understood. We addressed question by designing a novel sucrose task which classified varying concentrations against found that anterior insular cortex (aIC) and orbitofrontal (OFC), activity primarily encoded categorical distinction between water, rather than specific concentrations. Notably, aIC neurons faster OFC neurons. Conversely, slightly preceded encoding choice information, although both cortices maintained parallel rat’s choices. sensory decisions was dynamic sequential, forming sequence throughout trial. These findings reveal relies on coding sequences neuronal static, long-lasting (sustained) representations. This coding, supported single-cell population decoding principal component analyses, suggests brain continuously updates its representation as new information emerges. Additionally, rapidly reward outcomes. Our data supports notion employ sequential compute sensorimotor transformations, taste detection processing. Graphical Abstract

Language: Английский

Citations

0
A Recurrent Neural Network for Rhythmic Timing DOI Creative Commons
Klavdia Zemlianova, Amitabha Bose, John Rinzel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 26, 2024

Abstract Despite music’s omnipresence, the specific neural mechanisms responsible to perceive and anticipate temporal patterns in music are unknown. To study potential for keeping time rhythmic contexts, we train a biologically constrained RNN on seven different stimulus tempos (2 – 8Hz) synchronization continuation task, standard experimental paradigm. Our trained generates network oscillator that uses an input current (context parameter) control oscillation frequency replicates key features of dynamics observed recordings monkeys performing same task. We develop reduced three-variable rate model analyze its dynamic properties. By treating our understanding mathematical structure oscillations as predictive, confirm dynamical found also RNN. neurally plausible reveals E-I circuit with two distinct inhibitory sub-populations, which one is tightly synchronized excitatory units.

Language: Английский

Citations

0
Stable sequential dynamics in prefrontal cortex represents subjective estimation of time DOI Creative Commons
Yiting Li,

Wenqu Yin,

Xin Wang

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: May 28, 2024

Time estimation is an essential prerequisite underlying various cognitive functions. Previous studies identified ‘sequential firing’ and ‘activity ramps’ as the primary neuron activity patterns in medial frontal cortex (mPFC) that could convey information regarding time. However, relationship between these timing behavior has not been fully understood. In this study, we utilized vivo calcium imaging of mPFC rats performing a task. We observed cells showed selective activation at trial start, end, or during interval. By aligning long-term time-lapse datasets, discovered sequential time coding were stable over weeks, while for start end constant dynamism. Furthermore, with novel design allowed animal to determine individual interval, able demonstrate real-time adjustment sequence procession speed closely tracked trial-to-trial interval variations. And errors rats’ can be primarily attributed premature ending sequence. Together, our data suggest maybe neural substrate represents under physiological conditions. results imply existence unique cell type participates time-related sequences. Future characterization provide important insights mechanism related

Language: Английский

Citations

0
Dynamical mechanisms of how an RNN keeps a beat, uncovered with a low-dimensional reduced model DOI Creative Commons
Klavdia Zemlianova, Amitabha Bose, John Rinzel

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Abstract Despite music’s omnipresence, the specific neural mechanisms responsible to perceive and anticipate temporal patterns in music are unknown. To study potential for keeping time rhythmic contexts, we train a biologically constrained RNN on seven different stimulus tempos (2–8Hz) synchronization continuation task, standard experimental paradigm. Our trained generates network oscillator that uses an input current (context parameter) control oscillation frequency replicates key features of dynamics observed recordings monkeys performing same task. We develop reduced three-variable rate model analyze its dynamic properties. By treating our understanding mathematical structure oscillations as predictive, confirm dynamical found also RNN. neurally plausible reveals E-I circuit with two distinct inhibitory sub-populations, which one is tightly synchronized excitatory units.

Language: Английский

Citations

0
Astrocytes in Pain Perception: A Systems Neuroscience Approach DOI

Angélica Rivera-Villaseñor,

Frida Higinio-Rodríguez, Mónica López‐Hidalgo

et al.

Advances in neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 193 - 212

Published: Jan. 1, 2024

Language: Английский

Citations

0