Diacetyl
is
an
important
food
additive
with
rich
creamy
flavor
whose
excessive
intake
may
cause
various
diseases.
Herein,
for
the
first
time,
we
designed
a
dual-mode
method
diacetyl
detection
based
on
colorimetry
and
surface-enhanced
Raman
scattering
(SERS)
technology.
exhibited
excellent
oxidase-like
catalytic
activity
under
light-mediated
condition,
facilitating
oxidation
of
colorless
3,3’,5,5’-tetramethylbenzidine
(TMB)
to
blue
ox-TMB
colorimetric
detection.
Notably,
could
control
process
TMB
by
simply
adjusting
light
irradiation,
unlike
traditional
enzymatic
reactions
that
required
terminators
stop
reaction.
Interestingly,
was
ideal
marker
SERS
analysis.
Then,
three-dimensional
flower-like
zinc
oxide/silver
(ZnO/Ag)
sensitive
prepared,
which
outstanding
effect
high
enhancement
factor
1.89×108
due
effective
charge
transfer
synergistic
between
ZnO
Ag.
Based
these,
constructed
indirectly
detect
diacetyl,
has
not
been
reported
low
diacetyl.
The
linear
ranges
were
0.5-60
μM
10-9-10-5
M
respectively,
limits
0.41
0.73
nM.
Obviously,
strategy
combined
simplicity
practicality
sensitivity
SERS,
offering
great
potential
applications
in
practical
samples.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(6), P. 3338 - 3345
Published: May 30, 2024
α-Dicarbonyl
compounds
(α-DCs)
are
important
intermediate
products
during
the
thermal
processing
of
foods
and
closely
related
to
development
chronic
diseases
in
human
body.
However,
there
remains
a
significant
gap
availability
rapid
detection
methods
for
α-DCs.
So,
ratiometric
molecularly
imprinted
polymers
(RCDs@GCOFs@MIPs)
based
on
red-emitting
biomass
carbon
dots
(RCDs)
green-emitting
fluorescent
covalent
organic
frameworks
(GCOFs)
were
constructed
removal
α-DCs
food
processing.
The
sensors
exhibited
satisfactory
had
good
spiking
recoveries
milk
samples.
And
excellent
inhibition
pyrraline
(PRL)
by
was
verified
simulating
pasteurization
process.
In
addition,
onsite
achieved
recognizing
RGB
value
fluorescence
via
smartphone.
presented
new
strategy
detecting
removing
hazardous
substances
Beilstein Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
20, P. 1376 - 1395
Published: June 19, 2024
The
Cannizzaro
reaction
has
emerged
as
a
versatile
synthetic
tool
for
the
construction
of
functionalized
molecules.
Dating
back
to
19th
century,
this
reaction,
though
initially
used
synthesis
an
alcohol
and
acid
functionality
from
aldehydes,
henceforth
proven
useful
generate
diverse
molecular
entities
using
both
intermolecular
intramolecular
strategies.
Immense
applications
in
hydroxy
acids
esters,
heterocycles,
fused
carbocycles,
natural
products,
others
with
broad
substrate
scope
have
raised
profound
interest
methodological
standpoints.
ongoing
development
reagents,
solvents,
technologies
reflects
broader
trend
organic
towards
more
sustainable
efficient
practices.
focus
review
is
highlight
some
recent
advances
strategies
potentially
Nature Biotechnology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
Treatment
of
diseases
oxidative
stress
through
activation
the
antioxidant
nuclear
factor
E2-related
2
(NRF2)
is
limited
by
systemic
side
effects.
We
chemically
functionalize
NRF2
activator
monomethyl
fumarate
to
require
Baeyer–Villiger
oxidation
for
release
active
drug
at
sites
stress.
This
prodrug
reverses
chronic
pain
in
mice
with
reduced
effects
and
could
be
applied
other
disorders
Peroxides
localized
trigger
treating
mice.
Journal of Separation Science,
Journal Year:
2023,
Volume and Issue:
46(19)
Published: Aug. 7, 2023
A
reliable
method
for
determination
of
six
α-dicarbonyl
compounds
in
traditional
Chinese
medicines
was
first
developed
and
validated
by
high-performance
liquid
chromatography-fluorescence
detector
with
pre-column
derivatization.
α-Dicarbonyl
were
extracted
derivatized
2,3-diaminaphthalene.
The
derivatization
procedure
confirmed
high-resolution
mass
spectrometry.
limits
quantitation
ranged
from
3.70
×
10-3
to
2.21
10-2
μM.
established
showed
good
linearity
(regression
coefficient
>
0.9990),
precision
(relative
standard
deviation
<
3.37%),
high
recovery
(97.8%∼113.1%).
successfully
applied
detect
the
medicines.
result
exhibited
found
15
kinds
medicines,
which
suggested
us
that
should
be
paid
more
attention
quality
control
Atmospheric chemistry and physics,
Journal Year:
2023,
Volume and Issue:
23(23), P. 15135 - 15147
Published: Dec. 8, 2023
Abstract.
Organic
nitrates
(RONO2)
are
secondary
compounds
whose
fate
is
closely
related
to
the
transport
and
removal
of
NOx
in
atmosphere.
Despite
their
ubiquitous
presence
submicron
aerosols,
photochemistry
RONO2
has
only
been
investigated
gas
phase,
leaving
reactivity
condensed
phases
poorly
explored.
This
work
aims
address
this
gap
by
investigating,
for
first
time,
reaction
products
mechanisms
aqueous-phase
photolysis
four
(i.e.,
isopropyl
nitrate,
isobutyl
α-nitrooxy
acetone,
1-nitrooxy-2-propanol).
The
results
show
that
aqueous
phase
differs
significantly
from
phase.
In
contrast
where
release
upon
photolysis,
leads
primarily
direct
formation
nitrous
acid
(HONO
or
HNO2),
which
was
confirmed
quantum
chemistry
calculations.
Hence,
represents
both
a
sink
source
atmospheric
acid,
significant
precursor
⋅
OH
NO.
These
radicals
(⋅
NO)
efficiently
trapped
leading
HNO3
functionalized
RONO2.
can
thus
potentially
contribute
aging
organic
aerosol
(SOA)
serves
as
an
additional
SOA.
ACS ES&T Air,
Journal Year:
2024,
Volume and Issue:
1(8), P. 848 - 859
Published: May 21, 2024
Volatile
organic
compounds
(VOCs),
released
from
both
natural
and
anthropogenic
activities,
undergo
oxidation
in
the
atmosphere
to
form
alkyl
peroxy
radicals
(RO2)
that,
through
subsequent
chemistry,
a
variety
of
oxygenated
species
that
may
impact
air
quality
climate.
Among
potential
formed
are
nitrates
(ON)
can
be
transported
over
long
distances
contribute
ozone
production
particle
formation.
The
atmospheric
lifetime
an
ON
is
influenced
by
its
molecular
structure.
structure
impacts
further
gas
phase
reaction
(e.g.,
photolysis
photo-oxidation
with
OH
radical
reaction)
gas-to-particle
partitioning
result
multiphase
chemistry
hydrolysis)
secondary
aerosol
(SOA)
This
study
investigates
two
atmospheric-relevant
ON,
specifically,
hydroxy
nitrates,
2-methyl-1-nitrooxy-3-buten-2-ol
(C5H9NO4,
-ONO2,
C5-ON),
3-methyl-2-nitrooxy-4-penten-3-ol
(C6H11NO4,
tertiary
C6-ON).
Significant
differences
their
reactivity
demonstrated,
C5-ON
underwent
faster
photolysis,
while
C6-ON
was
more
resistant
whereas
degradation
during
OH-initiated
photo-oxidation.
These
attributed
presence
extra
methyl
group
on
C6-ON.
Furthermore,
products
demonstrate
complexity
processes
were
detected
chemical
ionization
Orbitrap
mass
spectrometry
operated
negative
mode.
Notably,
cleavage
O–N
bond
alkoxy
dominant
pathway
addition
followed
RO2
bimolecular
reactions
(i.e.,
+
or
HO2)
oxidation.
research
sheds
light
intricate
atmosphere,
emphasizing
role
fate.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(14), P. 5341 - 5341
Published: July 11, 2023
Human
exposure
to
dicarbonyls
occurs
via
ingestion
(e.g.,
food),
inhalation
electronic
cigarettes)
and
dysregulation
of
endogenous
metabolic
pathways
glycolysis).
Dicarbonyls
are
electrophiles
able
induce
carbonylation
substrate.
They
have
been
associated
with
the
onset
progression
several
human
diseases.
Several
studies
advocated
use
dicarbonyl
binders
as
food
preservatives
or
drugs
aimed
at
mitigating
carbonylation.
This
study
presents
setup
an
easy
cheap
assay
for
screening
selective
potent
binders.
The
method
is
based
on
incubation
candidate
molecules
a
molecular
probe.
activity
then
determined
by
measuring
residual
concentration
probe
over
time
liquid
chromatography
(LC).
However,
naturally
occurring
glyoxal,
methylglyoxal)
not
appealing
probes
since
they
hard
separate
detect
using
most
popular
LC
variants.
Benzylglyoxal
(BGO)
was
therefore
synthesized
tested,
proving
be
convenient
that
allows
direct
quantification
reversed
phase
without
derivatization.
qualified
assessing
binding
ability
some
known
natural
dicarbonyls,
obtaining
results
consistent
literature.
