Universal occurrence of organophosphate tri-esters and di-esters in marine sediments: Evidence from the Okinawa Trough in the East China Sea

Environmental Research, Journal Year: 2024, Volume and Issue: 248, P. 118308 - 118308

Published: Jan. 26, 2024

Language: Английский

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Exposure to resorcinol bis (diphenyl phosphate) induces colonization of alien microorganisms with potential impacts on the gut microbiota and metabolic disruption in male zebrafish

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172892 - 172892

Published: May 7, 2024

Language: Английский

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Neurodevelopmental toxicity and molecular mechanism of environmental concentration of tetrabromobisphenol A bis (2- hydroxyethyl) ether exposure to sexually developing male SD rats

Chemosphere, Journal Year: 2024, Volume and Issue: 353, P. 141378 - 141378

Published: March 3, 2024

Language: Английский

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Aggravating Pollution of Emerging Aryl Organophosphate Esters in Urban Estuarine Sediments of South China

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Emerging aryl organophosphate esters (aryl-OPEs) have been employed as substitutes for organohalogen flame retardants in recent years; however, their environmental occurrence and associated impacts urban estuarine sediments not adequately investigated, impeding regulatory decision-making. Herein, field-based investigations modeling based on surface sediment core analysis were to uncover the historical pollution current of aryl-OPEs Pearl River Estuary, South China. Our results revealed a substantial increase aryl-OPE emission, particularly emerging aryl-OPEs, through transport estuary since 2000s. The comprised 83% total annual input past decade, with an average 155,000 g. Additionally, emerging-to-traditional concentration ratios increased decreasing distance from shore, peaking highly urbanized riverine outlets. These findings indicate that inventories are likely increasing emissions surpassing those traditional aryl-OPEs. risk-based priority screening approach indicates some bisphenol A bis(diphenyl phosphate), can pose higher risk than sediments. Overall, our study highlights importance recognizing

Language: Английский

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The hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120777 - 120777

Published: Jan. 6, 2025

Language: Английский

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Synergistic neurotoxicity of clothianidin and photoaged microplastics in zebrafish: implications for neuroendocrine disruption

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125797 - 125797

Published: Feb. 1, 2025

Language: Английский

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Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity

Environmental Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Glyphosate has been widely used in agricultural production as a highly effective, low-toxic, broad-spectrum organophosphorus herbicide. However, there controversy about whether it is toxic to the nervous system. In order explore this issue depth, present study analyzed molecular mechanism of action glyphosate from four perspectives, namely, gene regulation, protein expression, morphological changes, and behavioral assessed potential effects on development system zebrafish through establishment model. The results showed that embryos at 6 hpf after fertilization were exposed until 72 120 hpf. After exposure, was found central development-related Elavl3 down-regulated, GAP-43, Neurog1, GFAP up-regulated. expression HuC protein, which maintain neuronal axonal homeostasis, significantly reduced, repair neurological damage inflammation, increased. Under regulation related genes proteins, larvae show abnormal changes during series systems such heart rate slowing, somite shortening, spinal brain malformations. At same time, zebrafish's behavior also changed, with significant decrease its total time share low-speed shift high-speed states, delayed response dark-light environmental stimuli. summary, studies have shown exposure may induce inflammation system, resulting developmental malformations, motor behavior, neurotoxicity. Therefore, possible neurotoxicity risks aquatic animals should not be ignored great concern.

Language: Английский

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Temperature- and chemical-induced neurotoxicity in zebrafish

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 3, 2023

Throughout their lives, humans encounter a plethora of substances capable inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning nervous system, some agents have been linked neurodegenerative pathologies such as Parkinson's Alzheimer's disease. The growing concern surrounding impacts both naturally occurring man-made toxic necessitates identification animal models for rapid testing across wide spectrum concentrations, utilization tools detecting system alterations spanning from molecular level up behavioural one. Zebrafish (Danio rerio) is gaining prominence in field neuroscience due its versatility. possibility analysing all developmental stages (embryo, larva adult), applying most common "omics" approaches (transcriptomics, proteomics, lipidomics, etc.) conducting range tests makes zebrafish an excellent model neurotoxicity studies. This review delves into main experimental adopted markers analysed studies zebrafish, showing that phenomena can be triggered not only by chemical but also fluctuations temperature. findings presented here serve valuable resource study define new scenarios ecotoxicology suggesting temperature synergistically compound effects substances, intensifying detrimental impact on fish populations.

Language: Английский

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Exposure of male adult zebrafish (Danio rerio) to triphenyl phosphate (TPhP) induces eye development disorders and disrupts neurotransmitter system-mediated abnormal locomotor behavior in larval offspring

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133332 - 133332

Published: Dec. 22, 2023

Language: Английский

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Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae

Chemosphere, Journal Year: 2024, Volume and Issue: 356, P. 141901 - 141901

Published: April 5, 2024

Language: Английский

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