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Language: Английский
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0Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142850 - 142850
Published: July 18, 2024
Language: Английский
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0Published: Aug. 9, 2024
The European Rapid Alert System for Food and Feed (RASFF) has shown 1133 notifications spices herbs in the last 10 years (2013–2023). analysis of these indicated that 58.7% (665 alerts) alerts corresponded to chemical hazards. Mycotoxins corresponding aflatoxin B1 (24 ochratoxin A (39 were found 19.4% samples. Due presence biological hazards foodstuffs, comprehensive knowledge their molecular mechanisms action is required as part risk assessment strategy. Aflatoxin (AFB1) a known potent carcinogen been linked liver cancer humans animals. Its toxic effects consist forming DNA adducts, causing mutations, interfering with cellular processes. On other hand, (OTA) be nephrotoxic, hepatotoxic, carcinogenic, immunosuppressive both OTA targets kidneys liver, exerting its similarly AFB1, i.e., through damage, oxidative stress, interference This communication reviews mechanism underlying toxicity AFB1 Europe, focusing on biosynthesis, toxicodynamics, interaction components, resulting biochemical pathways leading adverse health effects. Moreover, it discusses potential strategies mitigating spices, emphasizing importance hazard characterization effective management regulation.
Language: Английский
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