The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract In many brain regions, inhibitory interneurons represent a highly diverse class of cells, and the specific roles most subtypes remain unclear. This diversity is particularly striking in retina, where amacrine primary interneurons, form population, with nearly 67 mice. Recent methodological advances have provided unprecedented insight into this complexity. Techniques such as transcriptomics, connectomics targeted electrophysiological recordings made it possible to isolate characterize individual cell types. Here, we review current knowledge cells discuss how emerging approaches are advancing our understanding their function, focus on mouse retina. Several can now be genetically targeted, allowing for detailed study morphology light responses. A promising avenue research investigating these process complex stimuli whether responses vary across different dendritic compartments. Amacrine play fundamental role visual computations, often through dedicated circuit motifs. However, subtypes, contributions motifs unknown. key open question function independent units within distinct circuits or if they interconnected broader, recurrent network. Answering will essential understand contribute retinal processing fully. image

Language: Английский