Low-cost optical sensors in electrified lab-on-a-disc platforms: liquid-phase boundary detection and automated diagnostics

Microsystems & Nanoengineering, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 7, 2025

Abstract Centrifugal microfluidic platforms are highly regarded for their potential in multiplexing and automation, as well wide range of applications, especially separating blood plasma manipulating two-phase flows. However, the need to use stroboscopes or high-speed cameras monitoring these tasks hinders extensive research commercial settings. In this study, we introduce an innovative cost-effective strategy using array light-dependent resistors (LDRs) optical sensors devices, particularly centrifugal platforms. While LDRs attractive photodetectors, bulky size frequently restricts ability provide high-resolution detection systems. Here, specific waveguides direct light beams from narrow apertures onto surface LDRs. We integrated into electrified Lab-on-a-Disc (eLOD) with wireless connectivity smartphones laptops. This enables many such droplet/particle counting velocity measurement, concentration analysis, fluidic interface multiphase flows, real-time sample volume on platforms, separation alternative costly stroboscope microscopes, imaging. used numerical simulations evaluate various fluids scenarios, which include rotation speeds up 50 rad/s a droplet sizes. For testbed, developed eLOD device analyze red cell (RBC) deformability improve automated sickle anemia by differences RBC during centrifugation sensors’ signals. addition anemia, has facilitate low-cost other medical conditions characterized altered deformability, thalassemia, malaria, diabetes.

Language: Английский

Particle separation using surface acoustic waves based on microfluidic chip

Chaos Solitons & Fractals, Journal Year: 2025, Volume and Issue: 198, P. 116557 - 116557

Published: May 16, 2025

Language: Английский

Cell/particle Manipulation Using Bulk Acoustic Waves (BAWs) on Centrifugal Microfluidic Platforms: a mathematical study

Chemical Engineering and Processing - Process Intensification, Journal Year: 2024, Volume and Issue: unknown, P. 110024 - 110024

Published: Oct. 1, 2024

Language: Английский