Polymicrobial detection and salivary metabolomics of children with early childhood caries

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19399 - e19399

Published: May 6, 2025

Background Early childhood caries (ECC) has been proposed to be associated with various microorganisms and metabolites. This study aims compare the prevalence of specific microbial species salivary metabolomics profile in children without ECC, explore correlation between metabolites targeted microbes. Method Five ml unstimulated saliva was collected from 32 ECC 22 caries-free children. Clinical indexed were recorded questionnaires regarding oral health dietary habits obtained guardians. The presence eight examined using species-specific quantitative PCR (qPCR). Untargeted analyzed identify key differential pathways. Correlations among clinical, microbial, metabolomic data further explored. Results Scardovia wiggsiae (90.6%, P < 0.001), Streptococcus mutans (43.8%, = 0.006), sobrinus (62.5%, Ligilactobacillus salivarius (93.6%, 0.01) Candida albicans (56.3%, 0.001) significantly higher group. two present compared one species. Histidine metabolism branched-chain amino acids degradation activated group, while glyoxylate dicarboxylate metabolism, purine pyrimidine inhibited. glutathione enrichment species, linoleic acid biotin duration each toothbrushing a significant risk factor for experience. Conclusion wiggsiae, mutans, is Oral also vary

Language: Английский

Availability of preventive dental services to preschool and school children within the public health sector in the canton of Sarajevo

Srpski medicinski casopis Lekarske komore, Journal Year: 2024, Volume and Issue: 5(4), P. 523 - 535

Published: Jan. 1, 2024

Introduction: Oral health is a segment of general human reflected in the condition oral tissues, which contributes to overall physical, psychological and social well-being, enabling people eat, communicate participate life without discomfort, inconvenience or stress. This study aims determine frequency conducting regular dental examinations early childhood, practice parents/ guardians process preserving children's health, as well satisfaction with services provided. Materials methods: The was conducted cross-sectional, descriptive comparative at Primary Healthcare Center Canton Sarajevo. Heads service users were respondents study. included five heads 209 parents who participated via an online Google forms survey that based on original questionnaire designed by authors. Results: availability care high level according parents, it determined be available 139 66.5% cases. Only 24 11.7% stated they do not have access care. Most did wait for examination their children satisfied accessibility staff, giving score 4.14 ± 1.21 scale 1 5. Conclusion: Based results study, we able prove quality safe preventive preschool school public sector provided professionalism, work staff.

Language: Английский