The Emerging Role and Clinical Significance of PI3K-Akt-mTOR in Rhabdomyosarcoma DOI Creative Commons
Ilaria Versari, Sara Salucci, Alberto Bavelloni

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 334 - 334

Published: Feb. 25, 2025

Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma primarily affecting children and young adults. This disease more prevalent in under 15, with two main types: embryonal (eRMS), which has better prognosis, alveolar (aRMS), aggressive associated specific genetic alterations. The PI3K-Akt-mTOR pathway often hyperactivated RMS, contributing to cell proliferation, survival, resistance therapies. presence of phosphorylated components this correlates poor survival outcomes. Here, we discuss various therapeutic approaches targeting the pathway. These include use inhibitors (e.g., PI3K inhibitors, Akt inhibitors) combination therapies that may enhance treatment efficacy. Dietary supplements like curcumin repurposed drugs such as chloroquine are also mentioned for their potential induce apoptosis RMS cells. We emphasize need innovative strategies improve rates, have remained stagnant over years. Targeting super-enhancers transcription factors provide new avenues. Overall, review underscores critical role targeted patient

Language: Английский

The Emerging Role and Clinical Significance of PI3K-Akt-mTOR in Rhabdomyosarcoma DOI Creative Commons
Ilaria Versari, Sara Salucci, Alberto Bavelloni

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 334 - 334

Published: Feb. 25, 2025

Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma primarily affecting children and young adults. This disease more prevalent in under 15, with two main types: embryonal (eRMS), which has better prognosis, alveolar (aRMS), aggressive associated specific genetic alterations. The PI3K-Akt-mTOR pathway often hyperactivated RMS, contributing to cell proliferation, survival, resistance therapies. presence of phosphorylated components this correlates poor survival outcomes. Here, we discuss various therapeutic approaches targeting the pathway. These include use inhibitors (e.g., PI3K inhibitors, Akt inhibitors) combination therapies that may enhance treatment efficacy. Dietary supplements like curcumin repurposed drugs such as chloroquine are also mentioned for their potential induce apoptosis RMS cells. We emphasize need innovative strategies improve rates, have remained stagnant over years. Targeting super-enhancers transcription factors provide new avenues. Overall, review underscores critical role targeted patient

Language: Английский

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