Environmental Sciences Europe,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Feb. 6, 2024
Abstract
Glyphosate
(GLY),
the
most
widely
used
herbicide
active
ingredient
(AI)
in
world,
is
frequently
detected
aquatic
environments
where
it
can
affect
non-target
organisms.
Globally,
more
than
2000
commercial
GLY-based
herbicides
(GBHs)
are
to
control
weeds.
Non-target
organisms
exposed
complex
pesticide
formulations
under
real
environmental
conditions,
but
co-formulants
contained
GBHs
classified
as
so-called
inert
and
inactive
ingredients
terms
of
their
biological
effects.
The
main
objective
this
comprehensive
review
compile
results
ecotoxicological
studies
on
side-effects
GLY,
GBHs,
formulating
agents.
Based
demonstrated
for
a
variety
plant
animal
organisms,
oxidative
stress
appears
be
major
trigger
these
adverse
effects,
affecting
integrity
DNA
other
biochemical
functions.
Furthermore,
there
evidence
impairment
various
physiological
behavioral
Adverse
effects
GLY
have
been
observed
even
at
very
low
concentrations.
There
also
differences
sensitivity
tested,
with
similar
lifestyles,
habitats
or
identical
taxa.
typically
investigate
short-term
single
exposure
GLY/GBH
species,
whilst
reality
multiple
applications
together
pesticides
common
during
cropping
cycle.
Moreover,
interactions
between
GLY/GBHs
contaminants
rarely
studied.
Higher
toxicity
compared
alone
has
often
observed,
demonstrating
that
highly
toxic
own
markedly
increase
GBH
formulation.
possible
impurities
such
heavy
metals,
cause
additional
problems
environment
food
safety.
widespread
massive
use
leads
increased
hazards.
In
addition,
need
revision
risk
assessment
system
emphasized.
According
studies,
current
pollution
by
problematic
cannot
considered
environmentally
sustainable.
It
is,
therefore,
necessary
least
tighten
permitted
forms
use.
Frontiers in Molecular Biosciences,
Journal Year:
2021,
Volume and Issue:
8
Published: May 17, 2021
Most
research
on
mechanisms
of
aging
is
being
conducted
in
a
very
limited
number
classical
model
species,
i.e.,
laboratory
mouse
(
Mus
musculus
),
rat
Rattus
norvegicus
domestica
the
common
fruit
fly
Drosophila
melanogaster
)
and
roundworm
Caenorhabditis
elegans
).
The
obvious
advantages
using
these
models
are
access
to
resources
such
as
strains
with
known
genetic
properties,
high-quality
genomic
transcriptomic
sequencing
data,
versatile
experimental
manipulation
capabilities
including
well-established
genome
editing
tools,
well
extensive
experience
husbandry.
However,
this
approach
may
introduce
interpretation
biases
due
specific
characteristics
investigated
which
lead
inappropriate,
or
even
false,
generalization.
For
example,
it
still
unclear
what
extent
knowledge
gained
short-lived
organisms
transferable
long-lived
species
humans.
In
addition,
other
adaptations
favoring
long
healthy
life
from
immense
evolutionary
toolbox
be
entirely
missed.
review,
we
summarize
emerging
animal
that
have
attracted
attention
gerontologists,
provide
an
overview
available
data
related
models,
important
insights
them
recent
years.
presented
include
ones
killifish
Nothobranchius
furzeri
primates
Callithrix
jacchus,
Cebus
imitator,
Macaca
mulatta
bathyergid
mole-rats
Heterocephalus
glaber,
Fukomys
spp.
bats
Myotis
birds,
olms
Proteus
anguinus
turtles,
greenland
sharks,
bivalves
(Arctica
islandica
potentially
non-aging
Hydra
Planaria
.
ACS Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
10(4), P. 1026 - 1033
Published: March 27, 2024
Parasitic
vector-borne
diseases
(VBDs)
represent
nearly
20%
of
the
global
burden
infectious
diseases.
Moreover,
spread
VBDs
is
enhanced
by
travel,
urbanization,
and
climate
change.
Treatment
faces
challenges
due
to
limitations
existing
drugs,
as
potential
for
side
effects
in
nontarget
species
raises
significant
environmental
concerns.
Consequently,
considering
risks
early
drug
development
processes
critically
important.
Here,
we
examine
risk
assessment
process
veterinary
medicinal
products
European
Union
identify
major
gaps
ecotoxicity
data
these
drugs.
By
highlighting
scarcity
ecotoxicological
commonly
used
antiparasitic
stress
urgent
need
One
Health
concept.
We
advocate
employing
predictive
tools
nonanimal
methodologies
such
New
Approach
Methodologies
at
stages
research
development.
Furthermore,
adopting
progressive
approaches
mitigate
ecological
requires
integration
nonstandard
tests
that
account
real-world
complexities
use
environmentally
relevant
exposure
scenarios.
Such
a
strategy
vital
sustainable
it
adheres
principles
Health,
ultimately
contributing
healthier
more
world.
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology,
Journal Year:
2022,
Volume and Issue:
261, P. 109446 - 109446
Published: Aug. 24, 2022
Chlorpyrifos
(CPF)
and
cypermethrin
(CYP)
are
two
insecticides
that
have
a
proven
negative
effect
on
non-target
aquatic
organisms
when
they
enter
the
surface
waters.
However,
literature
comparative
effects
of
these
pesticides
important
aquaculture
fish
species,
such
as
common
carp
(Cyprinus
carpio
Linnaeus,
1758)
is
not
yet
scientifically
detailed,
especially
over
long-term.
The
idea
conducting
long-term
exposure
to
find
out
how
observed
biomarkers
would
change
compared
short-term
exposure.
In
natural
environment,
toxicants
present
alone,
but
in
combination.
By
monitoring
impact
individual
substances,
state
ecosystems
exposed
various
could
be
predicted.
Thus,
this
study
aimed
evaluate
toxicity
different
concentrations
CYP
(0.0002,
0.0003,
0.0006
μg/L)
CPF
(0.03,
0.05,
0.10
50-L
glass
tanks
C.
carpio,
for
30
days
under
laboratory
conditions.
A
set
histological
biochemical
gills
liver
were
applied
with
chemical
analyses
water
organs.
Furthermore,
condition
hepatosomatic
index
calculated
assess
physiological
status
treated
carps.
behavioral
responses
also
monitored,
respiration
rate
was
analyzed.
results
suggest
had
more
prominent
structure
organs,
anti-oxidant
enzymes,
behavior,
CPF.
addition,
indicate
susceptible
chronic
chemically
induced
cellular
stress
gills,
overall
destructive
changes
rather
than
adaptive.
Regardless
scenario,
our
provide
novel
insights
into
pesticide
possible
biological
impacts
economically
freshwater
fish,
lower
concentrations,
based
EU
legislation
(maximum
allowable
MAC-EQS).
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
912, P. 169573 - 169573
Published: Dec. 25, 2023
At
present,
there
is
a
serious
concern
about
the
alarming
number
of
recalcitrant
contaminants
that
can
negatively
affect
biodiversity
threatening
ecological
status
marine,
estuarine,
freshwater,
and
terrestrial
ecosystems
(e.g.,
agricultural
soils
forests).
Contaminants
emerging
(CEC)
such
as
pharmaceuticals
(PHAR),
illicit
drugs
(ID),
industrial
persistent
pollutants,
polychlorinated
biphenyls
(PCBs)
polybrominated
diphenyl
ethers
(PBDEs)
chiral
ionic
solvents
are
globally
spread
potentially
toxic
to
non-target
organisms.
More
than
half
these
have
been
measured
at
different
enantiomeric
proportions
in
diverse
ecosystems.
Enantiomers
exhibit
toxicodynamics
toxicokinetics,
thus,
cause
effects.
Therefore,
distribution
occurrence
cannot
be
neglected
toxicity
other
adverse
biological
effects
expected
enantioselective.
Hence,
this
review
aims
reinforce
recognition
stereochemistry
environmental
risk
assessment
(ERA)
CEC
gather
up-to-date
information
current
knowledge
regarding
enantioselectivity
ecotoxicity
PHAR,
ID,
pollutants
(PCBs
PBDEs)
present
freshwater
soil
We
performed
an
online
literature
search
obtain
state-of-the-art
research
enantioselective
studies
available
for
assessing
impact
classes
CEC.
Ecotoxicity
assays
carried
out
using
organisms
belonging
trophic
levels
microorganisms,
plants,
invertebrates,
vertebrates,
considering
ecologically
relevant
aquatic
species
or
models
recommended
by
regulatory
entities.
A
battery
was
also
reported
encompassing
standard
acute
sub-chronic
chronic
endpoints
biomarkers
biochemical,
morphological
alterations,
reproduction,
behavior,
etc.).
Nevertheless,
we
call
attention
lack
potential
many
several
compounds.
Additionally,
questions
key
species,
selection
most
appropriate
toxicological
ERA
addressed
critically
discussed.
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 12, 2024
ABSTRACT
Behavioural
analysis
has
been
attracting
significant
attention
as
a
broad
indicator
of
sub‐lethal
toxicity
and
secured
place
an
important
subdiscipline
in
ecotoxicology.
Among
the
most
notable
characteristics
behavioural
research,
compared
to
other
established
approaches
ecotoxicology
(e.g.
reproductive
developmental
bioassays),
are
wide
range
study
designs
being
used
diversity
endpoints
considered.
At
same
time,
environmental
hazard
risk
assessment,
which
underpins
regulatory
decisions
protect
environment
from
potentially
harmful
chemicals,
often
recommends
that
ecotoxicological
data
be
produced
following
accepted
validated
test
guidelines.
These
guidelines
typically
do
not
address
changes,
meaning
these,
sensitive,
effects
represented
assessments.
Here,
we
propose
new
tool,
EthoCRED
evaluation
method,
for
assessing
relevance
reliability
ecotoxicity
data,
considers
unique
requirements
challenges
encountered
this
field.
This
method
accompanying
reporting
recommendations
designed
serve
extension
“Criteria
Reporting
Evaluating
Ecotoxicity
Data
(CRED)”
project.
As
such,
can
both
accommodate
array
experimental
design
seen
ecotoxicology,
could
readily
implemented
into
frameworks
deemed
appropriate
by
policy
makers
different
jurisdictions
allow
better
integration
knowledge
gained
testing
protection.
Furthermore,
through
our
recommendations,
aim
improve
studies
peer‐reviewed
literature,
thereby
increase
their
usefulness
inform
chemical
regulation.
