A Precise Route to Tetrasubstituted Allyl Amines via Regioselective Dicarbofunctionalization of Masked Propargyl Amines DOI
Aradhana Sahoo, Shubham Dutta, Akhila K. Sahoo

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9746 - 9751

Published: Nov. 7, 2024

Allyl amines are vital components in various biologically important molecules and play a significant role their function. Presently, most methods geared toward the preparation of di- trisubstituted allyl amines, leaving gap for development more versatile approaches. We herein describe an approach to yield tetrasubstituted through palladium (Pd)-catalyzed regioselective dicarbofunctionalization masked N-phthalimide-protected propargyl amines. The cationic Pd-intermediate conjunction with amine exerts collective control reaction regioselectivity. This method accommodates wide range alkynes, aryl boronic acids, diazonium salts offering direct access unusual

Language: Английский

Site-Selective Decarbonylative [4+2] Annulation of Carboxylic Acids with Terminal Alkynes by C–C/C–H Activation Strategy and Cluster Catalysis DOI Creative Commons

Mengjie Cen,

Xinyue Ma, Xi Yang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(48), P. 20346 - 20354

Published: Jan. 1, 2024

A highly site-selective decarbonylative [4 + 2] cyclization of carboxylic acids with terminal alkynes forming naphthalenes is enabled by palladium cluster catalysis.

Language: Английский

Citations

4
Dehydrogenative α,γ-Diphosphinylation of Allylamines Enabled by Photoinduced Cobaloxime Catalysis DOI
Jun Guo, Yana Zhang, Miaomiao Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

A regioselective radical α,γ-diphosphinylation of allylamines with secondary phosphine oxides by photoinduced cobaloxime catalysis is described. The reaction tolerates a wide range and oxides, affording α-amino diphosphine dioxides in moderate to good yields hydrogen evolution. synthesis new monoxide ligands the promising antitumor activities products demonstrate great potential applications this approach drug discovery. detailed mechanism studies indicate that likely proceeds through dehydrogenative allylic phosphinylation nucleophilic addition process.

Language: Английский

Citations

1
A Precise Route to Tetrasubstituted Allyl Amines via Regioselective Dicarbofunctionalization of Masked Propargyl Amines DOI
Aradhana Sahoo, Shubham Dutta, Akhila K. Sahoo

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9746 - 9751

Published: Nov. 7, 2024

Allyl amines are vital components in various biologically important molecules and play a significant role their function. Presently, most methods geared toward the preparation of di- trisubstituted allyl amines, leaving gap for development more versatile approaches. We herein describe an approach to yield tetrasubstituted through palladium (Pd)-catalyzed regioselective dicarbofunctionalization masked N-phthalimide-protected propargyl amines. The cationic Pd-intermediate conjunction with amine exerts collective control reaction regioselectivity. This method accommodates wide range alkynes, aryl boronic acids, diazonium salts offering direct access unusual

Language: Английский

Citations

0