Transplantation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Background.
Alcohol-associated
liver
disease
(ALD)
is
the
leading
indication
for
transplantation
(LT)
in
Western
world.
Although
6
mo
of
abstinence
no
longer
a
criterion
patients
with
ALD,
outcomes
living
donor
LT
(LDLT)
versus
deceased
(DDLT)
are
not
well
established.
Methodss.
We
performed
an
intention-to-treat
analysis
to
evaluate
impact
listing
and
pursuing
primary
LDLT
(pLDLT)
compared
DDLT
(pDDLT).
The
endpoint
was
overall
survival
from
date
listing,
evaluated
using
Cox
regression
(hazard
ratios).
Results.
Two
hundred
thirty-three
ALD
were
listed
LT,
which
27
(12%)
pLDLT.
median
model
end-stage
(MELD)
score
at
20
Na-MELD
24,
4.5
mo,
128
(55%)
underwent
transplantation.
There
statistically
significant
adjusted
difference
3-y
between
pLDLT
pDDLT
(adjusted
hazard
ratio
[HR]
0.72;
P
=
0.550)
as-treated
(HR
1.22;
0.741).
No
delisted
group,
whereas
86
(42%)
group;
primarily
because
death
(46
[50%])
medical
improvement
(24
[28%]).
Alcohol
use
since
time
documented
29
(13%)
patients;
immortal
bias
found
HR
1.07;
0.900)
2.95;
0.130).
Conclusions.
Patients
benefit
intention
lower
rates
waitlist
dropout
delisting,
attributable
mortality
or
deterioration,
should
be
encouraged
pursue
this
option.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 9, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
common
type
of
chronic
and
its
incidence
increasing.
Its
progression
closely
related
to
non-alcoholic
steatohepatitis
fibrosis.
Effective
treatment
currently
lacking.
The
traditional
Chinese
medicine
ginseng
(Panax
ginseng)
shows
unique
advantages
in
NAFLD
intervention,
but
complex
compositional
system
molecular
mechanism
network
still
need
be
systematically
analyzed.
This
paper
integrates
evidence
from
nearly
20
years
research
elucidate
the
multi-target
pharmacological
for
NAFLD.
Relevant
information
was
sourced
Pubmed,
Web
science,
Embase
CNKI
databases.
Using
BioRender
visio
draw
biomedical
illustrations.
active
ingredients
contain
2
classes
saponins
(tetracyclic
triterpene
saponins,
pentacyclic
other
modified
types)
non-saponins.
Different
cultivation
methods,
processing
techniques
extraction
sites
have
expanded
variety
constituents
demonstrated
different
activities.
Studies
shown
that
functional
components
ability
regulate
lipid
metabolism
disorders,
inflammation,
oxidative
stress,
endoplasmic
reticulum
insulin
resistance,
disruption
intestinal
flora
structure,
cell
death
senescence.
Demonstrates
potential
study
reveals
first
time
integrative
through
tertiary
mode
action
"multi-component
multi-pathway".
multilevel
modulatory
provides
new
direction
development
comprehensive
therapeutic
strategies
Transplantation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Background.
Alcohol-associated
liver
disease
(ALD)
is
the
leading
indication
for
transplantation
(LT)
in
Western
world.
Although
6
mo
of
abstinence
no
longer
a
criterion
patients
with
ALD,
outcomes
living
donor
LT
(LDLT)
versus
deceased
(DDLT)
are
not
well
established.
Methodss.
We
performed
an
intention-to-treat
analysis
to
evaluate
impact
listing
and
pursuing
primary
LDLT
(pLDLT)
compared
DDLT
(pDDLT).
The
endpoint
was
overall
survival
from
date
listing,
evaluated
using
Cox
regression
(hazard
ratios).
Results.
Two
hundred
thirty-three
ALD
were
listed
LT,
which
27
(12%)
pLDLT.
median
model
end-stage
(MELD)
score
at
20
Na-MELD
24,
4.5
mo,
128
(55%)
underwent
transplantation.
There
statistically
significant
adjusted
difference
3-y
between
pLDLT
pDDLT
(adjusted
hazard
ratio
[HR]
0.72;
P
=
0.550)
as-treated
(HR
1.22;
0.741).
No
delisted
group,
whereas
86
(42%)
group;
primarily
because
death
(46
[50%])
medical
improvement
(24
[28%]).
Alcohol
use
since
time
documented
29
(13%)
patients;
immortal
bias
found
HR
1.07;
0.900)
2.95;
0.130).
Conclusions.
Patients
benefit
intention
lower
rates
waitlist
dropout
delisting,
attributable
mortality
or
deterioration,
should
be
encouraged
pursue
this
option.
