The Body, the Brain, the Environment, and Parkinson’s Disease

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(3), P. 363 - 381

Published: April 9, 2024

The brain- and body-first models of Lewy body disorders predict that aggregated alpha-synuclein pathology usually begins in either the olfactory system or enteric nervous system. In both scenarios seems to arise structures are closely connected outside world. Environmental toxicants, including certain pesticides, industrial chemicals, air pollution therefore plausible trigger mechanisms for Parkinson’s disease dementia with bodies. Here, we propose toxicants inhaled through nose can lead pathological changes subsequently spread give rise a brain-first subtype disease. Similarly, ingested pass gut cause then extends via parasympathetic sympathetic pathways ultimately produce subtype. resulting be tracked by development symptoms, clinical assessments, vivo imaging, examination. integration environmental exposures into generates testable hypotheses, on prevalence conditions, their future incidence, imaging patterns, signatures. proposed link, though, has limitations leaves many questions unanswered, such as role skin, influence microbiome, effects ongoing exposures. Despite these limitations, interaction exogenous factors may explain mysteries open door toward ultimate goal –prevention.

Language: Английский

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Ubiquitous global use of persistent PFAS threatens Arctic Indigenous peoples for decades to come

Cell Reports Sustainability, Journal Year: 2025, Volume and Issue: unknown, P. 100341 - 100341

Published: March 1, 2025

Language: Английский

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First comprehensive assessment of dietary chlorinated paraffins intake and exposure risk for the rural population of the Tibetan Plateau, China

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 928, P. 172435 - 172435

Published: April 16, 2024

Language: Английский

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Clinical, histological, molecular, and toxicokinetic renal outcomes of per-/polyfluoroalkyl substances (PFAS) exposure: Systematic review and meta-analysis

Chemosphere, Journal Year: 2024, Volume and Issue: 368, P. 143745 - 143745

Published: Nov. 1, 2024

Language: Английский

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Perfluoroalkyl Substances in the Circumpolar Arctic and Northern Populations

Advances in Clinical Toxicology, Journal Year: 2023, Volume and Issue: 8(4), P. 1 - 13

Published: Jan. 1, 2023

Persistent organic pollutants including perfluoroalkyl substances (PFAS) are globally ubiquitous contaminants transported with sea currents and atmospheric movements, accumulating in the environment, food-chain, animals humans possess a potential health risk immune-, neurobehavioral-, reproductive systems. The profile concentrations found elicit regional differences that might be related to countries PFAS use, production, lifestyle, diet. In Arctic, compounds were never produced or used, however, Arctic Indigenous northern populations consuming traditional diet marine mammals at top of food-chain (e.g., whales, seals, polar bears) particularly exposed PFAS. This mini review gives short overview on effects circumpolar aims compare levels primary focus period 2010-20 relate general national country populations. As expected, concentration over highest level Greenland. Moreover, regulated (perfluorooctane sulfonate, perfluoro-octanoate, perfluorohexane sulfonate) tend decrease unregulated perfluorononanoic acid, perfluorodecanoic perfluoroundecanoic acid) increases during this period. Generally, higher men than women increasing age. For most regions, compared

Language: Английский

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Metal exposure in the Greenlandic ACCEPT cohort: follow-up and comparison with other Arctic populations

International Journal of Circumpolar Health, Journal Year: 2024, Volume and Issue: 83(1)

Published: July 30, 2024

Humans are exposed to metals through diet and lifestyle e.g. smoking. Some essential for physiologically body functions, while others non-essential can be toxic humans. This study follows up on metal concentrations in the Greenlandic ACCEPT birth-cohort (mothers fathers) compares with other Arctic populations. The data from 2019 2020 include blood concentrations, food frequency questionnaires 101 mothers 76 fathers, 24–55 years, living Nuuk, Sisimiut, Ilulissat. A high percentage (25–45%) exceeded international guidance values Hg. For mothers, changed significantly inclusion at pregnancy this follow-up 3–5 years after birth; some increased decreased. Most differed between few also residential towns. Several correlated marine intake socio-economic factors, but direction of correlations varied. Traditional was associated positively Se, As To best our knowledge, provides most recent exposure both men women Greenland, elucidating sources among populations, documents need continuing biomonitoring follow exceeding

Language: Английский

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Persistent organic pollutants among seafood processing workers in West Greenland

International Journal of Hygiene and Environmental Health, Journal Year: 2024, Volume and Issue: 263, P. 114484 - 114484

Published: Nov. 7, 2024

Language: Английский

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