Associations between metals and metabolomic profiles related to diabetes among adults in a rural region DOI Creative Commons
Julia Debertin, Elizabeth A. Holzhausen, Douglas I. Walker

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 243, P. 117776 - 117776

Published: Dec. 2, 2023

Exposure to metals is associated with increased risk of type 2 diabetes (T2D). Potential mechanisms for metals-T2D associations involve biological processes including oxidative stress and disruption insulin-regulated glucose uptake. In this study, we assessed whether between metal exposure metabolite profiles relate pathways linked T2D. We used data from 29 adults rural Colorado residents enrolled in the San Luis Valley Diabetes Study. Urinary concentrations arsenic, cadmium, cobalt, lead, manganese, tungsten were measured. Metabolic effects evaluated using untargeted metabolic profiling, which included 61,851 signals detected serum. cross-sectional metabolites present at least 50% samples. Primary analyses adjusted urinary heavy creatinine. Metabolite outcomes each pathway enrichment investigate potential underlying relationship Participants had a mean age 58.5 years (standard deviation = 9.2), 48.3% female, identified as Hispanic/Latino, 13.8% current smokers, 65.5% Of metabolites, 455 one metal, 42 22 10 313 66 two tungsten. The features 25 linoleate metabolism, butanoate arginine proline metabolism. Several these have been previously T2D, our results similar when only participants Our support hypothesis that may be related amino acid, co-enzyme, sugar fatty acid Insight into could influence interventions prevent adverse health due exposure.

Language: Английский

Metals levels and human health risk assessment in eight commercial fish species collected from a market, Wuhan, China DOI Creative Commons
Jiaojiao Yin,

Liangyu Cheng,

Xiaoming Jiang

et al.

Frontiers in Sustainable Food Systems, Journal Year: 2024, Volume and Issue: 8

Published: April 19, 2024

Introduction Heavy metals are ubiquitous environmental pollutants, and fish could be contaminated by these metals, potentially posing a threat to human health through the food chain. Understanding accumulation of in tissues is crucial for assessing safety consuming products. Methods In this study, distribution nickel (Ni), copper (Cu), zinc (Zn), cadmium (Cd), lead (Pb) eight species ( Ctenopharyngodon idellus, Megalobrama amblycephala, Hypophthalmichthys molitrix, nobilis, Carassius auratus, Cyprinus carpio, Culter alburnus , Lateolabrax japonicas ) collected from Baishazhou market with different trophic levels habitat preference was investigated using inductively coupled plasma mass spectrometry (ICP-MS). The metal capacity assessed, pollution index (MPI) calculated evaluate extent ability each species. Additionally, risk assessment conducted potential posed Results exhibited variation among species, showing an order Zn > Cu Ni Pb Cd. terms tissues, head demonstrated greater compared muscles. Regarding varied depending on specific metal, exhibiting following according MPI: H. molitrix (0.568) C. auratus (0.508) M. amblycephala (0.469) idellus (0.336) (0.315) carpio (0.274) L. japonicus (0.263) nobilis (0.206). Furthermore, accordance results assessment, there no associated consumption as all target hazard quotient (THQ) values (ranger not detected 0.192) were below 1, maximum (HI) value observed (0.519 adults, 0.622 children). Conclusion findings study demonstrate heavy indicate bought market.

Language: Английский

Citations

3
Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study DOI Creative Commons
Dongmei Wang, Hong Ye, Siyang Liu

et al.

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: July 9, 2024

Abstract Background Although several studies have found the relationship between essential elements and diabetes, about association of with diabetes diagnosed according to an oral glucose tolerance test (OGTT) glycated hemoglobin (HbA1c) in a sex- age-specific manner were limited. To investigate linear nonlinear five including iron (Fe), copper (Cu), Zinc (Zn), magnesium (Mg), calcium (Ca) fasting plasma (FPG), 2-h postprandial (PPG), HbA1c evaluate heterogeneities these relationships. Methods A total 8392 community-dwelling adults recruited complete questionnaire undergo checkups anthropometric parameters serum levels metals (Fe, Cu, Zn, Mg, Ca). The multivariable logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis applied find associations prevalence as well FPG, PPG, HbA1c. Results In regression Cu was positively associated while Mg significantly inversely correlated HbA1c, (all P < 0.001). RCS non-linear ( 0.001) found. stronger positive for interaction = 0.027) PPG 0.002) younger women. Conclusions These findings may lead more appropriate approaches supplementation people different ages sexes. However, prospective cohort experimental are needed probe possible mechanism diabetes.

Language: Английский

Citations

3
Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China DOI
Jing Zhang, Huanhuan Yin, Xuemei Zhu

et al.

Journal of Diabetes Investigation, Journal Year: 2022, Volume and Issue: 13(8), P. 1412 - 1425

Published: March 27, 2022

Metals play an important role in diabetes mellitus. This cross-sectional study aimed to evaluate the overall, individual and interactive effects of multi-metal exposure on prevalence mellitus, impaired fasting glucose (IFG) rate blood (FBG) levels.

Language: Английский

Citations

14
Comparative plasma metabolomic analysis to identify biomarkers for lead-induced cognitive impairment DOI
Yuqin Wang,

Yuan Nong,

Xing Zhang

et al.

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 366, P. 110143 - 110143

Published: Sept. 2, 2022

Language: Английский

Citations

14
Associations between metals and metabolomic profiles related to diabetes among adults in a rural region DOI Creative Commons
Julia Debertin, Elizabeth A. Holzhausen, Douglas I. Walker

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 243, P. 117776 - 117776

Published: Dec. 2, 2023

Exposure to metals is associated with increased risk of type 2 diabetes (T2D). Potential mechanisms for metals-T2D associations involve biological processes including oxidative stress and disruption insulin-regulated glucose uptake. In this study, we assessed whether between metal exposure metabolite profiles relate pathways linked T2D. We used data from 29 adults rural Colorado residents enrolled in the San Luis Valley Diabetes Study. Urinary concentrations arsenic, cadmium, cobalt, lead, manganese, tungsten were measured. Metabolic effects evaluated using untargeted metabolic profiling, which included 61,851 signals detected serum. cross-sectional metabolites present at least 50% samples. Primary analyses adjusted urinary heavy creatinine. Metabolite outcomes each pathway enrichment investigate potential underlying relationship Participants had a mean age 58.5 years (standard deviation = 9.2), 48.3% female, identified as Hispanic/Latino, 13.8% current smokers, 65.5% Of metabolites, 455 one metal, 42 22 10 313 66 two tungsten. The features 25 linoleate metabolism, butanoate arginine proline metabolism. Several these have been previously T2D, our results similar when only participants Our support hypothesis that may be related amino acid, co-enzyme, sugar fatty acid Insight into could influence interventions prevent adverse health due exposure.

Language: Английский

Citations

7