Journal of Immunotoxicology,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Feb. 14, 2023
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
used
in
a
multitude
of
processes
products,
including
nonstick
coatings,
food
wrappers,
fire-fighting
foams.
These
chemicals
environmentally-persistent,
ubiquitous,
can
be
detected
the
serum
98%
Americans.
Despite
evidence
that
PFASs
alter
adaptive
immunity,
few
studies
have
investigated
their
effects
on
innate
immunity.
The
report
here
presents
results
impact
nine
environmentally-relevant
[e.g.
perfluorooctanoic
acid
(PFOA),
perfluorooctane
sulfonic
potassium
salt
(PFOS-K),
perfluorononanoic
(PFNA),
perfluorohexanoic
(PFHxA),
perfluorohexane
(PFHxS),
perfluorobutane
(PFBS),
ammonium
perfluoro(2-methyl-3-oxahexanoate)
(GenX),
7H-perfluoro-4-methyl-3,6-dioxa-octane
(Nafion
byproduct
2),
perfluoromethoxyacetic
sodium
(PFMOAA-Na)]
one
component
immune
response,
neutrophil
respiratory
burst.
burst
is
key
process
by
which
microbicidal
reactive
oxygen
species
(ROS)
rapidly
induced
neutrophils
response
to
pathogens;
defects
increase
susceptibility
infection.
study
utilized
larval
zebrafish,
human
neutrophil-like
cell
line,
primary
ascertain
whether
PFAS
exposure
inhibits
ROS
production
It
was
observed
PFHxA
GenX
suppresses
zebrafish
larvae
line.
also
suppressed
neutrophils.
This
first
demonstrate
these
suppress
function
support
utility
employing
line
as
screening
tools
identify
may
function.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(4), P. 1842 - 1853
Published: Jan. 16, 2024
Following
its
introduction
as
an
alternative
to
perfluorooctanoic
acid,
hexafluoropropylene
oxide
dimer
acid
(HFPO-DA)
has
been
extensively
detected
in
various
environmental
matrices.
Despite
this
prevalence,
limited
information
is
available
regarding
hepatotoxicity
biomarkers.
In
study,
toxicokinetic
simulations
indicated
that
under
repeated
treatment,
HFPO-DA
mice
serum
reached
a
steady
state
by
the
4th
day.
To
assess
subacute
hepatic
effects
and
identify
potential
biomarkers,
were
administered
orally
at
doses
of
0,
0.1,
0.5,
2.5,
12.5,
or
62.5
mg/kg/d
for
7
d.
Results
revealed
lowest
observed
adverse
effect
levels
0.5
hepatomegaly
2.5
injury.
Serum
metabolomics
analysis
identified
34,
58,
118
differential
metabolites
groups,
respectively,
compared
control
group.
Based
on
weighted
gene
coexpression
network
analysis,
eight
hepatotoxicity-related
identified;
among
them,
kynurenic
(KA)
mouse
exhibited
highest
correlation
with
liver
Furthermore,
liver-targeted
demonstrated
exposure
induced
metabolic
migration
kynurenine
pathway
from
KA
nicotinamide
adenine
dinucleotide,
resulting
activation
endoplasmic
reticulum
stress
nuclear
factor
kappa-B
signaling
pathway.
Notably,
pretreatment
significantly
attenuated
injury
mice,
highlighting
pivotal
roles
HFPO-DA.
Environment International,
Journal Year:
2024,
Volume and Issue:
186, P. 108582 - 108582
Published: March 16, 2024
Perfluoroalkyl
and
polyfluoroalkyl
substances
(PFASs)
are
synthetic
chemicals,
encompassing
compounds
like
perfluorooctane
sulfonate
(PFOS),
which
have
widespread
applications
across
various
industries,
including
food
packaging
firefighting.
In
recent
years,
China
has
increasingly
employed
6:2
Cl-PFESA
as
an
alternative
to
PFOS.
Although
the
association
between
PFAS
exposure
hepatocellular
carcinoma
(HCC)
been
demonstrated,
underlying
mechanisms
that
promote
HCC
proliferation
uncleared.
Therefore,
we
aimed
investigate
effects
differences
of
PFOS
on
through
in
vivo
vitro
tumor
models.
Our
results
reveal
both
significantly
contribute
vivo.
Exposure
led
reduced
population
doubling
times,
enlarged
cell
colony
sizes,
enhanced
DNA
synthesis
efficiency,
a
higher
proportion
cells
undergoing
mitosis.
Furthermore,
Cl-PFES)
shown
activate
PI3K/AKT/mTOR
signaling
pathway
inhibit
necroptosis.
This
action
consequently
enhances
cells.
phenotypic
assay
findings
suggest
tumorigenic
potential
surpasses
PFOS;
subcutaneous
model
using
nude
mice,
mean
weight
for
Cl-PFESA-treated
cohort
was
2.33
times
observed
(p
<
0.01).
Despite
being
considered
safer
substitute
PFOS,
pronounced
this
chemical
growth
warrant
thorough
assessment
hepatotoxicity
risks
linked
its
usage.
ACS ES&T Water,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Endocrine
disrupting
compounds
(EDCs)
are
emerging
environmental
pollutants
that
cause
detrimental
effects
on
aquatic
organisms
and
humans
despite
being
present
in
the
environment
at
trace
level.
There
is
insufficient
detailed
baseline
data
ecological
risk
assessments
river
basins
globally,
their
ubiquity
freshwater
environments.
Thus,
this
study
investigated
abundance,
distribution,
risks
of
EDCs
surface
water
tropical
basin,
using
combination
solid
phase
extraction
liquid
chromatography-tandem
mass
spectrometry.
Approximately,
seven
were
detected,
encompassing
bisphenol
A
(BPA),
S,
F
(BPF),
perfluorooctanesulfonate,
perfluorooctanoic
acid,
17α-ethynylestradiol
(EE2),
17β-estradiol
(E2)
Selangor
River
Basin.
BPF
was
observed
to
be
most
prevalent
compound
1098.40
ng/L
followed
by
BPA
(358.05
ng/L).
Human
activities,
including
industrial,
commercial,
residential
waste
discharge
into
tributaries
lower
streams,
greatly
influence
prevalence
EE2
E2
had
significant
(risk
quotient
>
1)
may
possess
organisms.
This
addresses
urgent
need
for
EDC
regulatory
measures
mitigation
strategies
protect
ecosystems.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(3), P. 1259 - 1275
Published: Jan. 9, 2023
Per-
and
polyfluoroalkyl
substances
(PFASs)
have
been
mass-produced
widely
applied
in
consumer
industrial
products,
resulting
their
widespread
presence
the
environment.
Features
such
as
environmental
persistence,
bioaccumulation,
high
toxicity
even
at
low
doses
made
PFASs
an
increasing
concern.
This
brief
review
focuses
on
soil
PFASs,
especially
effect
of
other
media
potential
threats
to
human
health
through
daily
diet.
Specifically,
contamination
caused
by
different
pathways
was
first
investigated.
Soil
pollution
from
application
aqueous
film-forming
foams
(AFFFs)
is
generally
more
severe
than
that
fluorochemical
manufacturing
plants,
followed
biosolid
land
use,
landfill,
irrigation.
Factors,
carbon
chain
length
wastewater
treatment
technology,
geographical
conditions,
regional
development
level,
are
related
PFASs'
pollution.
Then,
migration,
characteristics
were
analyzed.
Short-chain
higher
solubility,
mobility,
bioavailability,
while
long-chain
bioaccumulation
toxic
organisms.
Factors
texture,
solution
chemistry
enzymes,
fertilization
conditions
also
influence
behavior
PFASs.
The
risk
exposure
agricultural
animal
products
difficult
control
varies
depending
living
region,
age,
eating
habits,
lifestyle,
ethnicity,
etc.
threaten
drinking
water
safety,
affect
function,
enter
food
webs,
threatening
health.
Knowledge
gaps
perspectives
these
research
fields
included
current
work
assist
future
effectively
investigate
understand
risks
thereby
reducing
exposure.
