The antidepressant, sertraline, impacts growth and reproduction in the benthic deposit feeder, Tubifex tubifex DOI Creative Commons

Wing Sze Chan,

Martina Santobuono, Elettra D'Amico

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117134 - 117134

Published: Oct. 1, 2024

Among emerging contaminants, pharmaceuticals are considered one of the most pertinent substances that may threaten aquatic ecosystems. Pharmaceuticals designed to be directed at specific metabolic- and molecular pathways. Thus, they assumed still biologically active when entering ecosystem result in unpremeditated impacts on non-target organisms. One widely used selective serotonin reuptake inhibitors, sertraline (an antidepressant), is regularly found environments. However, knowledge about effects, particular, sediment-associated benthic invertebrates limited. We examined chronic exposure (28 d) (3.3, 33, 330 μg/g dw sed.) survival, growth reproduction deposit-feeding oligochaete, Tubifex tubifex. Sertraline significantly decreased T. tubifex survival growth. Worms exposed high concentrations (330 μg/g) had a lower rate reproduction, as indicated by number cumulated cocoons. an environmentally relevant concentration (3.3 but maintained similar control. The implications adult worms presumably required more energy for maintenance detoxification, thereby reducing available This represents trade-off between In contrast, allocated slightly increasing cocoons produced quantity quality offspring impacted we observed fewer juveniles treatment than Overall, results indicate bioavailable negatively growth, even concentrations.

Language: Английский

Sub-chronic exposure to paroxetine disrupts ecologically relevant behaviours in fish DOI Creative Commons

Carla Ferreira,

Cátia Venâncio, Mónica Almeida

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170405 - 170405

Published: Jan. 26, 2024

The functional conservation of important selective serotonin reuptake inhibitor (SSRI) targets in non-target organisms raises concerns about their potential adverse effects on the ecosystems. Although environmental levels SSRIs like paroxetine (PAR) have risen, knowledge regarding long-term exposure to PAR is limited. This study investigated impact sub-chronic (21 days) two sub-lethal concentrations (40 and 400 μg/L) behaviour adult zebrafish different scenarios: basal activity (under dark light conditions), stress response (evoked by sudden transitions) recovery. A new framework was employed for integrative fish's swimming performance based innate ability respond shifts. Several swimming-associated parameters (e.g., total distance, time inactivity, angles) thigmotaxis were monitored an integrated analysis each scenario. Data revealed reduced activity, impaired behavioural alterations recovery PAR-exposed fish. An anxiolytic effect particularly noticeable fish at μg/L (from light) dark) exposed 40 μg/L. detected PAR-induced modifications suggest a disruption brain glucocorticoid signalling that may implications individual level changing responses predators), with repercussions population community levels. Therefore, applied protocol proved sensitive detecting changes induced PAR.

Language: Английский

Citations

6
Assessment of the effects of paroxetine and zinc on crustaceans through integrated quantitative and taxon/functional tools with a focus on free-living marine copepods and amphipods DOI
Mohamed Allouche,

Amal Lassoued,

Sahar Ishak

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 215, P. 117887 - 117887

Published: March 30, 2025

Language: Английский

Citations

0
Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio) DOI

Michael Tea,

Yihang K. Pan,

Joshua G. R. Lister

et al.

Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: 210(5), P. 785 - 799

Published: Feb. 28, 2024

Language: Английский

Citations

3
Sex-specific effects of psychoactive pollution on behavioral individuality and plasticity in fish DOI Creative Commons
Giovanni Polverino, Upama Aich, Jack A. Brand

et al.

Behavioral Ecology, Journal Year: 2023, Volume and Issue: 34(6), P. 969 - 978

Published: Aug. 14, 2023

Abstract The global rise of pharmaceutical contaminants in the aquatic environment poses a serious threat to ecological and evolutionary processes. Studies have traditionally focused on collateral (average) effects psychoactive pollutants ecologically relevant behaviors wildlife, often neglecting among within individuals, whether they differ between males females. We tested sex-specific behavioral individuality plasticity guppies (Poecilia reticulata), freshwater species that inhabits contaminated waterways wild. Fish were exposed fluoxetine (Prozac) for 2 years across multiple generations before their activity stress-related behavior repeatedly assayed. Using Bayesian statistical approach partitions we found males—but not females—in fluoxetine-exposed populations differed less from each other (lower individuality) than unexposed males. In sharp contrast, observed females—but males—whereby exposure even low levels resulted substantial decrease (activity) increase (freezing behavior) Our evidence reveals pollution has individual fish, suggesting females might be equally vulnerable pollutants.

Language: Английский

Citations

9
Exploring the Impact of Naphthalene (Polycyclic Aromatic Hydrocarbons) on Anabas testudineus (Bloch) through Dose-Specific Bioenzymological Analysis DOI Creative Commons
Sukhendu Dey

ACS Omega, Journal Year: 2024, Volume and Issue: 9(13), P. 14923 - 14931

Published: March 20, 2024

This study addresses the increasing concern about naphthalene, a polycyclic aromatic hydrocarbon (PAH), highlighting its growing threats to environment and aquatic life. The research examines impact on Anabas testudineus (Bloch) through detailed dose-specific bioenzymological analysis. Experimental fish groups were exposed T1 (0.71 mg/L) T2 (1.42 naphthalene concentrations, representing 25 50% of LC50 value, respectively, over 1–21 day period. Following experiment, water samples underwent physicochemical analysis, while tissues examined for diverse parameters. Among these parameters, aspirate aminotransferase (AST) alanine (ALT) serve as crucial indicators monitoring physiological status addressing pollution induced by PAHs, especially naphthalene. Statistical significance was observed in morpho-pathological changes erythrocyte alterations, particularly presence tear-drop appearance (Tr) positively interacting with swelled cells (Sc), vacuolated (Va), sickle (Sk) (P < 0.05). These findings highlight significant biomarker response exposure. A. tissue bioenzymology, apoptosis, erythrocytic alterations exposure dose-dependent. highlights overseeing controlling PAH concentrations ecosystems ensure well-being (Bloch).

Language: Английский

Citations

2
Effects of long-term fluoxetine exposure on morphology, but not behaviour or metabolic rate, in male guppies (Poecilia reticulata) DOI Creative Commons
Kate N. Fergusson,

James L. Tanner,

Jack A. Brand

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 107082 - 107082

Published: Sept. 1, 2024

Language: Английский

Citations

1
Are early and young life stages of fish affected by paroxetine? A case study with Danio rerio DOI Creative Commons

Carla Ferreira,

Cátia Venâncio, Peter Kille

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 900, P. 165706 - 165706

Published: July 25, 2023

Paroxetine (PAR) is a selective serotonin reuptake inhibitor (SSRI) antidepressant increasingly detected in surface waters worldwide. Its environmental presence raises concerns about the potential detrimental effects on non-target organisms. Thus, this study aimed to increase knowledge PAR's impacts, assessing of commercial formulation (PAR-c) and active ingredient (PAR-a) fish. Therefore, short-term exposure PAR-c PAR-a were assessed zebrafish (Danio rerio) embryos/larvae determine most toxic [through median lethal (LC50) effective concentrations (EC50)]. induced morphological abnormalities (scoliosis) dose-dependent manner from 96 hours post-fertilization onwards, suggesting involvement fully functional biotransformation system. As exhibited higher toxicity, it was selected be tested subsequent stage (juvenile stage), which more sensitive (lower LC50). significantly decreased fish swimming activity disrupted stress response. Overall, results highlight ability adversely affect performance, an effect that persisted even after ceases (21-day depuration), may impair individual fitness.

Language: Английский

Citations

3
Using the fish plasma model to evaluate potential effects of pharmaceuticals in effluent from a large urban wastewater treatment plant DOI
James P. Meador, Suzanne C. Ball, C. Andrew James

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123842 - 123842

Published: March 28, 2024

Language: Английский

Citations

0
Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish DOI Creative Commons
Daniela Correia, Marina Bellot, Júlia Goyenechea

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 355, P. 141851 - 141851

Published: April 3, 2024

Fish have common neurotransmitter pathways with humans, exhibiting a significant degree of conservation and homology. Thus, exposure to fluoxetine makes fish potentially susceptible biochemical physiological changes, similarly what is observed in humans. Over the years, several studies demonstrated potential effects on different species at levels biological organization. However, parental unexposed offspring remain largely unknown. The consequences 15-day relevant concentrations (100 1000 ng/L) were assessed using zebrafish as model organism. Parental resulted early hatching, non-inflation swimming bladder, increased malformation frequency, decreased heart rate blood flow, reduced growth. Additionally, behavioral impairment was also found (reduced startle response, basal locomotor activity, altered non-associative learning during stages negative geotaxis scototaxis, thigmotaxis, anti-social behavior later life stages). These alterations are consistent anxiety, increase expression monoaminergic genes slc6a4a (sert), slc6a3 (dat), slc18a2 (vmat2), mao, tph1a, th2, neurotransmitters. Alterations behavior, genes, persisted until adulthood. Given high neuronal between data show possibility transgenerational multigenerational pharmaceuticals' exposure. results reinforce need for fish, under realistic scenarios, provide insights into impact these pharmaceuticals.

Language: Английский

Citations

0
The Antidepressant, Sertraline, Impacts Growth and Reproduction in the Benthic Deposit Feeder, Tubifex Tubifex DOI

Wing Sze Chan,

Martina Santobuono, Elettra D'Amico

et al.

Published: Jan. 1, 2024

Among emerging contaminants, pharmaceuticals are considered one of the most pertinent substances that may threaten aquatic ecosystems. Pharmaceuticals designed to be directed at specific metabolic- and molecular pathways. Thus, they assumed still biologically active when entering ecosystem result in unpremeditated impacts on non-target organisms. One widely used selective serotonin reuptake inhibitors, sertraline (an antidepressant), is regularly found environments. However, knowledge about effects, particular, sediment-associated benthic invertebrates limited. We examined chronic exposure (28d) (3.3, 33, 330 μg/g dw sed.) survival, growth reproduction deposit-feeding oligochaete, Tubifex tubifex. Sertraline significantly decreased T. tubifex survival growth. Worms exposed high concentrations (330 μg/g) had a lower rate reproduction, as indicated by number cumulated cocoons. an environmentally relevant concentration (3.3 ug/g) but maintained similar control. The implications adult worms presumably required more energy for maintenance detoxification, reducing available This represents trade-off between In contrast, allocated slightly increasing cocoons produced quantity quality offspring impacted fewer juveniles were treatment than Overall, results indicate bioavailable negatively growth, reproduction.

Language: Английский

Citations

0