A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

The dynamic interaction between central respiratory chemoreceptors and the pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm pattern, yet its circuit-level organization remains poorly characterized. Here, functional connectivity two key medullary hubs: nucleus tractus solitarius (NTS) preBötzinger complex (preBötC) are systematically investigated. These findings delineate network primarily comprising Phox2b-expressing NTS neurons (NTSPhox2b), GABAergic (NTSGABA), somatostatin (SST)-expressing preBötC (preBötCSST). Photostimulation of NTSPhox2b projecting to potently amplifies baseline ventilation, whereas genetic ablation these or knockout their transient receptor potential channel 5 (TRPC5) significantly blunts CO2-stimulated ventilatory responses. Conversely, NTSGABA neuron stimulation inhibits halts partially via monosynaptic inhibition preBötC. Additionally, photostimulation preBötCSST drives deep slow through coordinated modulation neurons. collectively identify an important that integrates chemosensory feedback with motor output, enabling tuning patterns metabolic demands.

Language: Английский

GABAergic neurons in central amygdala contribute to orchestrating anxiety-like behaviors and breathing patterns

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 14, 2025

Language: Английский