HKDC1 promotes autophagy and proliferation in pancreatic adenocarcinoma through interaction with PARP1 and poly(ADP-ribosyl)ation DOI
Qiang Pang,

Shansong Huang,

Huiying Wang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111474 - 111474

Published: Oct. 16, 2024

Language: Английский

Topoisomerase 3A (TOP3A) Dependent Alternative Lengthening of Telomeres (ALT) DOI Open Access
Prashant Khandagale, Yilun Sun,

Sourav Saha

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Alternative Lengthening of Telomeres (ALT) is a homologous recombination-dependent telomere elongation mechanism utilized by at least 10-15% all cancers. Here we identified that the DNA topoisomerase, TOP3A enriched telomeres ALT cells but not telomerase-positive (Tel) cancer cells. We demonstrate stabilizes shelterin protein TERF2 in cell lines Tel and long non-coding transcribed RNA (TERRA) enrichment depends upon TOP3A. also promotes generation single-stranded telomeric C-strand (ssTeloC) DNA, which recently discovered marker for ALT. Additionally, found inducing TOP3A-DNA-protein crosslinks suppresses TERRA as well destabilizes TERF2. Taken together these observations uncover unexplored functions suggest potential developing an ALT-specific therapeutic strategy targeting

Language: Английский

Citations

2
HKDC1 promotes autophagy and proliferation in pancreatic adenocarcinoma through interaction with PARP1 and poly(ADP-ribosyl)ation DOI
Qiang Pang,

Shansong Huang,

Huiying Wang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111474 - 111474

Published: Oct. 16, 2024

Language: Английский

Citations

0