The herbicide 2,4-dichlorophenoxyacetic acid induces pancreatic β-cell death via oxidative stress-activated AMPKα signal downstream-regulated apoptotic pathway
Ken-An Lin,
No information about this author
Chin‐Chuan Su,
No information about this author
Kuan-I Lee
No information about this author
et al.
Toxicology Letters,
Journal Year:
2025,
Volume and Issue:
405, P. 16 - 29
Published: Feb. 6, 2025
Language: Английский
Unraveling the pesticide-diabetes connection: A case-cohort study integrating Mendelian randomization analysis with a focus on physical activity's mitigating effect
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
283, P. 116778 - 116778
Published: July 27, 2024
There
is
no
evidence
on
the
longitudinal
and
causal
associations
between
multiple
pesticides
incidence
of
type
2
diabetes
mellitus
(T2DM)
in
Chinese
rural
population,
whether
physical
activity
(PA)
modified
these
remains
unclear.
Here,
we
aimed
to
investigate
mixture
T2DM,
determine
PA
associations.
Language: Английский
Diabetes mellitus and serum organochlorine pesticides mixtures in Mexican women
Environmental Health,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: June 13, 2024
Abstract
Background
Very
recently,
it
has
been
reported
that
exposure
to
different
mixtures
of
organochlorine
pesticides
(OCP)
is
associated
with
the
development
diabetes
mellitus
(DM).
In
Mexico,
DM
a
public
health
problem
might
be
related
historical
intense
use
OCP.
We
aimed
evaluate,
association
between
and
serum
concentrations
OCP
mixtures,
identify
main
contributors
within
them.
Methods
conducted
secondary
cross-sectional
analysis
on
control
group
from
breast
cancer
population-based
case-control
study
2007
2011
in
Northern
Mexico.
identified
214
self-reported
diabetic
women
694
non-diabetics.
obtained
direct
information
about
sociodemographic,
lifestyle
reproductive
characteristics.
determined
24
metabolites
by
gas
chromatography
using
an
electron
capture
micro
detector.
used
Weighted
Quantile
Sum
regression
assess
multiple
OCP,
contribution
each
compound
mixture.
Results
found
positive
adjusted
mixture
(OR:
2.63,
95%CI:
1.85,
3.74),
whose
primary
arose
p,
p’-DDE
(mean
weight
23.3%),
HCB
17.3%),
trans
nonachlor
15.4%),
o,
7.3%),
heptachlor
epoxide
5.9%),
oxychlordane
4.7%),
4.5%).
addition,
these
along
p’-DDT
cis
chlordane,
were
concern
remained
when
excluding
hypertensive
(OR
2.55;
95%
CI
1.56,
4.18).
Conclusions
Our
results
indicate,
for
first
time
Latin-American
population,
concomitant
DM.
Further
research
needed
since
composition
may
vary
according
regional
patterns.
Language: Английский
Unraveling the Pesticide-Diabetes Connection: A Case-Cohort Study Integrating Mendelian Randomization Analysis with a Focus on Physical Activity's Mitigating Effect
Published: Jan. 1, 2024
Language: Английский
DNA methylation in the association between pesticide exposures and type 2 diabetes
Gaoyan Zheng,
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Zhengmei Fang,
No information about this author
Baoyong Zhou
No information about this author
et al.
World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
16(2)
Published: Dec. 30, 2024
Numerous
epidemiological
studies
have
found
that
pesticide
exposure
is
associated
with
the
incidence
of
type
2
diabetes
(T2D);
however,
underlying
mechanisms
remain
unknown.
DNA
methylation
may
play
a
role
in
this
process.
To
identify
genes
and
T2D
by
reviewing
current
literature.
We
systematically
searched
PubMed
Embase
for
relevant
examined
association
between
methylation,
on
through
January
15,
2024.
identified
six
(Alu,
CABLES1,
CDH1,
PDX1,
PTEN,
PTPRN2)
related
to
T2D.
also
suggested
future
research
directions
better
define
specific
vital
Language: Английский