Characterization and Comparative Investigation of Hydroxyapatite/Carboxymethyl Cellulose (CaHA/CMC) Matrix for Soft Tissue Augmentation in a Rat Model DOI Creative Commons
Erkan Karataş, Kübra Koç, Mehmet Yılmaz

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(29), P. 31586 - 31600

Published: July 12, 2024

This study endeavors to develop an injectable subdermal implant material tailored for soft tissue repair and enhancement. The consists of a ceramic phase calcium hydroxyapatite (CaHA), which is biocompatible, 20–60 μm in size, known its biocompatibility minimal likelihood causing foreign body reactions, antigenicity, inflammatory response, dispersed carrier composed carboxymethyl cellulose (CMC), glycerol, water injection. gel formulation underwent comprehensive characterization via various analytical techniques. X-ray diffraction (XRD) was employed identify crystalline phases investigate the structural properties particles, while thermogravimetric analysis (TGA) conducted evaluate thermal stability decomposition behavior final formulation. Scanning electron microscopy (SEM) utilized examine surface morphology particle size distribution, confirming homogeneous dispersion spherical CaHA particles within matrix. SEM revealed sizes ranging from approximately μm. Elemental confirmed stoichiometric Ca/P ratio 1.65 (HA) structure. Heavy metal content exhibited suitability surgical use without posing toxicity risks. Rheological storage modulus 58.6 68.9 kPa loss 21.7 24.8 at frequencies 2 5 Hz, respectively. 150 μL sterilized CaHA/CMC injected subcutaneously into rats compared with similar product, Crystalys, assess effects on tissues. Skin samples were collected specific intervals throughout (30, 45, 60, 90 120 days), examined histologically. Results demonstrated that led significant increase dermal thickness, elastic fibers, collagen density. Based findings, formulated found be biodegradable, nonimmunogenic, nontoxic, safe, effective, represents promising option augmentation.

Language: Английский

Biomimetic porous HA bone scaffolds doped with 58S: DLP additive manufacturing, microstructure and performance DOI
Wang Guo, Ping Li, Yuanjie Pang

et al.

Composites Part A Applied Science and Manufacturing, Journal Year: 2025, Volume and Issue: unknown, P. 108870 - 108870

Published: March 1, 2025

Language: Английский

Citations

0
Effect of different forms of SiO2 nanoparticles on the performance of 3D-printed Poly(lactic acid) composites DOI
Ning Ma,

J.H. Chen,

Ziyang Chen

et al.

Journal of Polymer Research, Journal Year: 2025, Volume and Issue: 32(5)

Published: April 21, 2025

Language: Английский

Citations

0
3D chitosan/hydroxyapatite scaffolds containing mesoporous SiO2-HA particles: A new step to healing bone defects DOI

Nesa Abdian,

Hamid Soltani Zangbar,

Mohamadreza Etminanfar

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 135014 - 135014

Published: Aug. 23, 2024

Language: Английский

Citations

1
Characterization and Comparative Investigation of Hydroxyapatite/Carboxymethyl Cellulose (CaHA/CMC) Matrix for Soft Tissue Augmentation in a Rat Model DOI Creative Commons
Erkan Karataş, Kübra Koç, Mehmet Yılmaz

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(29), P. 31586 - 31600

Published: July 12, 2024

This study endeavors to develop an injectable subdermal implant material tailored for soft tissue repair and enhancement. The consists of a ceramic phase calcium hydroxyapatite (CaHA), which is biocompatible, 20–60 μm in size, known its biocompatibility minimal likelihood causing foreign body reactions, antigenicity, inflammatory response, dispersed carrier composed carboxymethyl cellulose (CMC), glycerol, water injection. gel formulation underwent comprehensive characterization via various analytical techniques. X-ray diffraction (XRD) was employed identify crystalline phases investigate the structural properties particles, while thermogravimetric analysis (TGA) conducted evaluate thermal stability decomposition behavior final formulation. Scanning electron microscopy (SEM) utilized examine surface morphology particle size distribution, confirming homogeneous dispersion spherical CaHA particles within matrix. SEM revealed sizes ranging from approximately μm. Elemental confirmed stoichiometric Ca/P ratio 1.65 (HA) structure. Heavy metal content exhibited suitability surgical use without posing toxicity risks. Rheological storage modulus 58.6 68.9 kPa loss 21.7 24.8 at frequencies 2 5 Hz, respectively. 150 μL sterilized CaHA/CMC injected subcutaneously into rats compared with similar product, Crystalys, assess effects on tissues. Skin samples were collected specific intervals throughout (30, 45, 60, 90 120 days), examined histologically. Results demonstrated that led significant increase dermal thickness, elastic fibers, collagen density. Based findings, formulated found be biodegradable, nonimmunogenic, nontoxic, safe, effective, represents promising option augmentation.

Language: Английский

Citations

0