Biology,
Journal Year:
2024,
Volume and Issue:
13(9), P. 691 - 691
Published: Sept. 3, 2024
Mercury
(Hg)
pro-oxidant
role
on
biological
systems
and
its
biogeochemical
cycle
represent
a
serious
threat
due
to
persistence
in
marine
environment.
As
the
mitochondrial
genome
is
exposed
reactive
oxygen
species
(ROS),
aim
of
present
study
validation
variation
number
DNA
copies
(mtDNAcn)
as
biomarker
oxidative
stress
aquatic
During
summer
2021,
three
selected
fish
(Mullus
barbatus,
Diplodus
annularis
Pagellus
erythrinus)
were
collected
Augusta
Bay,
one
most
Mediterranean
contaminated
areas
remarkable
by
past
Hg
inputs,
control
area,
both
south-east
Sicily.
The
relative
mtDNAcn
was
evaluated
qPCR
specimens
each
from
sites,
characterized
respectively
higher
lower
bioaccumulation.
M.
barbatus
P.
erythrinus
showed
dramatic
reduction
compared
their
groups
while
D.
an
incredible
rising
suggesting
resilience
this
species.
These
results
align
with
dynamics
fission
fusion
triggered
environmental
toxicants.
In
conclusion,
we
suggest
implementation
valid
tool
for
early
warning
stress-related
impacts
system.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 1, 2023
Abstract
Type
2
diabetes
mellitus
(T2DM)
predominantly
considered
a
metabolic
disease
is
now
being
an
inflammatory
as
well
due
to
the
involvement
of
meta-inflammation.
Obesity-induced
adipose
tissue
inflammation
(ATI)
one
earliest
phenomena
in
case
meta-inflammation,
leading
advent
insulin
resistance
(IR)
and
T2DM.
The
key
events
ATI
are
orchestrated
by
macrophages,
which
aggravate
state
upon
activation,
ultimately
systemic
chronic
low-grade
Non-Alcoholic
Steatohepatitis
(NASH)
through
proinflammatory
cytokines.
CD44
receptor
on
macrophages
overexpressed
ATI,
NASH,
IR.
Therefore,
we
developed
targeted
Hyaluronic
Acid
functionalized
Graphene
Oxide
Quantum
Dots
(GOQD-HA)
nanocomposite
for
tissue-specific
delivery
metformin.
Metformin-loaded
GOQD-HA
(GOQD-HA-Met)
successfully
downregulated
expression
cytokines
restored
antioxidant
status
at
lower
doses
than
free
metformin
both
palmitic
acid-induced
RAW264.7
cells
diet
induced
obese
mice.
Our
study
revealed
that
nanocarrier
enhanced
efficacy
Metformin
primarily
acting
therapeutic
agent
apart
from
drug
platform.
properties
stem
HA
GOQD
having
anti-inflammatory
respectively.
This
unravels
function
option
meta-inflammation
where
itself
acts
agent.
Graphical
Chemical Research in Toxicology,
Journal Year:
2024,
Volume and Issue:
37(11), P. 1794 - 1806
Published: Nov. 1, 2024
Mitochondria,
pivotal
to
cellular
metabolism,
serve
as
the
primary
sources
of
biological
energy
and
are
key
regulators
intracellular
calcium
ion
storage,
crucial
for
maintaining
homeostasis.
Dysfunction
in
these
organelles
impairs
ATP
synthesis,
diminishing
functionality.
Emerging
evidence
implicates
mitochondrial
dysfunction
etiology
progression
diverse
diseases.
Environmental
factors
that
induce
dysregulation
raise
significant
public
health
concerns,
necessitating
a
nuanced
comprehension
classification
mitochondrial-related
hazards.
This
review
systematically
adopts
toxicological
perspective
illuminate
functions
mitochondria,
offering
comprehensive
exploration
how
toxicants
instigate
dysfunction.
It
delves
into
disruption
initiation
fragility
autophagy,
induction
mutations
DNA
by
mutagens.
The
overarching
objective
is
enhance
our
understanding
repercussions
damage
on
human
health.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(8), P. e0307166 - e0307166
Published: Aug. 12, 2024
Metformin,
the
primary
therapy
for
type
2
diabetes
mellitus
(T2DM),
showed
limitations
such
as
varying
absorption,
rapid
system
clearance,
required
large
amount,
resistance,
longstanding
side
effects.
Use
of
Nano
formulations
pharmaceuticals
is
emerging
a
viable
technique
to
reduce
negative
consequences
drug,
while
simultaneously
attaining
precise
release
and
targeted
distribution.
This
study
developed
Polyethylene
Glycol
conjugated
Graphene
Oxide
Quantum
dots
(GOQD-PEG)
nanocomposite
sustained
metformin.
Herein,
we
evaluated
effectiveness
metformin-loaded
nanoconjugate
in
vitro
insulin
resistance
model.
Results
demonstrated
drug
loaded
successfully
restored
glucose
uptake
reversed
conditions
at
reduced
dosage
compared
free
