Regulation of Mitochondria-Derived Immune Activation by ‘Antiviral’ TRIM Proteins DOI Creative Commons
Seeun Oh, Michael A. Mandell

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1161 - 1161

Published: July 19, 2024

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the assembly and activation innate immune-signaling complexes. In response to viral infection, mitochondria can be triggered release immune-stimulatory molecules boost interferon production. These same released by damaged induce pathogenic, antiviral-like immune in absence infection. This review explores how members tripartite motif-containing (TRIM) protein family, which recognized their roles defense, regulate mitochondria-based activation. TRIMs essential components signal transduction pathways function directly acting restriction factors. carry out conceptually similar activities when controlling related mitochondria. First, they modulate activated mitochondrial molecules. Second, co-ordinate direct removal associated immune-activating factors through mitophagy. insights broaden scope TRIM actions immunity may implicate diseases with mitochondria-derived inflammation.

Language: Английский

Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases DOI Creative Commons
Fivos Borbolis, Christina Ploumi, Konstantinos Palikaras

et al.

npj Metabolic Health and Disease, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 3, 2025

Language: Английский

Citations

1
Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease DOI Creative Commons

Moeka Nakashima,

Naoko Suga,

Yuka Ikeda

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 207 - 207

Published: Feb. 9, 2024

Polycystic kidney disease (PKD) is the most common genetic form of chronic (CKD), and it involves development multiple cysts. Not enough medical breakthroughs have been made against PKD, a condition which features regional hypoxia activation hypoxia-inducible factor (HIF) pathway. The following pathology CKD can severely instigate damage and/or renal failure. Significant evidence verifies an imperative role for mitophagy in normal physiology PKD. Mitophagy serves as important component mitochondrial quality control by removing impaired/dysfunctional mitochondria from cell to warrant redox homeostasis sustain viability. Interestingly, treatment with peroxisome proliferator-activated receptor-α (PPAR-α) agonist could reduce PDK might improve function via modulation mitophagy, well gut microbiome. Suitable be favorable tactic prevention diseases such PKD CKD.

Language: Английский

Citations

6
Advances in mitophagy initiation mechanisms DOI Creative Commons
Catharina J. Küng, Michael Lazarou, Thanh Ngoc Nguyen

et al.

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 94, P. 102493 - 102493

Published: March 21, 2025

Language: Английский

Citations

0
Cyclophilin A Regulates Tripartite Motif 5 Alpha Restriction of HIV-1 DOI Open Access
Tingting Wang, Daniel Becker, Augustin Penda Twizerimana

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 495 - 495

Published: Jan. 9, 2025

The peptidyl-prolyl isomerase A (PPIA), also known as cyclophilin (CYPA), is involved in multiple steps of the HIV-1 replication cycle. CYPA regulates restriction many host factors by interacting with CYPA-binding loop on capsid (CA) surface. TRIM5 (tripartite motif protein 5) primates a key species-specific factor defining pandemic. incomplete adaptation to humans due different utilization pandemic and non-pandemic HIV-1. enzymatic activity viral core likely an important reason for regulating activity. Thus, its interaction may serve new targets future anti-AIDS therapeutic agents. This article will describe species-specificity TRIM5, understand role retroviral infection, discuss research issues.

Language: Английский

Citations

0
Regulation of Mitochondria-Derived Immune Activation by ‘Antiviral’ TRIM Proteins DOI Creative Commons
Seeun Oh, Michael A. Mandell

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1161 - 1161

Published: July 19, 2024

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the assembly and activation innate immune-signaling complexes. In response to viral infection, mitochondria can be triggered release immune-stimulatory molecules boost interferon production. These same released by damaged induce pathogenic, antiviral-like immune in absence infection. This review explores how members tripartite motif-containing (TRIM) protein family, which recognized their roles defense, regulate mitochondria-based activation. TRIMs essential components signal transduction pathways function directly acting restriction factors. carry out conceptually similar activities when controlling related mitochondria. First, they modulate activated mitochondrial molecules. Second, co-ordinate direct removal associated immune-activating factors through mitophagy. insights broaden scope TRIM actions immunity may implicate diseases with mitochondria-derived inflammation.

Language: Английский

Citations

2