Tracing microplastics in environmental sources and migratory shorebirds along the Central Asian Flyway

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 212, P. 117571 - 117571

Published: Jan. 27, 2025

Language: Английский

Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: 21(2), P. 387 - 397

Published: Feb. 27, 2025

Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because primary organ for xenobiotic metabolism, impact of environmental stressors on homeostasis and MASLD has garnered significant interest over past few decades. The concept metabolism-disrupting chemicals (MDCs) been introduced to underscore importance factors homeostasis. Recent epidemiological biological studies suggest causal link between exposure MDCs prevalence progression MASLD. This review aims introduce emerging their representative toxic mechanisms. In particular, this focuses broadening understanding impacts or steatohepatitis (MASH) progression. research highlighted contaminants, such as heavy metals, microplastics, pesticides, have potential influence hepatic metabolism aggravate MASLD/MASH These not only directly affect lipid hepatocytes but also other cell types, immune cells stellate cells, well gut-liver axis. Collectively, these findings contribute establishing well-defined adverse outcome pathway identify novel therapeutic options diseases associated with pollutants.

Language: Английский

Microplastics in the Eastern Arabian Sea: Decision support tools for monitoring and environmental risk reduction

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 372, P. 123160 - 123160

Published: Nov. 24, 2024

Language: Английский