The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods DOI Creative Commons

Jan Chrz,

Markéta Dvořáková,

Kristína Kejlová

et al.

Journal of Xenobiotics, Journal Year: 2023, Volume and Issue: 14(1), P. 15 - 30

Published: Dec. 21, 2023

Triclosan and Triclocarban, preservatives widely used in cosmetics other consumer products, underwent evaluation using a battery of new-approach methodologies vitro (NAMs). Specifically, the Microplate Ames Test (MPF™ Test, Xenometrix, Allschwil, Switzerland) was employed to assess mutagenicity, Comet assay on HaCat cell line Mammalian Chromosome Aberration were utilized evaluate genotoxicity, XenoScreen® YES/YAS applied investigate endocrine disruption. The chemicals did not exhibit any positive responses for mutagenicity. However, mammalian chromosome aberration test identified both as being genotoxicity at 10 µg/mL. In assay, percentage DNA tail significantly increased concentration-dependent manner (at 5 µg/mL Triclosan, 2.5, 5, Triclocarban). response depended increasing concentration duration exposure. but Triclocarban assays performed, indicated potential activity anti-estrogenic anti-androgenic assays. results detected obtained concentrations relevant final products. alarming findings with use (NAMs) justify current precautionary regulatory approach, limiting these preservatives.

Language: Английский

Presence of Benzotriazole Ultraviolet Stabilizers in Human Urine DOI
Weili Mao, Hangbiao Jin,

Ruyue Guo

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 260, P. 119556 - 119556

Published: July 3, 2024

Language: Английский

Citations

1
2-Mercaptobenzothiazole-derived vulcanization accelerators in urine samples from Chinese adults DOI
Xiaoyu Wu, Yingying Zhu,

Ruyue Guo

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176815 - 176815

Published: Oct. 10, 2024

Language: Английский

Citations

1
Trimester-specific exposure to triclocarban during pregnancy: Associations with oxidative stress and size at birth DOI
Hongna Zhang, Qiong Luo,

Chengchen Hu

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 907, P. 168100 - 168100

Published: Oct. 28, 2023

Language: Английский

Citations

3
Triclocarban exhibits higher adipogenic activity than triclosan through peroxisome proliferator-activated receptors pathways DOI

Jia-Da Zhang,

Sen He,

Ting-Ting He

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 342, P. 123030 - 123030

Published: Nov. 27, 2023

Language: Английский

Citations

3
The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods DOI Creative Commons

Jan Chrz,

Markéta Dvořáková,

Kristína Kejlová

et al.

Journal of Xenobiotics, Journal Year: 2023, Volume and Issue: 14(1), P. 15 - 30

Published: Dec. 21, 2023

Triclosan and Triclocarban, preservatives widely used in cosmetics other consumer products, underwent evaluation using a battery of new-approach methodologies vitro (NAMs). Specifically, the Microplate Ames Test (MPF™ Test, Xenometrix, Allschwil, Switzerland) was employed to assess mutagenicity, Comet assay on HaCat cell line Mammalian Chromosome Aberration were utilized evaluate genotoxicity, XenoScreen® YES/YAS applied investigate endocrine disruption. The chemicals did not exhibit any positive responses for mutagenicity. However, mammalian chromosome aberration test identified both as being genotoxicity at 10 µg/mL. In assay, percentage DNA tail significantly increased concentration-dependent manner (at 5 µg/mL Triclosan, 2.5, 5, Triclocarban). response depended increasing concentration duration exposure. but Triclocarban assays performed, indicated potential activity anti-estrogenic anti-androgenic assays. results detected obtained concentrations relevant final products. alarming findings with use (NAMs) justify current precautionary regulatory approach, limiting these preservatives.

Language: Английский

Citations

3