Nondegradative Synthetic Molecular Glues Enter the Clinic DOI Creative Commons

Maximilian L. Repity,

Robin C. E. Deutscher,

Felix Hausch

et al.

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Molecular glues are small molecules that can induce or stabilize protein–protein interactions between proteins inside cells. Unlike classical molecule drugs, molecular target challenging disease‐causing lacking well‐defined binding pockets. Nature has repeatedly used this mode of action, but identifying for new been a major challenge. Recently, manmade glues, inspired by natural products, KRas, entered clinical trials although KRas is cancer long thought to be undruggable. Here, how these initially discovered and optimized provide several advanced drug candidates various KRas‐dependent types outlined. The insights obtained class modalities further summarized. These results showcase do not rely on protein degradation benefits targets.

Language: Английский

Nondegradative Synthetic Molecular Glues Enter the Clinic DOI Creative Commons

Maximilian L. Repity,

Robin C. E. Deutscher,

Felix Hausch

et al.

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Molecular glues are small molecules that can induce or stabilize protein–protein interactions between proteins inside cells. Unlike classical molecule drugs, molecular target challenging disease‐causing lacking well‐defined binding pockets. Nature has repeatedly used this mode of action, but identifying for new been a major challenge. Recently, manmade glues, inspired by natural products, KRas, entered clinical trials although KRas is cancer long thought to be undruggable. Here, how these initially discovered and optimized provide several advanced drug candidates various KRas‐dependent types outlined. The insights obtained class modalities further summarized. These results showcase do not rely on protein degradation benefits targets.

Language: Английский

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