Endocrine-Disrupting Effects of Salicylate Preservatives on Neurosteroidogenesis: Targeting 5α-Reductase Type 1 DOI
Wanyu Li,

Rong Cui,

Shi Qi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(44), P. 24797 - 24807

Published: Oct. 25, 2024

Salicylate preservatives are widely used in consumer products and pharmaceuticals. This study investigates their potential endocrine-disrupting effects on neurosteroidogenesis, focusing 5α-reductase type 1 (SRD5A1). We evaluated the of 13 salicylates human SRD5A1 using SF126 glioblastoma cell microsomes rat brain microsomes, examining dihydrotestosterone production cells. Results revealed a hierarchy inhibitory potency against SRD5A1, with methyl salicylate (IC

Language: Английский

Impacts of food additives on gut microbiota and host health DOI
Ping Li, Ru Qu, Ming Li

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 196, P. 114998 - 114998

Published: Sept. 13, 2024

Language: Английский

Citations

5
Tea tree oil inhibits hydrogen sulfide-induced oxidative damage in chicken lungs through CYP450s/ROS pathway DOI Creative Commons

Yilei Liang,

Jiang Li,

Mao Liang Hu

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(7), P. 103860 - 103860

Published: May 15, 2024

A large amount of hydrogen sulfide (H

Language: Английский

Citations

4
Size- and Duration-Dependent Toxicity of Heavy Vehicle Tire Wear Particles in Zebrafish DOI
Qianqian Song,

Qingxuan Meng,

Xinrui Meng

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138299 - 138299

Published: April 1, 2025

Language: Английский

Citations

0
Accumulation of Parabens, Their Metabolites, and Halogenated Byproducts in Migratory Birds of Prey: A Comparative Study in Texas and North Carolina, USA DOI Creative Commons
Macarena Rojo, Ashley L. Ball,

Mike T. Penrose

et al.

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(11), P. 2365 - 2376

Published: Aug. 22, 2024

Parabens are alkyl esters of p-hydroxybenzoic acid that commonly used as preservatives in personal care products such cosmetics. Recent studies have revealed the presence parabens surface and tap water because their use disinfection products; however, little is known about occurrence biological samples bioaccumulation potential, particularly raptor birds sentinels for pollutant detection. We examined tissue distribution parabens, metabolites, halogenated byproducts liver, kidney, brain, muscle prey from Texas North Carolina (USA). Methylparaben (MeP), propylparaben (PrP), butylparaben (BuP) were detected more than 50% all tissues examined, with kidney exhibiting highest concentration MeP (0.65-6.84 ng/g wet wt). Para-hydroxybenzoic (PHBA), a primary metabolite, had detection frequency (>50%) high accumulation range 4.64 to 12.55 ng/g. The chlorinated compounds chloromethylparaben chloroethylparaben found over half tissues, which dichloromethylparaben (2.20-3.99 ng/g) dichloroethylparaben (1.01-5.95 exhibited concentrations. dibrominated derivatives dibromideethylparaben (Br2EtP) was samples, brain. Concentrations 0.14 17.38 Br2EtP kidney. Dibromidepropylparaben (Br2PrP) not frequently detected, but concentrations ranged 0.09 21.70 muscle. accumulations total amounts (sum) parent (∑P), metabolites (∑M), (∑H) different species significantly different, differed among species. Positive correlations observed MeP, PrP, BuP, PHBA suggesting similar origins metabolic pathways. Environ Toxicol Chem 2024;43:2365-2376. © 2024 Author(s). Environmental Toxicology Chemistry published by Wiley Periodicals LLC on behalf SETAC.

Language: Английский

Citations

3
Endocrine-Disrupting Effects of Salicylate Preservatives on Neurosteroidogenesis: Targeting 5α-Reductase Type 1 DOI
Wanyu Li,

Rong Cui,

Shi Qi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(44), P. 24797 - 24807

Published: Oct. 25, 2024

Salicylate preservatives are widely used in consumer products and pharmaceuticals. This study investigates their potential endocrine-disrupting effects on neurosteroidogenesis, focusing 5α-reductase type 1 (SRD5A1). We evaluated the of 13 salicylates human SRD5A1 using SF126 glioblastoma cell microsomes rat brain microsomes, examining dihydrotestosterone production cells. Results revealed a hierarchy inhibitory potency against SRD5A1, with methyl salicylate (IC

Language: Английский

Citations

0