Livestock,
Journal Year:
2024,
Volume and Issue:
29(4), P. 148 - 154
Published: July 2, 2024
Gastrointestinal
nematodes
are
among
the
most
prevalent
and
damaging
infections
faced
by
ruminant
livestock.
Anthelmintic
resistance
means
that
sustainable
control
is
essential
selective
breeding
has
been
part
of
this
for
decades.
Breeding,
however,
focused
on
promoting
to
infection,
yet
almost
no
empirical
work
done
other
which
hosts
mitigate
impact
parasites,
namely
tolerance
infection.
This
review
defines
concepts
resilience,
tolerance,
with
particular
attention
gastrointestinal
nematode
sheep.
How
selection
thus
far
implemented
discussed,
pros
cons
each
trait
evaluated.
Tolerance
completely
neglected
in
livestock
science,
its
potential
mechanisms
regard
sheep
discussed.
The
authors'
understand
more
about
role
future
also
disscussed.
Journal of Natural Products,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 24, 2024
A
chemical
investigation
of
the
Australian
pasture
soil-derived
Actinomadura
sp.
S4S-00245B09,
supported
by
chemical,
bioactivity
and
cultivation
profiling,
yielded
a
new
class
terpenyl-quinolin-4(1H)-ones,
goondolinones
B
(1
2),
featuring
an
unprecedented
fused
seven-membered
ether.
Structures
were
assigned
to
1
2
on
basis
detailed
spectroscopic
analysis,
including
X-ray
analysis
1,
biosynthetic
considerations.
Goondolinone
(1)
lacks
antibacterial
or
antifungal
properties,
is
noncytotoxic
two
human
carcinoma
cell
lines,
but
exhibits
selective
inhibition
motility
heartworm
Dirofilaria
immitis
microfilaria
(EC50
5.1
μM)
L4
larvae
21.4
μM).
As
anthelmintic
scaffold,
future
understanding
structure
activity
relationship
mechanism
action
could
inform
discovery
treatments
for
other
filarial
diseases,
capable
safeguarding
health
welfare
companion
animals.
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(7), P. 604 - 604
Published: July 22, 2024
This
study
assessed
the
immunoprotective
effect
in
lambs
of
a
native
excreted/secreted
15-kDa
protein
and
two
synthesised
S28
peptides
derived
from
infective
transitory
larvae
(xL3)
adult
stages
(AS)
Haemonchus
contortus.
Twenty-two
Pelibuey
were
divided
into
negative
positive
control
groups,
as
well
immunised
lamb
with
100
µg
(15kDaNP)
(S28P).
The
eggs
per
gram
(EPG)
haematocrit
measured,
AS
counted
morphologically
measured.
To
assess
immunoprotection
lambs,
indirect
enzyme-linked
immunosorbent
assays
relative
expression
analyses
immune
cytokines
performed
using
serum
abomasal
samples.
Our
results
showed
72.28%
reduction
worms
(AW)
15kDaNP-immunised
group,
achieving
high
clinical
response
41%
low
EPG
values
(436
±
661).
Conversely,
S28P
group
achieved
highest
IgG
levels
(2.125
0.880
OD),
AW
exhibiting
greatest
body
length
(p
>
0.05)
upregulation
IL5
FCεR1A
genes
associated
nematode
control.
15kDaNP
increased
related
to
anti-inflammatory
responses,
including
IL4,
IL5,
IL6,
IL13
<
0.05).
should
be
explored
potential
vaccines
against
sheep
haemonchosis.
Livestock,
Journal Year:
2024,
Volume and Issue:
29(4), P. 148 - 154
Published: July 2, 2024
Gastrointestinal
nematodes
are
among
the
most
prevalent
and
damaging
infections
faced
by
ruminant
livestock.
Anthelmintic
resistance
means
that
sustainable
control
is
essential
selective
breeding
has
been
part
of
this
for
decades.
Breeding,
however,
focused
on
promoting
to
infection,
yet
almost
no
empirical
work
done
other
which
hosts
mitigate
impact
parasites,
namely
tolerance
infection.
This
review
defines
concepts
resilience,
tolerance,
with
particular
attention
gastrointestinal
nematode
sheep.
How
selection
thus
far
implemented
discussed,
pros
cons
each
trait
evaluated.
Tolerance
completely
neglected
in
livestock
science,
its
potential
mechanisms
regard
sheep
discussed.
The
authors'
understand
more
about
role
future
also
disscussed.
