Livestock,
Journal Year:
2024,
Volume and Issue:
29(4), P. 148 - 154
Published: July 2, 2024
Gastrointestinal
nematodes
are
among
the
most
prevalent
and
damaging
infections
faced
by
ruminant
livestock.
Anthelmintic
resistance
means
that
sustainable
control
is
essential
selective
breeding
has
been
part
of
this
for
decades.
Breeding,
however,
focused
on
promoting
to
infection,
yet
almost
no
empirical
work
done
other
which
hosts
mitigate
impact
parasites,
namely
tolerance
infection.
This
review
defines
concepts
resilience,
tolerance,
with
particular
attention
gastrointestinal
nematode
sheep.
How
selection
thus
far
implemented
discussed,
pros
cons
each
trait
evaluated.
Tolerance
completely
neglected
in
livestock
science,
its
potential
mechanisms
regard
sheep
discussed.
The
authors'
understand
more
about
role
future
also
disscussed.
The Science of The Total Environment,
Journal Year:
2025,
Volume and Issue:
968, P. 178786 - 178786
Published: Feb. 17, 2025
In
animal
husbandry,
the
macrocyclic
lactone
anthelmintic
moxidectin
is
commonly
used
and
may
accumulate
in
pasture
soils,
potentially
impacting
plant
growth
fitness.
To
investigate
these
effects
while
considering
competition,
we
conducted
a
completely
randomised
pot
experiment.
We
grew
four
temperate
grassland
species
-
Achillea
ptarmica,
Agrostis
capillaris,
Dianthus
deltoides,
Plantago
lanceolata
separately
pots,
with
soil
treated
formulated
at
three
concentration
levels
(0.1,
1,
5
μg
g-1)
or
left
untreated
(control).
half
of
added
dominant
grass
Poa
pratensis
as
competitor.
Over
full
period
greenhouse,
measured
morphological
traits:
above-ground
biomass
(APB),
specific
leaf
area
(SLA),
intact
(ILA).
Moxidectin
concentrations
parts
were
analysed
using
HPLC.
Results
showed
that
was
absorbed
by
roots
transported
to
parts.
At
highest
(5
g-1),
APB
ILA
reduced
14.4
%
19.8
%,
respectively,
compared
controls,
SLA
increased
12.2
%.
Anthelmintic
varied
competition;
for
APB,
significant
noted
only
absence
competition
out
species.
The
increases
reductions
g-1
occurred
without
one
species,
respectively.
These
findings
suggest
contamination
residues
can
negatively
affect
fitness
plants,
particularly
low-competition
areas,
such
open
patches,
which
serve
protective
microsites
recruitment.
International Journal for Parasitology Drugs and Drug Resistance,
Journal Year:
2025,
Volume and Issue:
27, P. 100579 - 100579
Published: Jan. 7, 2025
In
all
organisms,
the
biotransformation
of
xenobiotics
to
less
toxic
and
more
hydrophilic
compounds
represents
an
effective
defense
strategy.
pathogens,
drugs
(used
for
their
elimination
from
host)
may
provide
undesirable
protective
effects
that
could
potentially
compromise
drug's
efficacy.
Accordingly,
increased
drug
deactivation
via
accelerated
is
now
considered
as
one
mechanisms
resistance.
The
present
study
summarizes
current
knowledge
regarding
anthelmintics,
specifically
used
treat
mainly
nematodes,
a
group
parasites
are
significant
health
concern
humans
animals.
main
enzymes
introduced
roles
in
anthelmintics
metabolism
nematodes
discussed
with
particular
focus
on
potential
participation
Similarly,
inducibility
sublethal
doses
presented
view
its
contribution
resistance
development.
conclusion,
tasks
awaiting
scientists
this
area
outlined.
Livestock,
Journal Year:
2025,
Volume and Issue:
30(Sup2a), P. S18 - S23
Published: March 1, 2025
Gastrointestinal
nematodes
are
among
the
most
prevalent
and
damaging
infections
faced
by
ruminant
livestock.
Anthelmintic
resistance
means
that
sustainable
control
is
essential
selective
breeding
has
been
part
of
this
for
decades.
Breeding,
however,
focused
on
promoting
to
infection,
yet
almost
no
empirical
work
done
other
which
hosts
mitigate
impact
parasites,
namely
tolerance
infection.
This
review
defines
concepts
resilience,
tolerance,
with
particular
attention
gastrointestinal
nematode
sheep.
How
selection
thus
far
implemented
discussed,
pros
cons
each
trait
evaluated.
Tolerance
completely
neglected
in
livestock
science,
its
potential
mechanisms
regard
sheep
discussed.
The
authors'
understand
more
about
role
future
also
disscussed.
International Journal for Parasitology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Gastro-intestinal
nematode
infections
are
considered
one
of
the
major
endemic
diseases
sheep
on
grounds
animal
health
and
economic
burden,
both
in
British
Isles
globally.
Parasites
increasingly
developing
resistance
to
commonly
used
anthelmintic
treatments
meaning
that
alternative
control
strategies
reduce
or
replace
use
anthelmintics
required.
We
present
GI-NemaTracker,
a
systems-level
mathematical
model
full
host-parasite-environment
system
governing
gastro-intestinal
transmission
farm.
The
is
based
series
time-varying
delay-differential
equations
explicitly
capture
environmentally-driven
time
delays
development.
By
taking
farm
approach
we
represent
in-host
free-living
parasite
dynamics
their
interaction
with
population
individually
modelled
lambs
diverse
trait
parameters
assigned
at
birth.
Thus
seasonally
varying
rates
consequently
variable
weight
gain
individual
throughout
season.
parameterised
for
Teladorsagia
circumcincta,
although
framework
described
could
be
applied
range
species.
validate
against
experimental
field
data
apply
it
study
efficacy
four
different
treatment
regimes
(neo-suppresive
treatment,
strategic
prophylactic
faecal
egg
counts
regime
which
leaves
10%
animals
untreated)
lamb
pasture
contamination.
predicts
similar
body
weights
flock
level
can
achieved
while
reducing
number
administered,
thus
supporting
plan
reduces
treatments.
As
capable
combining
parasitic
stages
host
performance,
well
suited
predict
complex
responses
under
non-stationary
conditions.
implications
its
potential
as
tool
development
sustainable
discussed.
New Zealand Journal of Zoology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 11
Published: Feb. 4, 2024
Dung
beetles
perform
vital
ecosystem
functions,
but
their
survival
is
threatened
by
parasiticide
use
in
veterinary
practices.
Currently,
it's
unclear
if
parasiticides
directly
harm
dung
or
cause
damage
via
secondary
effects
on
crucial
microbiome
components.
We
investigated
the
impact
of
three
commercial
(P1–levamisole
and
oxfendazole;
P2–abamectin,
levamisole
P3–moxidectin)
Onthophagus
binodis
beetle
gut
exoskeleton
microbiomes.
were
subjected
to
mixed
with
fresh
for
14
days,
we
used
16S
rRNA
genes
detect
bacterial
diversity
changes.
The
tested
didn't
alter
communities,
slightly
affected
microbiota
composition.
No
mortality
difference
was
observed.
microbiomes
are
mainly
diet-influenced,
more
adaptable
than
gut.
Our
study
suggests
that
adjustable
aren't
susceptible
due
innate
resilience.
