Functional and Structural Connectivity of the subregions of the Amygdala in ADHD children with or without ODD
Abstract
Objectives
The
current
study
aimed
to
investigate
the
structural
and
functional
connectivity
of
subregions
amygdala
in
children
with
Attention
Deficit/Hyperactivity
Disorder
(ADHD)
only
or
comorbid
Oppositional
Defiant
(ODD).
Methods
A
total
354
ADHD-only,
161
ADHD
ODD
(ADHD
+
ODD)
100
healthy
controls
were
enrolled.
Several
rating
scales
filled
out
by
caregivers.
Analysis
covariance
(ANCOVA)
was
performed
test
group-wise
differences
these
behavioral
measures.
subsample
comprising
209
participants
went
through
a
resting-state
MRI
scan
Diffusion
Tensor
Imaging
(DTI)
scan.
Functional
calculated
using
bilateral
Amygdala
as
seeds.
Between-group
voxel-wise
comparisons
conducted.
Results
group
had
more
anxious/depressed
moods,
delinquent
aggressive
behaviors,
emotional
control
problems,
inhibition
deficits
than
ADHD-only
(all
P Bonferroni−corrected
<
0.05).
Compared
groups,
displayed
increased
FC
strength
between
left
caudate,
putamen,
frontal
cortex.
Regarding
(SC),
demonstrated
higher
streamline
density
internal
capsule,
corpus
callosum,
right
superior
corona
radiata.
altered
SC
associated
problems
ADHD,
while
other
ADHD-related
clinical
features.
Conclusions
Altered
compared
their
counterparts
respectively
problems.
Clinical
trial
number
not
applicable
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 29, 2024
Language: Английский