Anticipation in families with MLH1‐associated Lynch syndrome DOI Creative Commons
Arti Pandey, Christine Drogan, Dezheng Huo

et al.

Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background Lynch syndrome (LS) is an autosomal‐dominant, hereditary cancer predisposition caused by pathogenic variants (PVs) in one of the mismatch‐repair genes MLH1 , MSH2/EPCAM MSH6 or PMS2 . Individuals who have PVs high lifetime risks colorectal (CRC) and endometrial (EC). There controversy regarding whether a younger age at diagnosis (or anticipation) occurs ‐associated LS. The objective this study was to assess anticipation families with MLH1‐ associated LS using statistical models while controlling for potential confounders. Methods Data from 31 were obtained academic registry. Wilcoxon signed‐rank tests on parent–child‐pairs as well parametric Weibull semiparametric Cox proportional hazards mixed‐effects used calculate hazard ratios compare mean ages CRC/EC generation. Models also corrected ascertainment bias birth‐cohort effects. Results A trend toward successive generations, ranging 3.2 15.7 years, observed PV carrier families. greater generations not precluded inclusion birth cohorts model. had no Mlh1 activity 78% than those retained activity. Conclusions current results demonstrated evidence support across all models. Mutational effects influenced CRC/EC. Screening based youngest MLH1‐LS recommended.

Language: Английский

Gut archaeal biomarkers in colorectal cancer prediction: a tale of opportunity and prudence DOI
Raúl Y. Tito, Jeroen Raes

Gastroenterology, Journal Year: 2024, Volume and Issue: 168(3), P. 457 - 458

Published: Nov. 30, 2024

Language: Английский

Citations

1
Extending the Reach of Colorectal Screening to all Populations in the United States DOI Creative Commons
Seo Hyun Kim, Divya P. Prajapati, Samir Gupta

et al.

Techniques and Innovations in Gastrointestinal Endoscopy, Journal Year: 2024, Volume and Issue: 26(2), P. 153 - 166

Published: Jan. 1, 2024

In this narrative review, we provide an overview of the current reach colorectal cancer (CRC) screening in U.S. population, how persistent inequities CRC across age and sociodemographic groups changes epidemiology, as well population structure, have increased urgency achieving optimal reach, future strategies for optimizing impact population. saves lives, but including is highly variable. participation remains at under 60%, has been stagnant over time. Lower observed individuals younger age, American Indian/Alaska Native, Asian, Hispanic backgrounds, with Medicaid insurance, recent immigration. Addressing suboptimal increasingly important due to changing epidemiology structure. Recent trends demonstrate increases early (<50 years) middle (50 60 onset non-localized stage CRC, outcomes among multiple racial/ethnic groups. These exist a context where comprised from diverse backgrounds associated lower rates higher adverse outcomes. Screening can be optimized by building on successes prior impactful policies, implementing evidence-based interventions screening, developing novel that address challenges patient, clinician, healthcare system, policy levels. Gastroenterologists, other clinicians, public health advocates major role leading positive change each these Overall, need optimize represents pressing opportunity improving equity all populations

Language: Английский

Citations

0
Translation element EIF4A1 is a potential divergent immune biomarker between colon cancer and rectal cancer DOI
Zhenpeng Zhu, Peng Wang, Chenyang Hou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Colorectal cancer is among the most common malignant tumors globally, and distinct treatment requirements for colon rectal cancers underscore necessity to identify specific molecules each type. Although EIF4A1 plays a crucial role in translational initiation, its therapeutic potential remains unclear. This study utilized TCGA database reveal that expression upregulated both types associated with poorer survival outcomes. KEGG GO analyses indicate primarily extracellular trap network of neutrophils cancer. Additionally, strong positive correlation neutrophil infiltration observed cancers. Notably, exhibits varying immune patterns, showing CD8+ T cells negative CD4+ In cancer, shows PD-1, PD-L1, CTLA4, LAG-3, contrasted by weaker Elevated potentially linked checkpoints facilitate escape, thereby possibly accelerating progression. implies immunotherapy strategies

Language: Английский

Citations

0
E-cigarette Smoking and Colorectal Cancer Screening DOI
Eugene Annor, Joseph Atarere, Quarshie Glover

et al.

American Journal of Health Promotion, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Purpose To evaluate how CRC screening practices differ between e-cigarette users and non-users. Design Cross-sectional study design. Setting National Cancer Institute’s Health Information Trends Survey (HINTS 5). Subjects Respondents aged 45 to 75 years. Measures Demographics, screening, use, cancer history, presence of comorbidities, access a primary care provider. Analysis The demographic characteristics the participants were evaluated by their smoking status using chi-squared tests. differences in non-users multivariate logistic regression model. Results We identified total 6963 participants, which 181 (2.6%) users. prevalence use was inversely related age. A significant portion uninsured (10.7% vs 5.9% non-users), almost half (49.9%) current tobacco smokers. E-cigarette as likely undergo compared [OR 1.40; 95% CI (0.74, 2.66)]. Increasing age, educational level, health insurance, comorbidity, provider, personal history cancer, comorbidity associated with increased participation screening. However, not Conclusion Our found no difference rates While behaviors appear unaffected for now, ongoing surveillance is important more reach age given uncertainties surrounding long-term effects use.

Language: Английский

Citations

0
Global, regional, and national burden of early-onset colorectal cancer and projection to 2050: An analysis based on the Global Burden of Disease Study 2021 DOI
Xinyi Li,

Xueyan Xiao,

Zenghong Wu

et al.

Public Health, Journal Year: 2024, Volume and Issue: 238, P. 245 - 253

Published: Dec. 18, 2024

Language: Английский

Citations

0
In vivo and in vitro studies on the role of regulating Smac expression in the occurrence and development of colon cancer DOI Creative Commons
Donglei Zhang, Ning Yang

Cellular and Molecular Biology, Journal Year: 2024, Volume and Issue: 70(6), P. 206 - 210

Published: June 5, 2024

Language: Английский

Citations

0
Anticipation in families with MLH1‐associated Lynch syndrome DOI Creative Commons
Arti Pandey, Christine Drogan, Dezheng Huo

et al.

Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background Lynch syndrome (LS) is an autosomal‐dominant, hereditary cancer predisposition caused by pathogenic variants (PVs) in one of the mismatch‐repair genes MLH1 , MSH2/EPCAM MSH6 or PMS2 . Individuals who have PVs high lifetime risks colorectal (CRC) and endometrial (EC). There controversy regarding whether a younger age at diagnosis (or anticipation) occurs ‐associated LS. The objective this study was to assess anticipation families with MLH1‐ associated LS using statistical models while controlling for potential confounders. Methods Data from 31 were obtained academic registry. Wilcoxon signed‐rank tests on parent–child‐pairs as well parametric Weibull semiparametric Cox proportional hazards mixed‐effects used calculate hazard ratios compare mean ages CRC/EC generation. Models also corrected ascertainment bias birth‐cohort effects. Results A trend toward successive generations, ranging 3.2 15.7 years, observed PV carrier families. greater generations not precluded inclusion birth cohorts model. had no Mlh1 activity 78% than those retained activity. Conclusions current results demonstrated evidence support across all models. Mutational effects influenced CRC/EC. Screening based youngest MLH1‐LS recommended.

Language: Английский

Citations

0