Pigtail Macaque (Macaca nemestrina) Performance Differs Across Multiple Cognitive Domains in Comparison to Rhesus Macaques (Macaca mulatta) DOI

Isabella M. Baumann,

Bess Carlson,

Jasmine Hadeed

et al.

American Journal of Primatology, Journal Year: 2025, Volume and Issue: 87(4)

Published: April 1, 2025

ABSTRACT Rhesus and pigtail macaques are closely related have similar social structures, yet differences in their behavior, socio‐ecology, personality been observed, although not systematically documented. Given these differences, it is important to assess macaque cognition independently, rather than relying on rhesus findings as a proxy. To gain better understanding of cognition, we used battery three cognitive tasks. were tested the same tasks validate our methods allow for comparison. Across just tasks, found significant between two species. In cups task, which tests short‐term memory, both performed significantly when they had recall location hidden food reward after 0 s delay compared 15 delay. However, condition, only above chance levels, whereas did not. reversal learning rule flexibility, species performance. For quantity discrimination numerosity, that more accurate at discriminating "easy" ratios foods (e.g., 1 vs. 5 or 2 6) "hard" 3 4 5). hard ratio trials. These contribute novel while also increasing research rigor translational research.

Language: Английский

The utility of nonhuman primate models for understanding acute HIV-1 infection DOI
Matthew S. Parsons, Diane L. Bolton

Current Opinion in HIV and AIDS, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Purpose of review Nonhuman primate (NHP) models HIV-1 infection provide complementary experimental pathways for assessing aspects acute (AHI) that cannot be addressed in humans. This article reviews studies SIV-infected or SHIV-infected macaque species over the previous 18 months. Recent findings Reviewed examined dynamics replication-competent viral reservoir establishment during early infection, maintenance throughout therapy, and factors influencing rebound after treatment cessation. Also discussed are events central nervous system liver potential links between these manifestations comorbidities chronic infection. Additional how occurrences impact development natural control posttreatment control. Another report evaluated with broadly neutralizing antibodies enhanced ability to engage innate immune cells, highlighting this intervention shape adaptive antiviral responses. Summary NHP a fundamental research tool investigating AHI events. These enable detailed pathogenesis characterization testing hypothesis-driven strategies altering disease courses through interventions AHI, including targeting persistence persist

Language: Английский

Citations

0
Pigtail Macaque (Macaca nemestrina) Performance Differs Across Multiple Cognitive Domains in Comparison to Rhesus Macaques (Macaca mulatta) DOI

Isabella M. Baumann,

Bess Carlson,

Jasmine Hadeed

et al.

American Journal of Primatology, Journal Year: 2025, Volume and Issue: 87(4)

Published: April 1, 2025

ABSTRACT Rhesus and pigtail macaques are closely related have similar social structures, yet differences in their behavior, socio‐ecology, personality been observed, although not systematically documented. Given these differences, it is important to assess macaque cognition independently, rather than relying on rhesus findings as a proxy. To gain better understanding of cognition, we used battery three cognitive tasks. were tested the same tasks validate our methods allow for comparison. Across just tasks, found significant between two species. In cups task, which tests short‐term memory, both performed significantly when they had recall location hidden food reward after 0 s delay compared 15 delay. However, condition, only above chance levels, whereas did not. reversal learning rule flexibility, species performance. For quantity discrimination numerosity, that more accurate at discriminating "easy" ratios foods (e.g., 1 vs. 5 or 2 6) "hard" 3 4 5). hard ratio trials. These contribute novel while also increasing research rigor translational research.

Language: Английский

Citations

0