A new function of offset response in the primate auditory cortex: marker of temporal integration DOI Creative Commons
Peirun Song, Haoxuan Xu, Hangting Ye

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 18, 2024

Offset responses are traditionally viewed as indicators of sound cessation. Here, we investigate offset to auditory click trains, examining how they modulated by inter-click intervals (ICIs) and train duration. Using extracellular recordings electrocorticography (ECoG) in non-human primates, alongside electroencephalography (EEG) humans, show that significantly influenced both ICI length, thereby establishing them markers temporal integration. We introduce the concept 'Neuronal Integrative Window' (NIW), defined span during which neurons integrate stimuli produce or modulate integration signal. Our data reveal on neuronal level, cortex (AC) exhibits a more expansive NIW than medial geniculate body (MGB), integrating over longer durations showing preference for larger ICIs. Furthermore, our results indicate could serve potential biomarkers neurological psychiatric conditions, highlighted their sensitivity pharmacological modulation with ketamine. This study advances understanding processing proposes novel approach assessing monitoring brain health.

Language: Английский

Predictive coding: a more cognitive process than we thought? DOI

Kaitlyn M Gabhart,

Y. Xiong, André M. Bastos

et al.

Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Top-down prediction signals from the medial prefrontal cortex govern auditory cortex prediction errors DOI Creative Commons
A. D. Hockley, Laura H Bohórquez, Manuel S. Malmierca

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115538 - 115538

Published: April 1, 2025

Under the predictive coding framework, brain generates a model of environment based on previous experiences. Incoming sensory information is compared to this model, such that if predictions do not match inputs, prediction error generated. Predictions are passed top-down, and errors emerge when bottom-up does predictions. Prediction occur sequentially in primary auditory cortex (A1) then medial prefrontal (mPFC). Here, we test hypothesis mPFC sends contribute generation errors. We used optogenetics block top-down signals from while recording neuronal A1 under classical "oddball" paradigm. Blocking reduces response rare sounds, it affect responses predictable or random sounds. Our results provide empirical evidence for enhance unpredicted stimuli.

Language: Английский

Citations

1
Protocol for behavioral and neural recording in macaques during a novelty detection task DOI Creative Commons

Xinyu Du,

Peirun Song, Yumei Gong

et al.

STAR Protocols, Journal Year: 2024, Volume and Issue: 5(3), P. 103252 - 103252

Published: Aug. 10, 2024

The neural mechanisms of novelty detection, especially in relation to behavior, are currently poorly understood. Here, we present a protocol for recording neuronal activity macaque auditory cortex during detection tasks. We describe steps behavioral training, surgical headpost implantation, MRI-based electrode targeting, and electrophysiological recording. These allow direct assessment the correlation between behavior activity. For complete details on use execution this protocol, please refer Gong et al.

Language: Английский

Citations

4
Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Reward Prediction and Cognitive Decision-Making DOI Open Access

Xinyu Du,

Haoxuan Xu, Peirun Song

et al.

Published: Jan. 7, 2025

The Inferior Colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved relaying information from brainstem to thalamus. However, this study uncovers multifaceted role of IC bridging processing, sensory prediction, and reward prediction. Through extracellular recordings monkeys engaged a sound duration-based deviation detection task, we observed “climbing effect” neuronal firing rates, indicative enhanced response over sequences linked prediction rather than anticipation. Moreover, our findings demonstrate errors within IC, highlighting its complex integration processing. Further analysis revealed direct correlation between activity behavioral choices, suggesting involvement decision-making processes. This research highlights more for understood, showcasing integral cognitive processing emphasizing importance integrated brain functions.

Language: Английский

Citations

0
Responses to oddball communication sequences in the bat frontal and auditory cortices DOI Creative Commons
Eugenia González‐Palomares, Johannes Wetekam, Manuel S. Malmierca

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Stimulus-specific adaptation (SSA) is a ubiquitous phenomenon in the animal kingdom across sensory modalities, but this type of neural response has rarely been studied using natural sounds auditory brain. Here, we leveraged well-documented acoustic repertoire bat species Carollia perspicillata to study brain communication sounds. We searched for SSA single neuron spiking activity measured two areas simultaneously: cortex and frontal field. The stimuli consisted distress syllables, form vocalization produced by bats under duress. Bat vocalizations signal different degrees urgency based on their amplitude modulation pattern, without large differences spectral structure. These make an ideal test case exploring limits deviance detection when considering naturalistic soundscapes with low stimulus contrast. results show limited evidence stimulus-specific sound sequences majority neurons studied. Many did prominent effect related context-dependent changes, caused that occurred most frequently within each oddball sequence. Context-dependent responses were strongest neurons. Decoding analysis showed existence populations both cortices, which could distinguish between deviants standards occurring same sequence, changes evoked spike counts. Taken together, our highlight diversity mechanisms complementing classical encoding do not differ markedly composition.

Language: Английский

Citations

0
The impact of sleep deprivation on cognitive function in healthy adults: insights from auditory P300 and reaction time analysis DOI Creative Commons
Zhongkai Ren, Xiang Mao,

Ziyue Zhang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 9, 2025

This study aims to explore the effects of sleep deprivation on cognitive function in healthy adults, using auditory P300 event-related potentials and subjective reaction time as key assessment metrics. High-density electroencephalography (EEG) oddball paradigm were utilized collect (ERPs) before after intervention, with a record time. Participants classified into acute group chronic based duration their night shift history. Following deprivation, significant prolongation latency was observed among 26 subjects (P < 0.05). Specifically, increased significantly by 83.69 ms In contrast, exhibited only minor increase 6.54 Furthermore, interaction effect between history condition identified [F (aXb) = 4.736, P 0.040, η p 2 0.165], suggesting that influence varies groups. Sleep induces impairment, experiencing more severe deficits. demonstrated milder but impairment.

Language: Английский

Citations

0
Miguel A. Merchán and the Cajalian Influence: Pioneering Auditory Neuroscience in Spain DOI Creative Commons
Enrique Saldaña, Fernando de Castro, Dolores E. López

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109323 - 109323

Published: June 1, 2025

Language: Английский

Citations

0
Beyond Auditory Relay: Dissecting the Inferior Colliculus's Role in Sensory Prediction, Cognitive Decision-Making, and Reward Prediction DOI Creative Commons
Xinyu Du, Haoxuan Xu, Peirun Song

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract The Inferior Colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved relaying information from brainstem to thalamus. However, this study uncovers multifaceted role of IC bridging processing, sensory prediction, and reward prediction. Through extracellular recordings monkeys engaged a sound duration-based deviation detection task, we observed “climbing effect” neuronal firing rates, indicative enhanced response over sequences linked prediction rather than anticipation. Moreover, our findings demonstrate errors within IC, highlighting its complex integration processing. Further analysis revealed direct correlation between activity behavioral choices, suggesting involvement decision-making processes. This research highlights more for understood, showcasing integral cognitive processing emphasizing importance integrated brain functions.

Language: Английский

Citations

0
Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Cognitive Decision-Making, and Reward Prediction DOI Open Access

Xinyu Du,

Haoxuan Xu, Peirun Song

et al.

Published: Sept. 6, 2024

The Inferior Colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved relaying information from brainstem to thalamus. However, this study uncovers multifaceted role of IC bridging processing, sensory prediction, and reward prediction. Through extracellular recordings monkeys engaged a sound duration-based novelty detection task, we observed "climbing effect" neuronal firing rates, indicative enhanced response over sequences linked prediction rather than anticipation. Further exploration revealed direct correlation between activity behavioral choices, suggesting its involvement decision-making processes. Additionally, our findings demonstrate errors within IC, highlighting complex integration processing. This research challenges conventional views showcasing integral cognitive processing emphasizing importance integrated brain functions.

Language: Английский

Citations

0
Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Cognitive Decision-Making, and Reward Prediction DOI Open Access

Xinyu Du,

Haoxuan Xu, Peirun Song

et al.

Published: Sept. 6, 2024

The inferior colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved relaying information from brainstem to thalamus. However, this study uncovers multifaceted role of IC bridging processing, sensory prediction, and reward prediction. Through extracellular recordings monkeys engaged a sound duration-based deviation detection task, we observed 'climbing effect' neuronal firing rates, indicative enhanced response over sequences linked prediction rather than anticipation. Moreover, our findings demonstrate errors within IC, highlighting its complex integration processing. Further analysis revealed direct correlation between activity behavioral choices, suggesting involvement decision-making processes. This research highlights more for understood, showcasing integral cognitive processing emphasizing importance integrated brain functions.

Language: Английский

Citations

0