Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses DOI Creative Commons
Young‐Jun Park, Chen Liu, Jimin Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity with which engage ACE2 their species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing Pipistrellus abramus (P.abr) several non-bat mammalian ACE2s through binding mode distinct from any other known ACE2-using coronaviruses. These results show merbecovirus clades independently evolved utilization, appears to be broadly shared property among these pathogens, an extraordinary recognition modes. We MERS-CoV have markedly antigenicity, due extensive genetic divergence, identified inhibitors, including two clinical compounds. Our findings profoundly alter our understanding coronavirus evolution pave way developing countermeasures against viruses poised human emergence.

Language: Английский

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses DOI
Young‐Jun Park, Chen Liu, Jimin Lee

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

5
Engineered DPP4 decoy confers broad-spectrum inhibition of MERS-CoV infection DOI Creative Commons

Keisuke Nishioka,

Yusuke Sakai, Daisuke Motooka

et al.

Published: March 1, 2025

Language: Английский

Citations

0
Self-Assembling protein nanoparticle platform for multivalent antigen delivery in vaccine development DOI

Hao Wu,

Ruiqi Weng,

Jiaxuan Li

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125597 - 125597

Published: April 1, 2025

Language: Английский

Citations

0
Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses DOI Creative Commons
Young‐Jun Park, Chen Liu, Jimin Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity with which engage ACE2 their species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing Pipistrellus abramus (P.abr) several non-bat mammalian ACE2s through binding mode distinct from any other known ACE2-using coronaviruses. These results show merbecovirus clades independently evolved utilization, appears to be broadly shared property among these pathogens, an extraordinary recognition modes. We MERS-CoV have markedly antigenicity, due extensive genetic divergence, identified inhibitors, including two clinical compounds. Our findings profoundly alter our understanding coronavirus evolution pave way developing countermeasures against viruses poised human emergence.

Language: Английский

Citations

2