The utility of nonhuman primate models for understanding acute HIV-1 infection
Current Opinion in HIV and AIDS,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Purpose
of
review
Nonhuman
primate
(NHP)
models
HIV-1
infection
provide
complementary
experimental
pathways
for
assessing
aspects
acute
(AHI)
that
cannot
be
addressed
in
humans.
This
article
reviews
studies
SIV-infected
or
SHIV-infected
macaque
species
over
the
previous
18
months.
Recent
findings
Reviewed
examined
dynamics
replication-competent
viral
reservoir
establishment
during
early
infection,
maintenance
throughout
therapy,
and
factors
influencing
rebound
after
treatment
cessation.
Also
discussed
are
events
central
nervous
system
liver
potential
links
between
these
manifestations
comorbidities
chronic
infection.
Additional
how
occurrences
impact
development
natural
control
posttreatment
control.
Another
report
evaluated
with
broadly
neutralizing
antibodies
enhanced
ability
to
engage
innate
immune
cells,
highlighting
this
intervention
shape
adaptive
antiviral
responses.
Summary
NHP
a
fundamental
research
tool
investigating
AHI
events.
These
enable
detailed
pathogenesis
characterization
testing
hypothesis-driven
strategies
altering
disease
courses
through
interventions
AHI,
including
targeting
persistence
persist
Language: Английский
Pigtail Macaque (Macaca nemestrina) Performance Differs Across Multiple Cognitive Domains in Comparison to Rhesus Macaques (Macaca mulatta)
Isabella M. Baumann,
No information about this author
Bess Carlson,
No information about this author
Jasmine Hadeed
No information about this author
et al.
American Journal of Primatology,
Journal Year:
2025,
Volume and Issue:
87(4)
Published: April 1, 2025
ABSTRACT
Rhesus
and
pigtail
macaques
are
closely
related
have
similar
social
structures,
yet
differences
in
their
behavior,
socio‐ecology,
personality
been
observed,
although
not
systematically
documented.
Given
these
differences,
it
is
important
to
assess
macaque
cognition
independently,
rather
than
relying
on
rhesus
findings
as
a
proxy.
To
gain
better
understanding
of
cognition,
we
used
battery
three
cognitive
tasks.
were
tested
the
same
tasks
validate
our
methods
allow
for
comparison.
Across
just
tasks,
found
significant
between
two
species.
In
cups
task,
which
tests
short‐term
memory,
both
performed
significantly
when
they
had
recall
location
hidden
food
reward
after
0
s
delay
compared
15
delay.
However,
condition,
only
above
chance
levels,
whereas
did
not.
reversal
learning
rule
flexibility,
species
performance.
For
quantity
discrimination
numerosity,
that
more
accurate
at
discriminating
"easy"
ratios
foods
(e.g.,
1
vs.
5
or
2
6)
"hard"
3
4
5).
hard
ratio
trials.
These
contribute
novel
while
also
increasing
research
rigor
translational
research.
Language: Английский