Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review DOI Creative Commons
Chunling Wang, Jia‐Shu Yang, Junying Yuan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell human body adheres to specific circadian governing various processes essential for overall health. REV-ERB, key clock-regulating gene, plays crucial role maintaining precision these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health well-being are increasingly challenged disruptions such as night shifts, late-night activities, jet lag. These often lead rhythm disorders, which now being linked heart diseases. review explored potential cardiovascular system. Beyond its regulation, could significantly influence physiological pathological related health, atherosclerosis, ischemia/reperfusion injury, failure. Mechanistically, regulate glucose lipid ferroptosis, mitochondrial function. The highlighted protective roles underlying mechanisms diseases, suggesting multidisciplinary research may provide basis breakthroughs REV-ERB-targeted therapies disorders.

Language: Английский

Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review DOI Creative Commons
Chunling Wang, Jia‐Shu Yang, Junying Yuan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell human body adheres to specific circadian governing various processes essential for overall health. REV-ERB, key clock-regulating gene, plays crucial role maintaining precision these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health well-being are increasingly challenged disruptions such as night shifts, late-night activities, jet lag. These often lead rhythm disorders, which now being linked heart diseases. review explored potential cardiovascular system. Beyond its regulation, could significantly influence physiological pathological related health, atherosclerosis, ischemia/reperfusion injury, failure. Mechanistically, regulate glucose lipid ferroptosis, mitochondrial function. The highlighted protective roles underlying mechanisms diseases, suggesting multidisciplinary research may provide basis breakthroughs REV-ERB-targeted therapies disorders.

Language: Английский

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