Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 6, 2024
The
canonical
basal
ganglia
model
predicts
that
the
substantia
nigra
pars
reticulata
(SNr)
and
globus
pallidus
externa
(GPe)
will
have
specific
effects
on
locomotion:
SNr
inhibiting
locomotion
GPe
enhancing
it.
In
this
manuscript,
we
use
in
vivo
optogenetics
to
show
a
projection-defined
neural
subpopulation
within
each
structure
exerts
non-canonical
locomotion.
These
subpopulations
are
defined
by
their
projection
pedunculopontine
nucleus
(PPN)
mediate
opposing
reward.
To
understand
how
these
structures
differentially
modulate
PPN,
ex
whole-cell
recording
with
comprehensively
dissect
connections
regionally-
molecularly-defined
populations
of
PPN
neurons.
inhibits
all
subtypes,
but
most
strongly
caudal
glutamatergic
selectively
GABAergic
neurons,
avoiding
both
cholinergic
rostral
cells.
This
circuit
characterization
reveals
pathways
for
valence.
Language: Английский
Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors
Published: Oct. 30, 2024
The
canonical
basal
ganglia
model
predicts
that
the
substantia
nigra
pars
reticulata
(SNr)
and
globus
pallidus
externa
(GPe)
will
have
specific
effects
on
locomotion:
SNr
inhibiting
locomotion
GPe
enhancing
it.
In
this
manuscript,
we
use
in
vivo
optogenetics
to
show
a
projection-defined
neural
subpopulation
within
each
structure
exerts
non-canonical
locomotion.
These
subpopulations
are
defined
by
their
projection
pedunculopontine
nucleus
(PPN)
mediate
opposing
reward.
To
understand
how
these
structures
differentially
modulate
PPN,
ex
whole-cell
recording
with
comprehensively
dissect
connections
regionally–
molecularly-defined
populations
of
PPN
neurons.
inhibits
all
subtypes,
but
most
strongly
caudal
glutamatergic
selectively
GABAergic
neurons,
avoiding
both
cholinergic
rostral
cells.
This
circuit
characterization
reveals
pathways
for
valence.
Language: Английский
Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors
Published: Oct. 30, 2024
The
canonical
basal
ganglia
model
predicts
that
the
substantia
nigra
pars
reticulata
(SNr)
and
globus
pallidus
externa
(GPe)
will
have
specific
effects
on
locomotion:
SNr
inhibiting
locomotion
GPe
enhancing
it.
In
this
manuscript,
we
use
in
vivo
optogenetics
to
show
a
projection-defined
neural
subpopulation
within
each
structure
exerts
non-canonical
locomotion.
These
subpopulations
are
defined
by
their
projection
pedunculopontine
nucleus
(PPN)
mediate
opposing
reward.
To
understand
how
these
structures
differentially
modulate
PPN,
ex
whole-cell
recording
with
comprehensively
dissect
connections
regionally–
molecularly-defined
populations
of
PPN
neurons.
inhibits
all
subtypes,
but
most
strongly
caudal
glutamatergic
selectively
GABAergic
neurons,
avoiding
both
cholinergic
rostral
cells.
This
circuit
characterization
reveals
pathways
for
valence.
Language: Английский
Olfactory Projections to Locomotor Control Centers in the Sea Lamprey
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9370 - 9370
Published: Aug. 29, 2024
Although
olfaction
is
well
known
to
guide
animal
behavior,
the
neural
circuits
underlying
motor
responses
elicited
by
olfactory
inputs
are
poorly
understood.
In
sea
lamprey,
anatomical
evidence
shows
that
project
posterior
tuberculum
(PT),
a
structure
containing
dopaminergic
(DA)
neurons
homologous
mammalian
ventral
tegmental
area
and
substantia
nigra
pars
compacta.
Olfactory
travel
directly
from
medial
bulb
(medOB)
or
indirectly
through
main
lateral
pallium
(LPal).
Here,
we
characterized
transmission
of
PT
in
Petromyzon
marinus.
Abundant
projections
medOB
were
observed
close
DA
PT.
Moreover,
electrophysiological
experiments
revealed
activated
both
LPal,
calcium
imaging
indicated
signal
then
relayed
mesencephalic
locomotor
region
initiate
locomotion.
semi-intact
preparations,
stimulation
LPal
induced
locomotion
was
tightly
associated
with
activity
active
throughout
spontaneously
occurring
bouts.
Altogether,
our
observations
suggest
convey
PT,
which
turn
activate
brainstem
command
system
elicit
Language: Английский