Liver International, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 18, 2024
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is linked to various intrahepatic extrahepatic diseases, but its association with severe infectious remains be investigated. Methods We analysed data from the Shanghai Suburban Adult Cohort Biobank, encompassing participants enrolled in 2016 2017 available abdominal ultrasonography data, followed them up until December 2022 (median follow‐up = 5.71 years). categorised into MASLD group those without (non‐SLD). Multivariable‐adjusted Cox regression was used estimate hazard ratios (HR) for infections patients compared non‐SLD group. Cumulative incidences were calculated while accounting competing risks (non‐infection‐related deaths). Mediation analyses performed explore roles of cardiometabolic risk factors between infections. Results Among 33 072 eligible (mean age 56.37 years; 38.20% male), 11 908 (36.01%) diagnosed at baseline. Severe occurred 912 (7.66%) 1258 (5.94%) non‐SLD. The rate per 1000 person‐years higher (13.58) than comparators (10.48) (fully adjusted HR 1.18, 95% CI 1.07–1.30). most frequent respiratory (7.25/1000 person‐years) urinary tract (2.61/1000 person‐years). 5‐year cumulative incidence 6.79% (95% 6.36–7.26) 5.08% 4.79–5.38) comparators. Cardiometabolic factors, including waist circumference, triglycerides HbA1C, partially mediate Conclusions Patients significantly incident Future studies are needed elucidate mechanisms linking
Language: Английский
Citations
1Effects of COVID-19 on the Liver and Mortality in Patients with SARS-CoV-2 Pneumonia Caused by Delta and Non-Delta Variants: An Analysis in a Single Centre
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 3 - 3
Published: Dec. 19, 2023
The aim of this study was to ascertain patient characteristics, outcomes, and liver injuries in patients infected with different SARS-CoV-2 variants. Data from consecutive adult severe/critical COVID-19 admitted our hospital during the peak month Delta wave were compared ancestral, Alpha, Omicron waves. dataset 551 hospitalized similar Delta/non-Delta At admission discharge, median aminotransferase levels normal or slightly increased. During (172 vs. 379 non-Delta patients), more died (OR 1.69, 95%CI 1.09–2.56) had injury at discharge (alanine aminotransferase, ALT ≥ 2 ULN) 1.97, 1.08–3.54). In-hospital mortality associated age, lung injury, intensive care unit admission, number cardiovascular comorbidities, diabetes, chronic kidney disease, all inflammatory biomarkers. Serious (ALT 5 × significantly in-hospital = 7.9, 2–28.9). drug-induced (DILI) found treated remdesivir, ULN 2.62, 1.22–5.75). Treatment dexamethasone, immunomodulators showed improved survival, OR 0.50 (95%CI 0.33–0.77). Regardless variant treatment options, less than 2% displayed serious which not be a death predictor multivariable analysis.
Language: Английский
Citations
3Erhöhtes Infektionsrisiko bei nichtalkoholischer Fettlebererkrankung (NAFLD)?
Zeitschrift für Gastroenterologie, Journal Year: 2024, Volume and Issue: 62(04), P. 449 - 450
Published: April 1, 2024
Obgleich klinische Beobachtungen einen Zusammenhang zwischen einer nichtalkoholischen Fettlebererkrankung (NAFLD) und einem erhöhten Infektionsrisiko nahelegen, mangelt es bislang an größeren Kohortenstudien mit bioptischem NAFLD-Nachweis. Ebrahimi et al. wollten daher eine Wissenslücke schließen stellen nun die Ergebnisse ihrer bevölkerungsbasierten Kohortenstudie schwedischen Erwachsenen vor.
Citations
0Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Increased Risk of Severe Bacterial Infections: A Meta-Analysis
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: July 3, 2024
Language: Английский
Citations
0PD-L1+ Neutrophils mediate Susceptibility during Systemic Inflammatory Response in Non-Alcoholic Fatty Liver Disease
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 18, 2024
Abstract Non-alcoholic fatty liver disease (NAFLD) is a pathological condition affecting individuals worldwide. Patients with NAFLD are more susceptible to systemic inflammation, such as sepsis, which accelerates damage. However, the immunological mechanisms that trigger hyper-inflammatory responses in remain unknown. In present study, we reported short-term HFCD (Choline Deficient High Fat Diet)-fed mice, did not show significative signs of hepatic damage and inflammation first two weeks, mortality after lipopolysaccharide (LPS) challenge. Mechanistically, endotoxemic mice an excessive accumulation NK-producing IFN-γ cells tissue triggering recruitment polarization distinct neutrophil subset, characterized by high PD-L1 expression massive TNFα production. Remarkably, genetic inhibition or pharmacological blockade effectively modulated these neutrophils release, thereby preventing reducing severity host mortality. Thus, results support design novel effective strategies control hyperinflammatory patients HFCDs consequently prevent mortality..
Language: Английский
Citations
0PD-L1+ Neutrophils mediate Susceptibility during Systemic Inflammatory Response in Non-Alcoholic Fatty Liver Disease
Published: Dec. 4, 2024
Non-alcoholic fatty liver disease (NAFLD) is a pathological condition affecting individuals worldwide. Patients with NAFLD are more susceptible to systemic inflammation, such as sepsis, which accelerates damage. However, the immunological mechanisms that trigger hyper-inflammatory responses in remain unknown. In present study, we reported short-term HFCD (Choline Deficient High Fat Diet)-fed mice, did not show significative signs of hepatic damage and inflammation first two weeks, mortality after lipopolysaccharide (LPS) challenge. Mechanistically, endotoxemic mice an excessive accumulation NK-producing IFN-γ cells tissue triggering recruitment polarization distinct neutrophil subset, characterized by high PD-L1 expression massive TNFα production. Remarkably, genetic inhibition or pharmacological blockade effectively modulated these neutrophils release, thereby preventing reducing severity host mortality. Thus, results support design novel effective strategies control hyperinflammatory patients HFCDs consequently prevent mortality..
Language: Английский
Citations
0PD-L1+ Neutrophils mediate Susceptibility during Systemic Inflammatory Response in Non-Alcoholic Fatty Liver Disease
Published: Dec. 4, 2024
Non-alcoholic fatty liver disease (NAFLD) is a pathological condition affecting individuals worldwide. Patients with NAFLD are more susceptible to systemic inflammation, such as sepsis, which accelerates damage. However, the immunological mechanisms that trigger hyper-inflammatory responses in remain unknown. In present study, we reported short-term HFCD (Choline Deficient High Fat Diet)-fed mice, did not show significative signs of hepatic damage and inflammation first two weeks, mortality after lipopolysaccharide (LPS) challenge. Mechanistically, endotoxemic mice an excessive accumulation NK-producing IFN-γ cells tissue triggering recruitment polarization distinct neutrophil subset, characterized by high PD-L1 expression massive TNFα production. Remarkably, genetic inhibition or pharmacological blockade effectively modulated these neutrophils release, thereby preventing reducing severity host mortality. Thus, results support design novel effective strategies control hyperinflammatory patients HFCDs consequently prevent mortality..
Language: Английский
Citations
0Response Letter: Association Between
Liver International, Journal Year: 2024, Volume and Issue: 45(1)
Published: Dec. 17, 2024
The authors have nothing to report.
Language: Английский
Citations
0MASLD as a Multisystemic Disease
Published: Jan. 1, 2024
Language: Английский
Citations
0