Biomechanical and histomorphometric evaluation of biodegradable mini-implants for orthodontic anchorage in the mandible of beagle dogs DOI Creative Commons
Shuo Wang, Zuodong Zhao, Q Zhang

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 10, 2025

To evaluate the effectiveness of a mini-implant composed unsintered hydroxyapatite, poly (L-lactic acid) and poly(lactic-co-glycolic (u-HA/PLLA/PLGA) composites as an anchorage device under consistent orthodontic force (OF) loading in vivo. An mandible model beagle dogs was introduced. 144 mini-implants were implanted both sides mandibles. The experimental group (left side) loaded at magnitude 200 g to simulate OF. At 2, 4 6 months after implantation, tissue specimens taken from sites biomechanical, histological histomorphometrical analysis performed. Mini-implants with highest PLLA ratio showed 27% non-fracture rate 20.83% dogs, non-fractured could maintain tensile g, while other two groups all fractured. Histomorphological that there no significant relationship between Bone Volume over Total (BV/TV) implantation time among most groups. level Bone-Implant Contact (BIC) Medium Low decreased gradually 2 months. This study biodegradable work alternative titanium alloy by adjusting proportion its ingredients. Degradable for lie their potential revolutionize treatments offering minimizes need secondary surgeries removal, thereby enhancing patient comfort reducing overall treatment time.

Language: Английский

Cuttlefish-Bone-Derived Hybrid Composite Scaffolds for Bone Tissue Engineering DOI Creative Commons

Vignesh Raj Sivaperumal,

S. Sutha,

Ramalingam Manikandan

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(3), P. 196 - 196

Published: Jan. 26, 2025

Current investigations into the fabrication of innovative biomaterials that stimulate cartilage development result from increasing interest due to emerging bone defects. In particular, investigation for musculoskeletal therapies extensively depends on various hydroxyapatite (HA)/sodium alginate (SA) composites. Cuttlefish (CFB)-derived composite scaffolds hard tissue regeneration have been effectively illustrated in this using a hydrothermal technique. this, HA was prepared CFB source without altering its biological properties. The as-developed nanocomposites were investigated through XRD, FTIR, SEM, and EDX analyses confirm their structural, functional, morphological orientation. higher interfacial density HA/SA nanocomposites, more hardness scaffold increased with applied load. Furthermore, nanocomposite revealed remarkable antibacterial activity against bacterial strains such as E. coli S. aureus inhibition zones measured 18 mm 20 mm, respectively. results demonstrated minor decrease cell viability compared untreated culture, an observed percentage at 97.2% nanocomposites. Hence, proposed would be excellent alternative engineering applications.

Language: Английский

Citations

0
Enhancement of Osteogenic Potential and Surface wettability of Polycaprolactone using Hydroxyapatite co-doped with Vanadium and Yttrium DOI

M. Megha,

Anjumol Joy,

Chandni C. Mohan

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
New Three Dimensional-Printed Polyethylene Terephthalate Glycol Liners for Hip Joint Endoprostheses: A Bioactive Platform for Bone Regeneration DOI Open Access

Gheorghe Iosub,

Ioana-Alexandra Lungescu,

Alexandra Cătălina Bîrcă

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(6), P. 1206 - 1206

Published: March 8, 2025

Osteoporosis and bone defects are commonly observed in postmenopausal women, often linked to decreased folic acid levels, which play a crucial role metabolism regeneration. This study investigates 3D-printed polyethylene terephthalate glycol (PETG)-based porous scaffolds impregnated with chitosan (CS), hydroxyapatite (HAp), (FA) for tissue engineering applications. The PETG-CS scaffold serves as the primary structural framework, HAp incorporated enhance bioactivity through its osteoconductive osteoinductive properties. FA was included address potential deficiencies quality stimulate cellular differentiation. were fabricated using precise 3D printing techniques, yielding structures controlled porosity. Physicochemical analyses confirmed successful integration of into matrix. Biological evaluations preosteoblast cell lines demonstrated enhanced viability, proliferation, biocompatibility scaffolds. These findings highlight promising applications PETG-CS-HAp-FA engineering, providing platform future investigations personalized regenerative therapies.

Language: Английский

Citations

0
Biomechanical and histomorphometric evaluation of biodegradable mini-implants for orthodontic anchorage in the mandible of beagle dogs DOI Creative Commons
Shuo Wang, Zuodong Zhao, Q Zhang

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 10, 2025

To evaluate the effectiveness of a mini-implant composed unsintered hydroxyapatite, poly (L-lactic acid) and poly(lactic-co-glycolic (u-HA/PLLA/PLGA) composites as an anchorage device under consistent orthodontic force (OF) loading in vivo. An mandible model beagle dogs was introduced. 144 mini-implants were implanted both sides mandibles. The experimental group (left side) loaded at magnitude 200 g to simulate OF. At 2, 4 6 months after implantation, tissue specimens taken from sites biomechanical, histological histomorphometrical analysis performed. Mini-implants with highest PLLA ratio showed 27% non-fracture rate 20.83% dogs, non-fractured could maintain tensile g, while other two groups all fractured. Histomorphological that there no significant relationship between Bone Volume over Total (BV/TV) implantation time among most groups. level Bone-Implant Contact (BIC) Medium Low decreased gradually 2 months. This study biodegradable work alternative titanium alloy by adjusting proportion its ingredients. Degradable for lie their potential revolutionize treatments offering minimizes need secondary surgeries removal, thereby enhancing patient comfort reducing overall treatment time.

Language: Английский

Citations

0