Earth Science Informatics, Journal Year: 2024, Volume and Issue: 18(1)
Published: Dec. 22, 2024
Language: Английский
Earth Science Informatics, Journal Year: 2024, Volume and Issue: 18(1)
Published: Dec. 22, 2024
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 742 - 742
Published: March 18, 2025
Background/Objectives: Particulate matter (PM) is a primary health hazard associated with metabolic pathway disruption. Population characteristics, topography, sources, and PM components contribute to impacts. Methods: In this study, NMR-based metabolomics was used evaluate the impacts of prolonged exposure PM. Blood samples (n = 197) were collected from healthy volunteers in low- (control; CG) high-exposure areas (exposure; EG) Northern Thailand. Non-targeted metabolite analysis performed using proton nuclear magnetic resonance spectroscopy (1H-NMR). Results: Compared CG, EG showed significantly increased levels dopamine, N6-methyladenosine, 3-hydroxyproline, 5-carboxylcytosine, cytidine (p < 0.05), while biopterin, adenosine, L-Histidine, epinephrine, norepinephrine higher CG 0.05). These disturbances suggest that chronic particulate impairs energy amino acid metabolism enhancing oxidative stress, potentially contributing onset non-communicable diseases (NCDs) such as cancer neurodegenerative conditions. Conclusions: This study highlighted connection between sub-chronic PM2.5 exposure, disturbances, an risk (NCDs), stressing critical need for effective reduction strategies
Language: Английский
Citations
0Chemosphere, Journal Year: 2025, Volume and Issue: 378, P. 144390 - 144390
Published: April 8, 2025
Numerous studies linked fine particulate matter (PM2.5) to ischemic stroke. However, only a few investigated the differential associations with specific PM2.5 components and sources. We utilized electronic health records (EHR) from Mount Sinai Health System in New York City metropolitan area during 2011-2019 assessed of sources used mixed-effect Poisson survival regressions assess single-exposure chemical components. multivariable regression simultaneous source-apportioned exposures estimated using non-negative matrix factorization. Then, we sensitivity our results different specifications EHR data continuity: (1) less strict definition censorship year, (2) adjusting model for continuity index, validated algorithm measuring EHR-data based on indicators primary care service utilization. observed higher risks stroke (Risk ratio [95 % confidence intervals] per interquartile range increase) associated exposure nickel (1.080 [1.045; 1.116]), vanadium (1.070 [1.033; 1.109]), zinc (1.076 [1.031; 1.122]), nitrate (1.084 [1.039; 1.132]). In multivariate models found risk oil combustion sourced (1.061 [1.012; 1.113]). The remained consistent under accounting continuity. conclusion, an increased These findings were robust Our can inform policy interventions aimed at reducing cardiovascular disease burden.
Language: Английский
Citations
0Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121607 - 121607
Published: April 1, 2025
Language: Английский
Citations
0Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: May 6, 2025
Language: Английский
Citations
0Journal of Atmospheric Chemistry, Journal Year: 2025, Volume and Issue: 82(1)
Published: May 7, 2025
Language: Английский
Citations
0The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 982, P. 179640 - 179640
Published: May 12, 2025
Language: Английский
Citations
0The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167574 - 167574
Published: Oct. 5, 2023
Language: Английский
Citations
9Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10
Published: Oct. 11, 2023
Introduction Air pollutants are increasingly recognized to affect long-term outcomes in patients with bronchiectasis. We aimed figure out the association between air and risk of healthcare utilization Methods Data for 1,029 subjects bronchiectasis Seoul were extracted. The included particulate matter 10 μm or less diameter (PM ), 2.5 sulfur dioxide (SO 2 carbon monoxide (CO), ozone (O 3 nitrogen (NO ). outcome was all-cause uses, defined as outpatient visit, emergency department hospitalization. concentration–response curves each pollutant relative risks obtained. Results There significant correlations concentrations utilization, particularly PM , NO SO CO. This observed even at below recommended safe thresholds general population. slopes use showed a logarithmic growth pattern, steepest increase up 30 μg/m 0.030 parts per million (ppm), respectively. CO an inverted U-shaped peak 0.0045 ppm slow upward curve, No specific trends O use. Discussion Increased associated increased For bronchiectasis, there no safety those pollutants, low levels exposure can negatively impact outcomes.
Language: Английский
Citations
9Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(49), P. 20510 - 20520
Published: Dec. 1, 2023
Particulate matter (PMs) of different origins can cause diverse health effects. Here, a homemade box was used to facilitate real-time measurements breath-borne volatile organic compounds (VOCs) by gas chromatography-ion mobility spectrometry. We have tracked exhaled VOC changes in 228 Wistar rats that were injected with water-soluble PM suspension filtrates (after 0.45 μm) from 31 China cities for 1 h up 1-6 days during the experiments. Rats exposed exhibited significant VOCs within hours, featuring dynamic fluctuations levels acetone, butan-2-one, heptan-2-one-M, acetic acid-M, and ethanol. Subsequently, on fifth sixth day after injection, there notable increase proportion aldehydes (including hexanal-M, hexanal-D, pentanal, heptanal-M, (E)-2-hexenal). The 10 fingerprint patterns mentioned earlier showcased capability indirectly differentiate urban toxicity categorize into four distinct groups based their This study provides valuable insights mechanisms underscores critical role as biomarkers differentiating PMs detecting early signs potential diseases. results this work also provide scientific basis city-specific air pollution control policy development.
Language: Английский
Citations
8