bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 21, 2024
Emerging evidence suggests the microbiome critically influences onset and progression of neurodegenerative diseases; however, identity neuroprotective bacteria molecular mechanisms that respond within host remain largely unknown. We took advantage
Language: Английский
Microbiome, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 20, 2025
Alzheimer's disease (AD) is a prevalent neurodegenerative (ND). In recent years, multiple clinical and animal studies have shown that mitochondrial dysfunction may be involved in the pathogenesis of AD. addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism been considered to important factors affecting central nervous system (CNS) homeostasis. Among main mediators host-microbe interactions, volatile play crucial role. Nevertheless, influence pathways microorganisms their metabolites on remain uncertain. this study, we present distinctions blood fecal SCFA levels composition between healthy individuals those diagnosed with We found AD patients showed decrease abundance Akkermansia muciniphila propionic acid both blood. order further reveal effects mechanisms prevention, systematically explored administration model mice cultured hippocampal neuronal cells. Results oral propionate supplementation ameliorated cognitive impairment mice. Propionate downregulated fission protein (DRP1) via G-protein coupled receptor 41 (GPR41) enhanced PINK1/PARKIN-mediated mitophagy 43 (GPR43) pathophysiology which contribute maintaining homeostasis vivo vitro. Administered A. before onset improved cognition, division Taken together, our results demonstrate its metabolite protect against AD-like pathological events mouse models targeting homeostasis, making them promising therapeutic candidates for prevention treatment
Language: Английский
Citations
1
Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115212 - 115212
Published: Oct. 20, 2024
Language: Английский
Citations
5
Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(2)
Published: Feb. 8, 2025
Language: Английский
Citations
0
Journal of Contemporary Medical Practice, Journal Year: 2025, Volume and Issue: 7(3), P. 166 - 169
Published: March 28, 2025
Appendectomy, a common procedure in general surgery, has traditionally been regarded as safe treatment for acute appendicitis. In recent years, with the advancement of research on microbiota-gut-brain axis (MGBA), increasing attention given to potential impact appendectomy mental health, appendix plays crucial role intestinal immunity and microbiota regulation. This review seeks examine advancements relationship between disorders, providing new insights into clinical decision-making process
Language: Английский
Citations
0
Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16
Published: April 2, 2025
Schizophrenia (SCZ) is a severe mental disorder with complex etiology. Research shows propionate metabolism crucial for neurological function and health. This suggests abnormalities in may link to SCZ. Therefore, identifying biomarkers associated might be beneficial the diagnosis treatment of SCZ patients. datasets metabolism-related genes (PMRGs) from public databases were obtained. DE-PMRGs identified through differential correlation analysis PMRGs. Machine learning was used screen key validate expression levels, aiming identify potential biomarkers. Gene Set Enrichment Analysis (GSEA) immune infiltration performed on An upstream regulatory network constructed, drugs targeting these explored. Finally, real-time fluorescence quantitative PCR (qPCR) verify biomarker levels. A total 11 identified, machine technology employed further 5 genes. Among these, LY96 TMEM123 emerged as verification. diagnostic model developed, achieving an area under curve (AUC) greater than 0.7, which indicates strong performance. Additionally, nomograms based demonstrated promising predictive capabilities assessing risk To explore gene functions mechanisms at deeper level, competitive endogenous RNA (ceRNA) including 2 biomarkers, 72 microRNAs, 202 long non-coding RNAs. In addition, containing 104 transcription factors (TFs) also established investigate interacting Potential biomarker-targeted by exploring DrugBank database; notably, exhibited higher binding affinities four drugs, docking scores consistently below-5 kcal/mol. The qPCR results indicated that levels whole blood patients significantly those healthy control group, consistent GSE38484 GSE27383 datasets. study disease SCZ, specifically TMEM123. These findings offer novel perspectives management
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3673 - 3673
Published: April 13, 2025
To date, Leucobacter species have been identified from diverse sources with various ecological and functional roles. However, the genomic features pathogenic potential of antibiotic-resistant strains remain understudied. Here, we isolated sp. HNU-1 tropical Hainan Province, China, found it can induce diapause in Caenorhabditis elegans following ingestion, while exhibiting no significant effects on nematode’s lifespan, survival rate, locomotion, intestinal epithelial cells. This bacterium demonstrates resistance to multiple antibiotics, including kanamycin, streptomycin, sulfonamides, vancomycin. On LB medium, forms yellow, opaque colonies a smooth, moist surface, regular edges, convex center, surrounding halo, diameters ranging 2 3 mm. Furthermore, performed whole-genome sequencing using third-generation high-throughput technology. De novo assembly revealed genome size 3,375,033 bp, GC content 70.37%. A total 3270 genes, accounting for 88.98% genome, were annotated, along six CRISPR sequences other genetic elements. Genomic bioinformatic analyses further antibiotics-related genes. research provides theoretical foundation investigating environmental bacteria environments offers new insights into therapeutic strategies microbial infections host–microbe interactions.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3928 - 3928
Published: April 22, 2025
The role of the intestinal microbiota and its influence on neurodegenerative disorders has recently been extensively explored, especially in context Parkinson’s disease (PD). In particular, immunomodulation, impact inflammation, participation gut–brain axis are under ongoing investigations. Recent studies have revealed new data that could be important for exploring neurodegeneration mechanisms connected with gut microbiota, potentially leading to development methods treatment. this review, potential roles future disease-modifying therapies were discussed properties microbiota—including impacts metabolism short-chain fatty acids vitamins—were summarized, a particular focus atypical Parkinsonian syndromes. This review focused detailed description numerous through which influences processes. explored connections between evolution progression Finally, derived results regarding alterations syndromes comparison previously described PD was also included.
Language: Английский
Citations
0
Neurogenetics, Journal Year: 2024, Volume and Issue: 25(4), P. 307 - 336
Published: Sept. 13, 2024
Language: Английский
Citations
2
Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 23, 2024
Summary Alzheimer's disease (AD) is the most common neurodegenerative disorder and cause of dementia. Despite prevalence AD, there a lack effective modifying therapies. Recent evidence indicates that gut microbiome (GMB) may play role in AD through its regulation innate adaptive immunity. Gut microbes regulate physiology their production metabolites byproducts. Microbial be beneficial or detrimental to pathogenesis progression inflammatory diseases. A better understanding GMB‐derived lead development therapeutic strategies for AD. In this review, we summarize function bioactive byproducts roles models. We also call more focus on area gut–brain axis field order create therapies
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 21, 2024
Emerging evidence suggests the microbiome critically influences onset and progression of neurodegenerative diseases; however, identity neuroprotective bacteria molecular mechanisms that respond within host remain largely unknown. We took advantage
Language: Английский
Citations
0