Contamination of the terrestrial food chain by per- and polyfluoroalkyl substances (PFAS) and related human health risks: A systematic review

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 961, P. 178337 - 178337

Published: Jan. 1, 2025

PFAS contamination is a global issue, affecting various food sources, especially animal-based products like eggs and dairy. Collect scientific evidence of the presence in diverse edible resources along with related risks to human health, pursuing following objectives: determination level terrestrial chain contamination; health risk. Scopus, PubMed, Web Science databases. 4952 papers published from January 2013 August 2024 were retrieved at end selection process, 40 studies included. Clear description methodology used for detection; relevance or species, their parts, intended consumption; assessment Higher number China, 17, Italy 6 studies. The most detected PFOA PFOS. PFOS was maximum concentration about ng/g 2.5 ng/g, muscles cow pork, respectively. Among animal products, contaminated higher than 100 ng/g. For PFBS ranged 35 up 45 In vegetables, highest per- polyfluoroalkyl root, fruit, leaf vegetables 60 as PFBA. Daily Intake (DI) values toddlers, whereas lowest adult population. Concerning total diet, DI 30 (ng/kg bw/day) 90 bw/day). widespread PFAS, need new strategies reduce chains, emphasized. Gaps legislation limits detection methods also noted.

Language: Английский

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Determinants of maternal and neonatal PFAS concentrations: a review

Environmental Health, Journal Year: 2023, Volume and Issue: 22(1)

Published: May 10, 2023

Per- and polyfluoroalkyl substances (PFAS) are used for their properties such as stain water resistance. The have been associated with adverse health outcomes in both pregnant mothers infants, including pre-eclampsia low birthweight. A growing body of research suggests that PFAS transferred from mother to fetus through the placenta, leading utero exposure. systematic review was performed using PubMed database search studies evaluating determinants concentrations blood matrices neonates shortly after birth. Studies were included this if an observational study design utilized, exposure at least one analyte measured, measured maternal or neonatal matrices, determinant assessed, results beta estimates provided. We identified 35 inclusion evaluated relationships among factors collected these studies. Parity, breastfeeding history, race country origin, household income had strongest most consistent evidence support roles certain mothers. Reported findings on smoking status, alcohol consumption, pre-pregnancy mass index (BMI) suggest not important neonates. Further into informative consumer product use, detailed dietary information, consumed sources potential is needed. Research critical estimate past exposure, build improved models, further our understanding dose-response relationships, which can influence epidemiological risk assessment evaluations. Given exposed PFAS, it identify understand better implement public interventions populations.

Language: Английский

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Association of diet with per- and polyfluoroalkyl substances in plasma and human milk in the New Hampshire Birth Cohort Study

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 933, P. 173157 - 173157

Published: May 11, 2024

Language: Английский

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Per- and Polyfluoroalkyl Substances and Female Health Concern: Gender-based Accumulation Differences, Adverse Outcomes, and Mechanisms

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The deleterious health implications of perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely recognized. Females, in contrast to males, exhibit unique pathways for PFAS exposure excretion, leading complex outcomes. status females is largely influenced by hormone-related processes. have been reported be associated with various aspects female health, including reproductive system disorders pregnancy-related diseases. In this article, we provide insights into the correlations between female-prevalent Current epidemiological toxicological evidence has demonstrated that adverse effects on primarily attributed disruption hypothalamic-pituitary-gonadal (HPG) axis hormonal homeostasis. However, these findings do not sufficiently elucidate intricate associations specific Furthermore, autoimmune disorders, another category more prevalent women compared men, require additional investigation. Immune biomarkers pertinent observed exposure, although insufficient substantiate relations. Further thorough exploration encompassing studies essential elucidating inherent influence human pathologies. Additionally, comprehensive investigations issues beyond their functions essential.

Language: Английский

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Associations between self-reported consumption of foods and serum PFAS concentrations in a sample of pregnant women in the United States

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121461 - 121461

Published: March 1, 2025

Language: Английский

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Time trends in per- and polyfluoroalkyl substances (PFAS) concentrations in the Danish population: A review based on published and newly analyzed data

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 117036 - 117036

Published: Aug. 31, 2023

Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals used in many industries everyday consumer products exposure has been linked to several adverse health outcomes. Currently, no systematic monitoring of PFAS levels the general Danish population conducted.To study temporal trends concentrations population.In August 2023, we performed a search for original peer-reviewed reports PubMed using combinations terms Denmark. Reports were included if they comprised direct measurements serum or plasma samples. Scatter plots medians presented visualize time-trends among individuals.We 29 based on total 18,231 individuals from 19 populations. A 24 measured reports, most frequent being PFOS, PFOA, PFDA, PFNA, PFHpA, PFHpS, PFHxS. Median PFOS ranged 4.0 ng/mL 44.5 ng/mL, PFOA 0.8 9.7 while lower other PFAS. increased 1988 until late 1990s followed by decrease 2021. less clear time-trend observed PFAS.Blood have declined substantially 2021 reflecting phase-out production regulation use these Time-trends PFHxS evident, yet tendency toward decline was observed. As only some compounds measured, it is not possible determine outweighed an increase others.

Language: Английский

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Dietary exposure to per- and polyfluoroalkyl substances: Potential health impacts on human liver

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 907, P. 167945 - 167945

Published: Oct. 21, 2023

Language: Английский

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Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116897 - 116897

Published: Aug. 19, 2023

Perfluoroalkyl substances (PFAS) and phthalates are synthetic chemicals widely used in various types of consumer products. There is epidemiological experimental evidence that PFAS may alter thyroid hormone levels; however, studies children adolescents limited.To investigate the association exposure to phthalate with serum levels hormones European adolescents.A cross-sectional study was conducted 406 female 327 male (14-17 years) from Belgium, Slovakia, Spain participating Aligned Studies HBM4EU Project (FLEHS IV, PCB cohort, BEA, respectively). Concentrations perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic (PFNA), free thyroxine (FT4), triiodothyronine (FT3), thyroid-stimulating (TSH) were measured sera participants, urinary metabolites six (DEP, DiBP, DnBP, BBzP, DEHP, DiNP) non-phthalate plasticizer DINCH® quantified spot urine samples. Associations assessed linear regression g-computational models for mixtures. Effect modification by sex examined.In females, PFOA mixture concentrations associated lower FT4 higher FT3 MEP sums DiNP, (∑DEHP, ∑DiNP, ∑DINCH) FT4; ∑DEHP FT3; phthalate/DINCH® metabolite FT3. In males, TSH FT4/TSH ratio; ∑DiNP MBzP, ∑DEHP, FT4/TSH. PFOA, mono-(2-ethyl-5-hydroxyhexyl) (OH-MEHP), mono-(2-ethyl-5-oxohexyl) (oxo-MEHP), monocarboxyoctyl (MCOP) made greatest contribution effect.Results suggest sex-specific differences adolescents.

Language: Английский

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Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6887 - 6887

Published: June 23, 2024

In recent decades, emerging evidence has identified endocrine and neurologic health concerns related to exposure endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA), certain per- polyfluoroalkyl compounds (PFASs), phthalates. This resulted in consumer pressure remove these from the market, especially food-contact materials personal care products, driving their replacement with structurally or functionally similar substitutes. However, "new-generation" may be just as more harmful than predecessors some have not received adequate testing. review discusses research on early-life exposures new-generation bisphenols, PFASs, phthalates links neurodevelopmental behavioral alterations zebrafish, rodents, humans. As a whole, suggests that BPA alternatives, BPAF, newer such GenX, can significant effects neurodevelopment. The need for further research, regarding phthalate replacements bio-based is briefly discussed.

Language: Английский

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Association between exposure to perfluoroalkyl substances (PFAS) and endometriosis in the ENDEA case-control study

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175593 - 175593

Published: Aug. 23, 2024

Perfluoroalkyl substances (PFAS) are environmental contaminants present in a wide range of consumer products and frequently detected drinking water. They have been linked to adverse reproductive health outcomes women, but there is limited human evidence on the association PFAS exposure with endometriosis. To explore between plasma concentrations several PFAS, considered individually as mixture, risk endometriosis women childbearing age. Between 2018 2020, 42 patients 90 controls undergoing abdominal surgery were recruited at two public hospitals Granada, Spain. The presence or absence was ascertained by laparoscopic inspection pelvis biopsy suspected lesions (histological diagnosis). Concentrations 10 quantified samples from participants. Unconditional logistic regression employed examine associations individual summed short (∑SC) long-chain (∑LC) odds endometriosis, quantile g-computation used assess their mixture effect. In models adjusted for age, schooling, parity, perfluorotridecanoic acid (PFTrDA) associated higher (odds ratio [OR] = 1.74; 95 % CI 1.11–2.73 per 2-fold increase concentrations), while marginally significant found perfluorohexane sulfonate (PFHxS) (OR 1.45, 0.94–2.21) ∑SC 1.48; 0.96–2.30). No remaining PFAS. non-significantly 1.7-fold (95 0.73–3.80), perfluorononanoic (PFNA), PFHxS, PFTrDA being major contributors this These findings suggest that certain may However, given modest sample size, further studies warranted verify these results.

Language: Английский

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