International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(16), P. 12826 - 12826
Published: Aug. 15, 2023
The
use
of
nanoparticles
like
graphene
oxide
(GO)
in
nanocomposite
industries
is
growing
very
fast.
There
a
strong
concern
that
GO
can
enter
the
environment
and
become
nanopollutatnt.
Environmental
pollutants'
exposure
usually
relates
to
low
concentrations
but
may
last
for
long
time
impact
following
generations.
Attention
should
be
paid
effects
nanoparticles,
especially
on
DNA
stability
passed
offspring.
We
investigated
multigenerational
two
strains
(wild
long-lived)
house
cricket
intoxicated
with
over
five
generations,
followed
by
one
recovery
generation.
Our
investigation
focused
oxidative
stress
parameters,
specifically
AP
sites
(apurinic/apyrimidinic
sites)
8-OHdG
(8-hydroxy-2'-deoxyguanosine),
examined
global
methylation
pattern.
Five
generations
were
able
overcome
stress,
showing
relatively
doses
have
moderate
effect
(8-OHdG
sites).
generation
experienced
transition
from
contaminated
uncontaminated
food
presented
greater
damage.
pattern
was
comparable
every
generation,
suggesting
other
epigenetic
mechanisms
might
involved.
Reproductive Biology and Endocrinology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 11, 2024
The
female
reproductive
system
can
face
serious
disorders
and
show
abnormalities
under
the
influence
of
environmental
pollutants.
Microplastics
(MPs)
nanoplastics
(NPs)
as
emerging
pollutants,
by
affecting
different
components
this
system,
may
make
fertility
a
challenge.
Animal
studies
have
demonstrated
that
exposure
to
these
substances
weakens
function
ovaries
causes
decrease
in
ovarian
reserve
capacity.
Also,
continuous
micro/nano
plastics
(MNPs)
leads
increased
levels
reactive
oxygen
species,
induction
oxidative
stress,
inflammatory
responses,
apoptosis
granulosa
cells,
reduction
number
follicles.
Furthermore,
interfering
with
hypothalamic-pituitary-ovarian
axis,
particles
disturb
normal
androgens
endocrine
balance
delay
growth
gonads.
Exposure
MNPs
accelerate
carcinogenesis
humans
animal
models.
determined
accumulate
placenta,
causing
metabolic
changes,
disrupting
development
fetus,
endangering
health
future
generations.
In
humans,
presence
micro/nanoplastics
placenta
tissue,
infant
feces,
breast
milk
has
been
reported.
These
directly
affect
mother
increasing
risk
premature
birth
other
pregnancy
complications.
This
review
aims
outline
hazardous
effects
on
fetal
discuss
results
experiments
human
research
focusing
cellular
molecular
pathways.
Recent
research
has
underscored
the
widespread
presence
of
plastic
in
diverse
ecosystems,
prompting
concerns
about
its
potential
long-term
impacts
on
organisms.
However,
reproductive
toxicity
polystyrene
nanoparticles
(PSNPs)
is
contingent
factors,
such
as
drug
concentrations,
exposure
duration,
delivery
method,
and
PSNP
characteristics.
Consequently,
evaluation
testicular
stemming
from
chronic
warrants
a
systematic
investigation.
This
study
extensively
probed
PSNPs
testes
using
multiexposure
models.
Three
distinct
paradigms
(adult,
gestational,
cross-generational
exposure)
were
executed
to
assess
PSNP-induced
(80
nm)
Drosophila.
Nevertheless,
spermatogenesis
exhibited
no
discernible
alterations
following
75,
150,
300
μg/mL
adult
gestational
Furthermore,
did
not
perturb
phenotype
or
offspring
fertility
F1
F4
generations.
These
findings
imply
that
consumption
low-dose
may
suffice
induce
dysfunction,
providing
fresh
insights
into
dosage
duration
exposure.
Insects,
Journal Year:
2025,
Volume and Issue:
16(3), P. 292 - 292
Published: March 11, 2025
Insects,
being
among
the
most
diverse
and
abundant
organisms
in
terrestrial
ecosystems,
are
inevitably
exposed
to
ubiquitous
micro-
nanoplastic
contaminants.
Although
studies
on
impact
of
these
contaminants
insects
gradually
emerging,
they
remain
limited
scope.
In
this
study,
we
investigated
biological
traits
(including
foraging
behavior,
food
assumption,
digging
ability,
body
weight
survival)
Japanese
carpenter
ant,
Camponotus
japonicus,
response
exposure
polystyrene
(PS-M/NP)
solutions
containing
three
particle
sizes
(0.05,
1
50
μm)
four
concentrations
(0.1,
1,
10
mg/mL).
The
results
showed
that
worker
ants
exhibited
significant
preference
consumption
for
non-contaminated
multiple-choice
experiments,
indicating
C.
japonicus
can
differentiate
avoid
feeding
PS-M/NP-contaminated
solutions.
Meanwhile,
PS-M/NPs
significantly
reduced
ability
no-choice
with
smallest
size
(0.05
highest
concentration
(50
mg/mL)
resulting
longest
pre-foraging
period,
lowest
percentage
licking
amount
consumption.
addition,
sand
removed
by
ants,
survival
a
dramatic
decline
decrease
size,
increase
prolonged
time
study
confirm
have
an
adverse
effect
time-dependent
manner,
small
high
longer
key
factors
decreasing
behavior
insect.
Chemical Research in Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Nanoparticles,
defined
by
their
nanoscale
dimensions
and
unique
physicochemical
properties,
are
widely
utilized
in
healthcare,
electronics,
environmental
sciences,
consumer
products.
However,
increasing
evidence
of
potential
embryotoxic
effects
during
pregnancy
underscores
the
need
for
a
molecular-level
understanding
interactions
embryonic
development.
Nanoparticles
such
as
titanium
dioxide,
silver,
cerium
oxide,
copper
quantum
dots
can
cross
placental
barrier
interfere
with
crucial
developmental
processes.
At
molecular
level,
they
disrupt
signaling
pathways
like
Wnt
Hedgehog,
induce
oxidative
stress
inflammation,
cause
genotoxic
effects,
all
critical
sensitive
phases,
organogenesis.
Furthermore,
these
nanoparticles
interact
directly
cellular
components,
including
DNA,
proteins,
lipids,
impairing
function
viability.
Innovative
strategies
to
mitigate
nanoparticle
toxicity,
surface
modifications
incorporation
biocompatible
coatings,
discussed
solutions
reduce
adverse
interactions.
Various
laboratory
animal
models
used
investigate
nanoparticle-induced
embryotoxicity
evaluated
efficacy
limitations,
providing
insights
into
applicability
effects.
This
Account
examines
mechanisms
which
compromise
development
emphasizes
importance
designing
safer
minimize
maternal-fetal
exposure
risks,
particularly
biomedical
applications.
Bulletin of Entomological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: March 28, 2025
Abstract
Influenced
by
human
activities,
microplastics
(MPs)
are
widely
distributed
in
terrestrial
ecosystems.
However,
their
ecotoxicity
remains
unclear.
Therefore,
we
assessed
the
of
polyamide
(PA-MPs)
investigating
toxic
effects
on
model
insect,
silkworms
Bombyx
mori
(Lepidoptera:
Bombycidae).
In
this
study,
fifth-instar
silkworm
larvae
were
fed
mulberry
leaves
treated
with
PA-MPs
for
120
hours,
but
no
changes
mortality
rates
observed.
body
weight,
pupal
cocoon
egg
laying
amount,
and
shell
weight
F
0
generation
significantly
reduced.
This
indicates
that
have
sublethal
silkworms.
To
further
investigate
offspring
silkworms,
applied
age-stage,
two-sex
life
table
analysis.
We
found
treatment
group,
duration
larval
stages
1
was
prolonged,
while
lifespan
adults
total
longevity
shortened.
Meanwhile,
history
parameters
(
s
xj
,
e
l
x
f
m
v
values)
population
R
λ,
r
T
)
group
also
lower
than
control.
transgenerational
effects,
affecting
growth,
development,
reproduction
Our
research
findings
demonstrate
providing
evidence
ecotoxicity.
The Science of The Total Environment,
Journal Year:
2025,
Volume and Issue:
980, P. 179545 - 179545
Published: April 30, 2025
Micro-
and
nanoplastics
(MNPLs)
are
emerging
environmental
pollutants
that
have
garnered
significant
attention
over
the
past
few
decades
due
to
their
detrimental
effects
on
human
health
through
various
exposure
pathways.
This
study
investigates
impact
of
MNPLs
gut
microbiota,
utilizing
Drosophila
melanogaster
as
a
model
organism.
was
selected
for
its
microbiota's
similarities
humans
established
role
an
accessible
well-characterized
system.
To
analyze
full-length
16S
rRNA
gene
sequencing
performed
using
Nanopore
platform,
enabling
comprehensive
profiling
microbial
populations
present
in
samples.
As
models
MNPLs,
two
commercial
polystyrene
(PS-NPLs,
61.20
415.22
nm)
one
lab-made
polylactic
acid
nanoplastic
(PLA-NPLs,
463.90
were
selected.
positive
control,
zinc
oxide
nanoparticles
(ZnO-NPs)
used.
The
observed
findings
revealed
induced
notable
alterations
including
reduction
bacterial
abundance
shifts
species
composition.
These
results
suggest
can
lead
dysbiosis
potential
disruptions
interaction,
either
with
epithelial
barrier
or
directly
resident
microorganisms.
