Rolle des Hypothalamus bei der Steuerung des Essverhaltens DOI
Matthäus Metz, Henning Fenselau

Gynäkologische Endokrinologie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system DOI Creative Commons
Harold L. Haun,

RAUL HERNANDEZ,

Luzi Yan

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115482 - 115482

Published: March 29, 2025

Language: Английский

Citations

0
Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis DOI Creative Commons
Marie H. Solheim, Sima Stroganov, Weiyi Chen

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Generation of human appetite-regulating neurons and tanycytes from stem cells DOI

Zehra Abay-Nørgaard,

Anika K. Mueller,

Erno Hänninen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Summary The balance between energy intake and expenditure is controlled by the hypothalamus, a small brain region characterised high neuronal diversity. Specifically, arcuate nucleus (ARC) ventromedial hypothalamus (VMH) are key hypothalamic nuclei controlling appetite through behavioural response to circulating humoral signals. Yet, despite their physiological importance, cellular functional characteristics of this highly specialised neural has been studied mainly in animals due lack human models. Here, we fine-tuned differentiation pluripotent stem cells toward ARC VMH identified subtype-specific progenitor markers these subregions. We demonstrate that timing for initiation termination bone morphogenetic protein (BMP) signalling essential subregional specification tuberal progenitors along anterior-posterior axis, balancing versus fates. A particular population SHH - /NKX2.1 + /FGF10 /RAX /TBX3 posterior was as source generation ARC-associated agouti-related peptide (AGRP) neurons tanycytes whilst anterior low generated phenotypes including NR5A1 neurons. Upon maturation vitro xenografts, ARC-patterned gave rise appetite-regulating cell types those producing AGRP, prepronociceptin (PNOC), growth hormone-releasing hormone (GHRH), thyrotropin-releasing (TRH) pro-opiomelanocortin (POMC), well tanycyte glial cells. Differentiated cultures showed transcriptomic similarity displayed evidence functionality AGRP secretion responsiveness leptin fibroblast factor 1 (FGF1). In summary, our work provides insights into developmental lineages underlying enables access cultures, which will provide novel opportunities investigating molecular pathways triggered obesity-associated genetic variants weight-regulating stimuli.

Language: Английский

Citations

0
Rolle des Hypothalamus bei der Steuerung des Essverhaltens DOI
Matthäus Metz, Henning Fenselau

Gynäkologische Endokrinologie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Citations

0