Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease DOI Creative Commons
Diao Yu, Zixiao Yin, Baotian Zhao

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106830 - 106830

Published: Feb. 1, 2025

This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. After presurgical speech analysis, we recorded STN neuronal activities while PD (n = 16) articulated Chinese Pinyin consonants. The consonants were categorized by manner place of articulation for SUA cluster analysis. cohort was then divided into normal dysarthria groups based diadochokinetic (DDK) assessments. patterns, represented mean firing rate (FR), peak time, response intensity during articulation, analyzed compared between two groups. Finally, a 7 included to test pattern changes following intraoperative DBS. Clustering analysis patterns demonstrated that neurons encode grouping same distinct clusters. Using k-means clustering, further classified SUAs waveform types: negative spikes (type 1) positive 2). Dysarthria exhibited an increased FR type 1 reduced 2 spikes. During stimulation, showed accelerated DDK, accompanied decrease increase FR. Our findings indicate crucial role consonant encoding at level. Both DDK performance can be modulated

Language: Английский

Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease DOI Creative Commons
Diao Yu, Zixiao Yin, Baotian Zhao

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106830 - 106830

Published: Feb. 1, 2025

This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. After presurgical speech analysis, we recorded STN neuronal activities while PD (n = 16) articulated Chinese Pinyin consonants. The consonants were categorized by manner place of articulation for SUA cluster analysis. cohort was then divided into normal dysarthria groups based diadochokinetic (DDK) assessments. patterns, represented mean firing rate (FR), peak time, response intensity during articulation, analyzed compared between two groups. Finally, a 7 included to test pattern changes following intraoperative DBS. Clustering analysis patterns demonstrated that neurons encode grouping same distinct clusters. Using k-means clustering, further classified SUAs waveform types: negative spikes (type 1) positive 2). Dysarthria exhibited an increased FR type 1 reduced 2 spikes. During stimulation, showed accelerated DDK, accompanied decrease increase FR. Our findings indicate crucial role consonant encoding at level. Both DDK performance can be modulated

Language: Английский

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