Identification and functional characterization of grass carp TRPV1 in facilitating GCRV infection DOI

Zi-Yu Xie,

Yang Xu, Qiushi Zhang

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742484 - 742484

Published: March 1, 2025

Language: Английский

Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21 DOI Creative Commons

Shanna Leventhal,

Thomas C. Bisom, Dean Clift

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 25, 2024

Language: Английский

Citations

4
TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus DOI Creative Commons
Chen Li,

Ang Ma,

Yu Bai

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The cGAS-STING signaling pathway serves as a pivotal surveillance mechanism for cytosolic double-stranded DNA (dsDNA) detection in mammalian systems. While STING-mediated type I interferon production is crucial host defense, sustained activation of this contributes to autoimmune pathologies, including systemic lupus erythematosus (SLE). Maintaining immune homeostasis requires precise regulation STING activity prevent hyperactivation. Our study identifies TRIM21 novel positive regulator SLE pathogenesis. results demonstrate that overexpression stabilizes by suppressing autophagic degradation, whereas depletion accelerates clearance process. Mechanistically, catalyzes the K63-linked polyubiquitylation selective autophagy receptor p62/SQSTM1, disrupting its interaction with STING. This post-translational modification prevents sequestration into autophagosomes, thereby stabilizing adaptor protein and amplifying downstream responses. findings reveal previously unrecognized regulatory circuit which orchestrates cross-talk between ubiquitin control turnover. TRIM21-p62 axis represents potential therapeutic target attenuating pathological STING-dependent disorders. work advances our understanding demonstrating how E3 ligase-mediated modifications modulate cargo recognition pathways. identified provides new insights molecular interplay ubiquitylation degradation maintaining innate balance, offering perspectives developing targeted therapies against interferonopathies associated hyperactivity.

Language: Английский

Citations

0
The role of ion channels in the regulation of dendritic cell function DOI
Shibin Zhou, Lanlan Zhong, Yi-Lan Wu

et al.

Cell Calcium, Journal Year: 2025, Volume and Issue: 128, P. 103031 - 103031

Published: April 17, 2025

Language: Английский

Citations

0
Identification and functional characterization of grass carp TRPV1 in facilitating GCRV infection DOI

Zi-Yu Xie,

Yang Xu, Qiushi Zhang

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742484 - 742484

Published: March 1, 2025

Language: Английский

Citations

0