Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 5, 2025

The tumour microenvironment is the "hotbed" of cells, providing abundant extracellular support for growth and metastasis. However, not static constantly remodelled by a variety cellular components, including through mechanical, biological chemical means to promote Focal adhesion plays an important role in cell-extracellular matrix adhesion. An in-depth exploration focal metastasis, especially their contribution at biomechanical level, direction current research. In this review, we first summarize assembly adhesions explore kinetics cells. Then, describe detail various stages its key functions cell migration, invasion, remodelling. Finally, anti-tumour strategies targeting progress development some inhibitors against proteins. paper, time that play positive feedback pro-tumour metastatic remodelling summarizing five processes multidimensional way. It beneficial researchers have deeper understanding behaviour metastasis potential as therapeutic target, new ideas prevention treatment metastases.

Language: Английский

Chronic exposure to polystyrene microplastics triggers osteoporosis by breaking the balance of osteoblast and osteoclast differentiation

Toxicology, Journal Year: 2024, Volume and Issue: 510, P. 154017 - 154017

Published: Nov. 27, 2024

Language: Английский