A burst-dependent thalamocortical substrate for perceptual awareness DOI Creative Commons
Christopher J. Whyte, Eli J. Műller, Jaan Aru

et al.

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(4), P. e1012951 - e1012951

Published: April 7, 2025

Contemporary models of perceptual awareness lack tractable neurobiological constraints. Inspired by recent cellular recordings in a mouse model tactile threshold detection, we constructed biophysical that incorporated essential features thalamocortical anatomy and physiology. Our reproduced, mechanistically explains, the key vivo neural behavioural signatures model, as well response to set causal perturbations. We generalised same (with identical parameters) more complex task – visual rivalry found thalamic-mediated mechanism determined dominance. This led generation novel, directly testable, electrophysiological predictions. Analyses based on dynamical systems theory show simulations both detection arises from emergent systems-level dynamics loops.

Language: Английский

A burst-dependent thalamocortical substrate for perceptual awareness DOI Creative Commons
Christopher J. Whyte, Eli J. Műller, Jaan Aru

et al.

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(4), P. e1012951 - e1012951

Published: April 7, 2025

Contemporary models of perceptual awareness lack tractable neurobiological constraints. Inspired by recent cellular recordings in a mouse model tactile threshold detection, we constructed biophysical that incorporated essential features thalamocortical anatomy and physiology. Our reproduced, mechanistically explains, the key vivo neural behavioural signatures model, as well response to set causal perturbations. We generalised same (with identical parameters) more complex task – visual rivalry found thalamic-mediated mechanism determined dominance. This led generation novel, directly testable, electrophysiological predictions. Analyses based on dynamical systems theory show simulations both detection arises from emergent systems-level dynamics loops.

Language: Английский

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