A nociceptive amygdala-striatal pathway for chronic pain aversion

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

The basolateral amygdala (BLA) is essential for assigning positive or negative valence to sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of

Language: Английский

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Assessing the role of BNST GABA neurons in backward conditioned suppression

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

ABSTRACT Conditioned suppression is a useful paradigm for measuring learned avoidance. In most conditioned studies, forward conditioning used where cue predicts an aversive stimulus. However, backward conditioning, in which stimulus cue, provides unique insights into avoidance due to its influence on both excitation and inhibition. We trained mice consume sucrose context A, associated B few or many backwards paired cues (CS+), then tested A response the CS+. found that CS+ produced suppression, but did not. Administration of diazepam, positive allosteric modulator GABA-A receptor, prevented not Furthermore, freezing behavior was observed CS+, diazepam had no effect locomotion. next examined BNST GABA neurons potential sensitivity suppression. VGaT signaling increased licks during outside onset offset. Using designer receptors, we neuron activation, inhibition, expression. conclude dependent modulation receptors by neurons.

Language: Английский

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Assessing the role of BNST GABA neurons in backward conditioned suppression

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: 219, P. 108058 - 108058

Published: May 1, 2025

Language: Английский

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Subanesthetic propofol alleviates chronic stress-induced anxiety by enhancing VTADA neurons’ activity

Neuropharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 110264 - 110264

Published: Dec. 1, 2024

Language: Английский

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