International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1807 - 1807
Published: Feb. 2, 2024
The
relationship
between
gut
dysbiosis
and
body
mass
index
(BMI)
in
non-diabetic
patients
with
non-alcoholic
fatty
liver
disease
(NAFLD)
is
not
adequately
characterized.
This
study
aimed
to
assess
microbiota's
signature
individuals
NAFLD
stratified
by
BMI.
16S
ribosomal
RNA
sequencing
was
performed
for
microbiota
composition
100
16
healthy
individuals.
differential
abundance
of
bacterial
groups
analyzed
using
the
DESeq2
method.
alpha
diversity
(Chao1,
Shannon,
observed
feature)
beta
significantly
differed
controls.
However,
significant
differences
their
diversities
were
among
subgroups
NAFLD.
At
phylum
level,
there
no
trend
an
elevated
Medicina,
Journal Year:
2022,
Volume and Issue:
58(11), P. 1559 - 1559
Published: Oct. 30, 2022
Introduction:
Gut
microbiota
is
not
only
a
taxonomic
biologic
ecosystem
but
also
involved
in
human
intestinal
and
extra-intestinal
functions
such
as
immune
system
modulation,
nutrient
absorption
digestion,
well
metabolism
regulation.
The
latter
strictly
linked
to
non-alcoholic
fatty
liver
disease
(NAFLD)
pathophysiology.
Materials
methods:
We
reviewed
the
literature
on
definition
of
gut
microbiota,
concepts
"dysbiosis"
"eubiosis",
their
role
NAFLD
pathogenesis,
data
fecal
transplantation
(FMT)
these
patients.
consulted
main
medical
databases
using
following
keywords,
acronyms,
associations:
eubiosis,
dysbiosis,
bile
acids,
NAFLD,
FMT.
Results:
qualitative
quantitative
composition
different
healthy
subjects
vs.
NALFD
This
dysbiosis
associated
with
pathogenesis
evolution
non-acoholic
steatohepatitis
(NASH),
cirrhosis,
hepatocellular
carcinoma
(HCC).
In
detail,
microbial-driven
acids
(BAs)
interaction
hepatic
farnesoid
nuclear
X
receptor
(FXR)
have
shown
determinant
fat
deposition
development
fibrosis.
Over
use
pre-
or
probiotics,
FMT
has
preclinical
initial
clinical
promising
results
treatment
through
re-modulation
microbial
dysbiosis.
Conclusions:
Promising
support
larger
investigation
reversion
randomized
trials
design
precision-medicine
treatments
for
patients
at
stages.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(5), P. 1852 - 1852
Published: Feb. 26, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
serious
health
problem
due
to
its
high
incidence
and
consequences.
In
view
of
the
existing
controversies,
new
therapeutic
options
for
NAFLD
are
still
being
sought.
Therefore,
aim
our
review
was
evaluate
recently
published
studies
on
treatment
patients.
We
searched
articles
in
PubMed
database
using
appropriate
terms,
including
“non-alcoholic
disease”,
“nonalcoholic
“NAFLD”,
“diet”,
“treatment”,
“physical
activity”,
“supplementation”,
“surgery”,
“overture”
“guidelines”.
One
hundred
forty-eight
randomized
clinical
trials
from
January
2020
November
2022
were
used
final
analysis.
The
results
show
significant
benefits
therapy
associated
with
use
not
only
Mediterranean
but
also
other
types
diet
(including
low-calorie
ketogenic,
high-protein,
anti-inflammatory
whole-grain
diets),
as
well
enrichment
selected
food
products
or
supplements.
Significant
this
group
patients
moderate
aerobic
physical
training.
available
indicate,
above
all,
usefulness
drugs
related
weight
reduction,
reduction
insulin
resistance
lipids
level
antioxidant
properties.
dulaglutide
combination
tofogliflozin
pioglitazone
should
be
emphasized.
Based
latest
research,
authors
article
suggest
revision
recommendations
The Lancet Regional Health - Western Pacific,
Journal Year:
2023,
Volume and Issue:
37, P. 100803 - 100803
Published: May 31, 2023
Understanding
the
trajectories
of
metabolic
risk
factors
for
acute
myocardial
infarction
(AMI)
is
necessary
healthcare
policymaking.
We
estimated
future
projections
incidence
diseases
in
a
multi-ethnic
population
with
AMI.The
and
mortality
contributed
by
AMI
(diabetes
mellitus
[T2DM],
hypertension,
hyperlipidemia,
overweight/obesity,
active/previous
smokers)
were
projected
up
to
year
2050,
using
linear
Poisson
regression
models
based
on
Singapore
Myocardial
Infarction
Registry
from
2007
2018.
Forecast
analysis
was
stratified
age,
sex
ethnicity.From
2025
predicted
rise
194.4%
482
1418
per
100,000
population.
The
largest
percentage
increase
within
be
overweight/obesity
(880.0%
increase),
followed
hypertension
(248.7%
T2DM
(215.7%
hyperlipidemia
(205.0%
smoking
(164.8%
increase).
number
AMI-related
deaths
expected
294.7%
individuals
while
decrease
11.7%
29.9%
32.7%
49.6%
smokers,
2050.
Compared
Chinese
individuals,
Indian
Malay
bear
disproportionate
burden
mortality.The
continue
rising
coming
decades.
Overweight/obesity
will
emerge
as
fastest-growing
factor
leading
mortality.This
research
supported
NUHS
Seed
Fund
(NUHSRO/2022/058/RO5+6/Seed-Mar/03)
National
Medical
Research
Council
Training
Fellowship
(MOH-001131).
SMIR
national,
ministry-funded
registry
run
Diseases
Office
funded
Ministry
Health,
Singapore.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1807 - 1807
Published: Feb. 2, 2024
The
relationship
between
gut
dysbiosis
and
body
mass
index
(BMI)
in
non-diabetic
patients
with
non-alcoholic
fatty
liver
disease
(NAFLD)
is
not
adequately
characterized.
This
study
aimed
to
assess
microbiota's
signature
individuals
NAFLD
stratified
by
BMI.
16S
ribosomal
RNA
sequencing
was
performed
for
microbiota
composition
100
16
healthy
individuals.
differential
abundance
of
bacterial
groups
analyzed
using
the
DESeq2
method.
alpha
diversity
(Chao1,
Shannon,
observed
feature)
beta
significantly
differed
controls.
However,
significant
differences
their
diversities
were
among
subgroups
NAFLD.
At
phylum
level,
there
no
trend
an
elevated
