Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 11, 2024
Largemouth bass is an economically important farmed freshwater fish species that has delicious meat, no intermuscular thorns, and rapid growth rates. However, the molecular regulatory mechanisms underlying different developmental stages of this have not been reported.
Language: Английский
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116023 - 116023
Published: Jan. 30, 2024
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) toxicology based on bibliometrics. Totally 56,816 publications about from 2002 to 2023 were found Web Science Core Collection, with Toxicology as top 6 among all disciplines. Accordingly, bibliometric map reveals that "toxicity" has become a hot keyword. It further most common exposure types include acute, chronic, and combined exposure. The toxicological effects behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, reproductive transgenerational toxicity. mechanisms oxidative stress, inflammation, autophagy, dysbiosis gut microbiota. toxicants commonly evaluated by using nanomaterials, arsenic, metals, bisphenol, dioxin. Overall, provide unique well-accepted investigate mechanisms. We also discussed possible ways address some limitations model, such combination human organoids avoid species differences.
Language: Английский
Citations
34
Environmental Pollution, Journal Year: 2024, Volume and Issue: 349, P. 123997 - 123997
Published: April 16, 2024
Language: Английский
Citations
4
Published: Jan. 1, 2025
Artificial sweeteners, which serve as vital alternatives to sucrose, have been detected in agricultural soil and crops. There still knowledge gaps concerning the bioaccumulation of ASs plants, are crucial for assessing risks ecosystems. The absorption, translocation biotransformation saccharin (SAC) acesulfame (ACE) were investigated by a hydroponic experiment. Inhibition experiments indicated that uptake roots is an active, energy-requiring process, facilitated both aquaporins anion channels. Due hydrophilic nature, SAC ACE prone translocate above-ground tissues via transpiration stream. hydrophilicity also directs their primary storage water-soluble cellular components, facilitating acropetal translocation. nontarget analysis utilizing high-resolution mass spectrometry identified 12 metabolites potential degradation pathways proposed. Apart from phase I metabolites, we II underwent methylation, glutathione, glucuronide conjugation, marking firstly detection plants. ecotoxicity has predicted hydroxylated methylated demonstrated higher toxicity. To our knowledge, this study pioneers investigation mechanisms underlying accumulation offering deeper insights into behavior within plant systems.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 22, 2025
The consumption of nutritive and non-nutritive sweeteners (NNS) has increased significantly in recent decades. nutritional status pregnant women plays a crucial role determining the likelihood their offspring developing hypertension adulthood. While NNSs provide sweet taste without adding to sugar intake, emerging evidence suggests that maternal not only (such as fructose) but also NNS may lead adverse outcomes offspring, including hypertension. This review provides an overview latest research connecting intake long-term risk offspring. We examine proposed mechanisms underlying programming by sweeteners, encompassing oxidative stress, dysregulated nutrient sensing signals, abnormal renin-angiotensin system, transcriptome changes, dysbiotic gut microbiota. Additionally, we outline preventive strategies can help alleviate programmed diets high sweeteners. Recent advancements understanding through which contributes offer promise for addressing this widespread health concern at its developmental roots. Nonetheless, further is needed educate public about safety sweetener during pregnancy lactation.
Language: Английский
Citations
0
AMB Express, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 18, 2025
Natural sweeteners have attracted widespread attention because they are eco-friendly, healthy, low in calories, and tasty. The demand for natural is increasing together with the popularity of green, low-carbon, sustainable development. With development synthetic biology, microbial cell factories emerged as an effective method to produce large amounts sweeteners. This technology has significantly progressed recent years. review summarizes pathways enzymes related biosynthesis sweeteners, such mogrosides, steviol glycosides, glycyrrhizin, glycyrrhetinic acid, phlorizin, trilobatin, erythritol, sorbitol, mannitol, thaumatin, monellin, brazzein. Moreover, it focuses on research about production these using biology methods, aiming provide a reference future
Language: Английский
Citations
0
EFSA Journal, Journal Year: 2025, Volume and Issue: 23(4)
Published: April 1, 2025
The present opinion deals with the re-evaluation of acesulfame K (E 950) as a food additive. Acesulfame is chemically manufactured compound 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide potassium salt. It authorised for use in European Union (EU) accordance Regulation (EC) No 1333/2008. assessment involved comprehensive review existing authorisations, evaluations and new scientific data. was found to be stable under various conditions; at pH lower than 3 increasing temperatures, it degraded certain amount. Based on available data, no safety concerns arise genotoxicity its degradation products. For potential impurities, based silico concern identified 5-chloro-acesulfame; maximum limit 0.1 mg/kg, or alternatively, request appropriate data recommended. synthesis systematically appraised evidence human animal studies, Panel concluded that there are studies suitable identification reference point (RP) adverse effects. Consequently, established an acceptable daily intake (ADI) 15 mg/kg body weight (bw) per day highest dose tested without effects chronic toxicity carcinogenicity study rats; considered moderate risk bias one two key from previous by Scientific Committee Food (SCF) Joint FAO/WHO Expert Additives (JECFA). This revised ADI replaces 9 bw SCF. noted estimate exposure generally below all population groups. recommended Commission consider revision EU specifications 950).
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 929, P. 172757 - 172757
Published: April 24, 2024
Language: Английский
Citations
3
Chemosphere, Journal Year: 2024, Volume and Issue: 359, P. 142246 - 142246
Published: May 4, 2024
The knowledge and assessment of mixtures chemical pollutants in the aquatic environment is a complex issue that often challenging to address. In this review, we focused on use zebrafish (Danio rerio), vertebrate widely used biomedical research, as model for detecting effects with focus behaviour. Our aim was summarize current status ecotoxicological research sector. Specifically, limited our period between January 2012 September 2023, including only those works aimed at neurotoxicity through behavioural endpoints, utilizing one or more developmental stages, from egg adult. Additionally, gathered findings every group chemicals involved summarized data all included. At end screening process 101 papers were considered eligible inclusion. Results show growing interest life stages kind last decade. Also, wide variety different assays, involving senses, surveyed, exposures ranging acute chronic. conclusion, results study versatility detection mixture toxicity although, what concerns analysis, lack standardisation methods endpoints might still be limiting.
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 6, 2024
Abstract The artificial sweetener acesulfame is a persistent pollutant in wastewater worldwide. So far, only few bacterial isolates were recently found to degrade efficiently. In Bosea and Chelatococcus strains, Mn 2+ -dependent metallo-β-lactamase-type sulfatase an amidase signature family enzyme catalyze hydrolysis via acetoacetamide-N-sulfonate (ANSA) acetoacetate. Here, we describe new Shinella strains isolated from German treatment plants. Their genomes do not encode the sulfatase. Instead, formylglycine-dependent gene was found, together with ANSA on plasmid shared by all known acesulfame-degrading strains. Heterologous expression, shotgun proteomics size exclusion chromatography corroborated physiological function of as -independent Since both / novel are absent other or metagenome assembled genomes, surveyed 60 tera base pairs wastewater-associated raw datasets. regularly 2014 on, particularly North America, Europe East Asia, whereas first detected 2020. complete pathway present five datasets China, Finland Mexico, suggesting that it emerged quite facilities. Synopsis A identified hydrolyzes once recalcitrant xenobiotic acesulfame. Surveying revealed recent emergence homologs encoding this systems
Language: Английский
Citations
1
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(42), P. 18892 - 18902
Published: Oct. 7, 2024
The artificial sweetener acesulfame is a persistent pollutant in wastewater worldwide. So far, only few bacterial isolates were recently found to degrade efficiently. In
Language: Английский
Citations
1